NME1:2 hexamer phosphorylates 6TGDP to 6TGTP

Stable Identifier
R-HSA-9748999
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
6TGDP--NME1:2-->6TGTP
ReviewStatus
5/5
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6-thioguanine nucleotides (6-TGNs) consist of 6-thio(deoxy)guanosine 5'-monophosphate (T(d)GMP), -diphosphate (T(d)GDP), and -triphosphate (T(d)GTP), representing the pharmacologically-active metabolites involved in drug action of thiopurines.

Nucleoside diphosphate kinase (NME) plays a major role in the synthesis of nucleoside triphosphates other than ATP. NME1 forms a hexameric complex with NME2 and this complex is thought to phosphorylate 6-thioguanosine diphosphate (6TGDP) to 6-thioguanosine triphosphate (6TGTP) (Karner et al. 2010).
Literature References
PubMed ID Title Journal Year
20216118 Determination of 6-thioguanosine diphosphate and triphosphate and nucleoside diphosphate kinase activity in erythrocytes: novel targets for thiopurine therapy?

Hofmann, U, Karner, S, Schwab, M, Schaeffeler, E, Fischer, C, Herrlinger, KR, Shi, S, Neurath, MF

Ther Drug Monit 2010
Participants
Participates
Event Information
Catalyst Activity

nucleoside diphosphate kinase activity of NME1:NME2 hexamer [cytosol]

Orthologous Events
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