TP53 binds the IKBIP gene promoter

Stable Identifier
R-HSA-9749464
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TP53 binds the IKBIP gene promoter
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Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP, also known as IKIP) is located on the chromosome 12, within 0.5 kbp upstream of the apoptotic protease-activating factor 1 (APAF1) (Hofer-Warbinek R et al. 2004). IKBIP and APAF1 share a common promoter which coordinates expression of two genes in opposite directions. Expression of APAF1 was shown to be regulated by transcription factor TP53 (p53) which binds to the p53 response element in the promoter of the APAF1 gene (Robles AI et al. 2001; Fortin A et al. 2001). Like APAF1, expression of IKBIP is also regulated by TP53 (Hofer-Warbinek R et al. 2004).

This Reactome event shows binding of TP53 to the p53 response element in the promoter region of the IKBIP/APAF1 genes.

Literature References
PubMed ID Title Journal Year
15389287 A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53

Winsauer, G, Orel, L, Schmid, JA, Binder, BR, de Martin, R, Hofer-Warbinek, R, Wiesner, Ch, Mayer, H, Mueller, B

Cell Death Differ 2004
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Authored
Shamovsky, V  (2021-11-12)
Reviewed
de Martin, R  (2022-05-04)
D'Eustachio, P  (2022-01-05)
Created
Shamovsky, V  (2021-08-04)
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