Reactome | CHUK:IKBKB:LRRC14 [cytosol]

CHUK:IKBKB:LRRC14 [cytosol]

Stable Identifier

R-HSA-9749467

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Synonyms

IKBKA:IKBKB:LRRC14

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-1 signaling (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
27426725	LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex Cui, J, Ou, J, Wu, C, Yang, Y, Zhao, W, Zhu, L	Exp Cell Res	2016

Participants

components

Participates

as an output of

LRRC14 binds IKBKB and CHUK (Homo sapiens)

Inferred To

CHUK:IKBKB:LRRC14 [cytosol] (Bos taurus)

CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)

CHUK:IKBKB:LRRC14 [cytosol] (Danio rerio)

CHUK:IKBKB:LRRC14 [cytosol] (Mus musculus)

CHUK:IKBKB:LRRC14 [cytosol] (Rattus norvegicus)

CHUK:IKBKB:LRRC14 [cytosol] (Sus scrofa)

CHUK:IKBKB:LRRC14 [cytosol] (Xenopus tropicalis)