Reactome | TRIM28 [nucleoplasm]

TRIM28 [nucleoplasm]

Stable Identifier

R-HSA-974998

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription intermediary factor 1-beta, TIF1B_HUMAN, KAP1

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13263 TRIM28

Gene Names

TRIM28, KAP1, RNF96, TIF1B

Chain

initiator methionine:, chain:2-835

Reference Genes

BioGPS Gene:10155 TRIM28

COSMIC (genes):TRIM28 TRIM28

CTD Gene:10155 TRIM28

dbSNP Gene:10155 TRIM28

ENSEMBL:ENSG00000130726 TRIM28

HGNC:16384 TRIM28

KEGG:hsa:10155 TRIM28

Monarch:10155 TRIM28

NCBI Gene:10155 TRIM28

OMIM:601742 TRIM28

UCSC:Q13263 TRIM28

Reference Transcript

RefSeq:NM_005762.3 TRIM28

Other Identifiers

10155

11715373_a_at

16866337

200990_PM_at

200990_at

33425_at

3844240

3844241

3844242

3844243

3844244

3844245

3844246

3844247

3844248

3844249

3844250

3844251

3844252

3844253

3844254

3844255

3844256

3844257

3844258

3844259

3844260

3844261

3844262

3844263

3844264

3844265

3844266

3844267

3844268

3844269

3844270

3844271

3844272

3844273

3844274

3844275

8031913

A_14_P116219

A_14_P200560

A_23_P89884

GE61192

GO:0000122

GO:0000785

GO:0000791

GO:0000792

GO:0001701

GO:0001837

GO:0002376

GO:0003677

GO:0003682

GO:0003713

GO:0003714

GO:0003723

GO:0003824

GO:0004672

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0006281

GO:0006325

GO:0006346

GO:0006355

GO:0007566

GO:0008270

GO:0016740

GO:0016925

GO:0019789

GO:0022414

GO:0030154

GO:0030163

GO:0031625

GO:0032991

GO:0035851

GO:0042307

GO:0043045

GO:0043161

GO:0043226

GO:0044790

GO:0045087

GO:0045739

GO:0045869

GO:0045892

GO:0045893

GO:0048856

GO:0060028

GO:0060090

GO:0060669

GO:0061630

GO:0070087

GO:0071514

GO:0090575

GO:0098542

GO:0140096

GO:0140110

GO:1990841

HMNXSV003008569

HMNXSV003011931

ILMN_1736575

PH_hs_0025287

TC19000971.hg

U95040_at

g5032178_3p_at

g5032178_3p_x_at

Participates

as a component of

as a member of

KAP (KRAB-Domain Associated Protein) [nucleoplasm] (Homo sapiens)

This entity regulates

Negatively

Latent Transcriptinally Repressed HCMV Genome (Homo sapiens)

Other forms of this molecule

SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm]

SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm]

Inferred To

bon [nucleoplasm] (Drosophila melanogaster)

TRIM28 [nucleoplasm] (Bos taurus)

TRIM28 [nucleoplasm] (Dictyostelium discoideum)

TRIM28 [nucleoplasm] (Gallus gallus)

TRIM28 [nucleoplasm] (Sus scrofa)

Trim28 [nucleoplasm] (Mus musculus)

Trim28 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_005753.1

Guide to Pharmacology - Targets

2253

OpenTargets

ENSG00000130726

ENSEMBL

ENST00000341753, ENST00000253024, ENSG00000130726, ENSP00000342232, ENSP00000253024

GeneCards

TRIM28

HPA

ENSG00000130726-TRIM28

PRO

Q13263

Pharos - Targets

Q13263

GlyGen

Q13263

Orphanet

TRIM28

PDB

6H3A, 6QAJ, 6I9H, 2YVR, 6QU1, 1FP0, 2RO1, 7Z36

Interactors (107)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.913	15
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.854	8
UniProt:Q9UBF1 MAGC2			0.792	14
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.788	8
UniProt:P17098 ZNF8			0.725	5
UniProt:Q9BS31 ZNF649	1	ZNF649 [nucleoplasm] (R-HSA-2127585)	0.669	3
UniProt:Q6ZNG0 ZNF620	1	ZNF620 [nucleoplasm] (R-HSA-2127603)	0.669	4
UniProt:P43356 MAGA2			0.668	6
UniProt:P43357 MAGA3			0.646	3
UniProt:O14628 ZNF195	1	ZNF195 [nucleoplasm] (R-HSA-975029)	0.643	5
UniProt:Q6P2D0 ZFP1	1	ZFP1 [nucleoplasm] (R-HSA-974997)	0.643	5
UniProt:O15397 IPO8	2	IPO8 [cytosol] (R-HSA-5578740) IPO8 [nucleoplasm] (R-HSA-5578747)	0.643	4
UniProt:Q8N587 ZNF561	1	ZNF561 [nucleoplasm] (R-HSA-1973888)	0.643	3
UniProt:Q9UK11 ZNF223	1	ZNF223 [nucleoplasm] (R-HSA-1027350)	0.643	3
UniProt:Q96H86 ZNF764	1	ZNF764 [nucleoplasm] (R-HSA-3343766)	0.643	5
UniProt:Q8IZ26 ZNF34	1	ZNF34 [nucleoplasm] (R-HSA-1247510)	0.643	3
UniProt:Q16587 ZNF74	1	ZNF74 [nucleoplasm] (R-HSA-2586601)	0.643	3
UniProt:Q9UPN9 TRIM33	1	TRIM33 [nucleoplasm] (R-HSA-870522)	0.643	4
UniProt:Q8N823 ZNF611	1	ZNF611 [nucleoplasm] (R-HSA-2127573)	0.643	3
UniProt:Q96GC6 ZNF274	1	ZNF274 [nucleoplasm] (R-HSA-1027416)	0.643	5
UniProt:Q14586 ZNF267	1	ZNF267 [nucleoplasm] (R-HSA-1027394)	0.643	5
UniProt:Q96CS4 ZNF689	1	ZNF689 [nucleoplasm] (R-HSA-2248889)	0.643	3
UniProt:Q7L945 ZNF627	1	ZNF627 [nucleoplasm] (R-HSA-2127594)	0.643	3
UniProt:Q14592 ZNF460	1	ZNF460 [nucleoplasm] (R-HSA-1027424)	0.643	6
UniProt:Q969W8 ZNF566	1	ZNF566 [nucleoplasm] (R-HSA-1973878)	0.643	3
UniProt:Q7L2R6 ZNF765	1	ZNF765 [nucleoplasm] (R-HSA-9843524)	0.623	3
UniProt:Q96JL9 ZNF333	1	ZNF333 [nucleoplasm] (R-HSA-1247528)	0.623	4
UniProt:O15164 TRIM24	4	TRIM24(1-510)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802555) TRIM24(1-510)-BRAF(381-766) fusion [cytosol] (R-HSA-6802477) TRIM24(1-626)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839012) TRIM24(1-626)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614442)	0.597	3
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.573	4
UniProt:P52737 ZNF136	1	ZNF136 [nucleoplasm] (R-HSA-975020)	0.564	2
UniProt:P51523 ZNF84			0.564	4
UniProt:Q9BQF6 SENP7			0.564	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.564	2
UniProt:Q9GZX5 ZNF350	1	ZNF350 [nucleoplasm] (R-HSA-1247526)	0.564	2
UniProt:P83917 CBX1			0.564	2
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.556	4
UniProt:P21506 ZNF10	1	ZNF10 [nucleoplasm] (R-HSA-975015)	0.547	3
IntAct:EBI-16203811 H3(1027)			0.544	2
UniProt:Q99608 NDN	1	NDN [nucleoplasm] (R-HSA-6789966)	0.536	2
UniProt:Q14590 ZNF235	1	ZNF235 [nucleoplasm] (R-HSA-1027383)	0.527	2
UniProt:Q96SR6 ZNF382	1	ZNF382 [nucleoplasm] (R-HSA-1247533)	0.527	2
UniProt:A8MTY0 ZNF724	1	ZNF724P [nucleoplasm] (R-HSA-2586597)	0.527	2
UniProt:Q99676 ZNF184	1	ZNF184 [nucleoplasm] (R-HSA-974987)	0.527	2
UniProt:Q9NYW8 RBAK			0.527	3
UniProt:Q77M19 V			0.527	3
UniProt:P59923 ZNF445	1	ZNF445 [nucleoplasm] (R-HSA-1247874)	0.527	3
UniProt:Q86XN6 ZNF761	1	ZNF761 [nucleoplasm] (R-HSA-3323094)	0.527	2
UniProt:O75467 ZNF324	1	ZNF324 [nucleoplasm] (R-HSA-1027431)	0.527	2
UniProt:Q8TF47 ZFP90	1	ZFP90 [nucleoplasm] (R-HSA-974988)	0.527	2
UniProt:Q2VY69 ZN284			0.527	2
UniProt:Q9BSG1 ZNF2	1	ZNF2 [nucleoplasm] (R-HSA-975031)	0.527	2
UniProt:Q9NR11 ZNF302	1	ZNF302 [nucleoplasm] (R-HSA-1027433)	0.527	2
UniProt:Q5T5D7 ZNF684	1	ZNF684 [nucleoplasm] (R-HSA-2248877)	0.527	4
UniProt:A6NFI3 ZN316			0.527	2
UniProt:Q08ER8 ZNF543	1	ZNF543 [nucleoplasm] (R-HSA-1973876)	0.527	2
UniProt:A8K8V0 ZNF785	1	ZNF785 [nucleoplasm] (R-HSA-3323098)	0.527	2
UniProt:Q9HBT7 ZNF287	1	ZNF287 [nucleoplasm] (R-HSA-1027418)	0.527	2
UniProt:Q9P2J8 ZNF624	1	ZNF624 [nucleoplasm] (R-HSA-2127578)	0.527	4
UniProt:Q9P215 POGK			0.527	4
UniProt:Q86Y25 ZNF354C	1	ZNF354C [nucleoplasm] (R-HSA-1247525)	0.527	2
UniProt:Q14684 RRP1B			0.527	2
UniProt:Q8IW36 ZN695			0.527	3
UniProt:A2RRD8 ZNF320	1	ZNF320 [nucleoplasm] (R-HSA-975011)	0.527	4
UniProt:O60765 ZNF354A	1	ZNF354A [nucleoplasm] (R-HSA-1247537)	0.527	4
UniProt:Q3KNS6 ZN829			0.527	3
UniProt:Q9BWM5 ZNF416	1	ZNF416 [nucleoplasm] (R-HSA-1247514)	0.527	2
UniProt:Q5JVG2 ZNF484	1	ZNF484 [nucleoplasm] (R-HSA-1247862)	0.527	2
UniProt:P17017 ZNF14	1	ZNF14 [nucleoplasm] (R-HSA-975030)	0.527	2
UniProt:Q03936 ZNF92	1	ZNF92 [nucleoplasm] (R-HSA-975007)	0.527	2
UniProt:P17014 ZNF12	1	ZNF12(1-501) [nucleoplasm] (R-HSA-974989)	0.527	2
UniProt:Q8NE65 ZNF738	1	ZNF738 [nucleoplasm] (R-HSA-2586594)	0.527	5
UniProt:Q9H707 ZNF552	1	ZNF552 [nucleoplasm] (R-HSA-1973877)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q8IYN0 ZNF100	1	ZNF100 [nucleoplasm] (R-HSA-975035)	0.527	2
UniProt:Q9NZV7 ZIM2	1	ZIM2 [nucleoplasm] (R-HSA-974996)	0.527	3
UniProt:Q8N184 ZNF567	1	ZNF567 [nucleoplasm] (R-HSA-1973892)	0.527	2
UniProt:P15622 ZNF250	1	ZNF250 [nucleoplasm] (R-HSA-1027396)	0.527	4
UniProt:Q5TYW1 ZNF658	1	ZNF658 [nucleoplasm] (R-HSA-2127584)	0.527	4
UniProt:Q9BS34 ZNF670	1	ZNF670 [nucleoplasm] (R-HSA-2248887)	0.527	2
UniProt:Q96K75 ZNF514	1	ZNF514 [nucleoplasm] (R-HSA-1973887)	0.527	2
UniProt:Q8NDW4 ZNF248	1	ZNF248 [nucleoplasm] (R-HSA-1027398)	0.527	2
UniProt:Q9H4L7 SMRCD			0.527	3
UniProt:Q8N4W9 ZN808			0.527	2
UniProt:P17097 ZNF7			0.527	2
UniProt:Q8N988 ZNF557	1	ZNF557 [nucleoplasm] (R-HSA-1973871)	0.527	2
UniProt:P41229 KDM5C	1	KDM5C [nucleoplasm] (R-HSA-4754186)	0.527	3
UniProt:Q7Z398 ZNF550	1	ZNF550 [nucleoplasm] (R-HSA-1973896)	0.527	2
UniProt:Q8WV37 ZNF480	1	ZNF480 [nucleoplasm] (R-HSA-1247871)	0.527	2
UniProt:Q02386 ZNF45	1	ZNF45 [nucleoplasm] (R-HSA-974999)	0.527	2
UniProt:Q5JUW0 KRBOX4	1	KRBOX4 [nucleoplasm] (R-HSA-2248880)	0.527	2
UniProt:Q13398 ZNF211	1	ZNF211 [nucleoplasm] (R-HSA-1027347)	0.527	2
UniProt:Q96GE5 ZNF799	1	ZNF799 [nucleoplasm] (R-HSA-3110244)	0.527	2
UniProt:Q5T7N2 LITD1			0.527	4
UniProt:Q96IR2 ZN845			0.527	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P23198 Cbx3	1	Cbx3 [nucleoplasm] (R-MMU-573362)	0.524	2
UniProt:Q9HCI5 MAGE1			0.524	2
UniProt:P43360 MAGA6			0.524	2
UniProt:Q13568 IRF5	3	IRF5 [cytosol] (R-HSA-1015676) p-S446-IRF5 [cytosol] (R-HSA-9860271) p-S446-IRF5 [nucleoplasm] (R-HSA-9860304)	0.524	5
UniProt:Q14684-1 RRP1B			0.512	4
UniProt:Q9NU63 ZFP57			0.499	2
UniProt:Q6ZSS3 ZNF621	1	ZNF621 [nucleoplasm] (R-HSA-2127582)	0.499	2
IntAct:EBI-2695616 ERE			0.499	2
UniProt:Q8TF47-3 ZFP90			0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2

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