LRRC14 binds IKBKB and CHUK

Stable Identifier
R-HSA-9749505
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
LRRC14 binds IKBKB and IKBKA
ReviewStatus
5/5
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LRRC14 binds IKBKB and CHUK
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Leucine-rich repeat-containing protein 14 (LRRC14) binds to the helix-loop-helix (HLH) domain of IKBKB (Wu C et al. 2016). This binding blocks IKBKB interaction with IKBKG (NEMO) disrupting IκB kinase (IKK) complex formation and NF-kappa-B activation (Wu C et al. 2016).

Literature References
PubMed ID Title Journal Year
27426725 LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex

Cui, J, Ou, J, Wu, C, Yang, Y, Zhao, W, Zhu, L

Exp Cell Res 2016
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
negative regulation of I-kappaB kinase/NF-kappaB signaling (0043124)
Orthologous Events
LRRC14 binds IKBKB and CHUK (Bos taurus)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Danio rerio)
LRRC14 binds IKBKB and CHUK (Mus musculus)
LRRC14 binds IKBKB and CHUK (Rattus norvegicus)
LRRC14 binds IKBKB and CHUK (Sus scrofa)
LRRC14 binds IKBKB and CHUK (Xenopus tropicalis)
Authored
Shamovsky, V  (2021-11-12)
Reviewed
de Martin, R  (2022-05-04)
D'Eustachio, P  (2022-01-05)
Created
Shamovsky, V  (2021-08-04)
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