Reactome | TRIM28 [nucleoplasm]

TRIM28 [nucleoplasm]

Stable Identifier

R-HSA-974998

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription intermediary factor 1-beta, TIF1B_HUMAN, KAP1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13263 TRIM28

Gene Names

TRIM28, KAP1, RNF96, TIF1B

Chain

initiator methionine:1, chain:2-835

Reference Genes

BioGPS Gene:10155 TRIM28

COSMIC (genes):TRIM28 TRIM28

CTD Gene:10155 TRIM28

dbSNP Gene:10155 TRIM28

ENSEMBL:ENSG00000130726 TRIM28

HGNC:16384 TRIM28

KEGG Gene (Homo sapiens):10155 TRIM28

Monarch:10155 TRIM28

NCBI Gene:10155 TRIM28

OMIM:601742 TRIM28

UCSC:Q13263 TRIM28

Reference Transcript

RefSeq:NM_005762.2 TRIM28

Other Identifiers

0006450373

10155

11715373_a_at

16866337

200990_at

33425_at

3844240

3844241

3844242

3844243

3844244

3844245

3844249

3844250

3844253

3844254

3844255

3844256

3844257

3844258

3844259

3844261

3844262

3844263

3844264

3844266

3844268

3844269

3844271

3844272

3844273

3844274

3844275

8031913

A_14_P116219

A_23_P89884

GE61192

GO:0000003

GO:0000122

GO:0000228

GO:0000785

GO:0001701

GO:0001837

GO:0002376

GO:0003674

GO:0003677

GO:0003682

GO:0003713

GO:0003714

GO:0003723

GO:0004672

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005719

GO:0005720

GO:0006259

GO:0006281

GO:0006325

GO:0006367

GO:0006464

GO:0006468

GO:0006810

GO:0006913

GO:0006950

GO:0007165

GO:0007265

GO:0007566

GO:0008150

GO:0008270

GO:0009058

GO:0009790

GO:0015031

GO:0016032

GO:0016301

GO:0016567

GO:0016740

GO:0016925

GO:0019789

GO:0019899

GO:0030154

GO:0031625

GO:0032991

GO:0034641

GO:0035851

GO:0040007

GO:0040011

GO:0042307

GO:0043045

GO:0043167

GO:0043226

GO:0043388

GO:0043565

GO:0044403

GO:0045087

GO:0045739

GO:0045869

GO:0045892

GO:0045893

GO:0046777

GO:0046872

GO:0048856

GO:0051276

GO:0060028

GO:0060669

GO:0070087

GO:0090309

GO:0090575

GO:1901536

GO:1902187

GO:1990841

GO:2000653

ILMN_1736575

PH_hs_0025287

TC19000971.hg

U95040_at

g5032178_3p_at

g5032178_3p_x_at

Participant Of

hasComponent

TRIM28:ZNF350 [nucleoplasm]

hasMember

KAP (KRAB-Domain Associated Protein) [nucleoplasm]

This entity regulates

Negatively

Latent Transcriptinally Repressed HCMV Genome

Other forms of this molecule

SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm]

Inferred To

trim33l [nucleoplasm] (Danio rerio)

Dmel\CG8419 [nucleoplasm] (Drosophila melanogaster)

nhl-2 [nucleoplasm] (Caenorhabditis elegans)

TRIM28 [nucleoplasm] (Bos taurus)

TRIM28 [nucleoplasm] (Canis familiaris)

TRIM28 [nucleoplasm] (Dictyostelium discoideum)

TRIM28 [nucleoplasm] (Sus scrofa)

mei-P26 [nucleoplasm] (Drosophila melanogaster)

LOC107050474 [nucleoplasm] (Gallus gallus)

trim28 [nucleoplasm] (Xenopus tropicalis)

Homologues of TRIM28 [nucleoplasm] (Drosophila melanogaster)

Trim28 [nucleoplasm] (Mus musculus)

Trim28 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_005753.1

Target Pathogen

5b354852be737e166372e77d

OpenTargets

ENSG00000130726

GeneCards

Q13263

HPA

ENSG00000130726-TRIM28

Ensembl

ENST00000341753, ENSG00000130726, ENST00000253024, ENSP00000253024, ENSP00000342232

PRO

Q13263

Orphanet

27308

PDB

6QU1, 6I9H, 2YVR, 6QAJ, 6H3A, 2RO1, 1FP0

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P45973 CBX5	2	SUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849) CBX5 [nucleoplasm] (R-HSA-994093)	0.829	10
UniProt:Q9UBF1 MAGC2			0.792	14
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.752	4
UniProt:P43356 MAGA2			0.668	6
UniProt:P43357 MAGA3			0.646	3
UniProt:Q12873 CHD3	2	SUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372) CHD3 [nucleoplasm] (R-HSA-4657012)	0.573	4
UniProt:Q9BQF6 SENP7			0.564	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.564	2
UniProt:P83917 CBX1			0.564	2
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.556	4
IntAct:EBI-16203811 H3(1027)			0.544	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q77M19 Q77M19			0.527	3
UniProt:Q14684 RRP1B			0.527	2
UniProt:Q5T7N2 LITD1			0.527	4
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.527	2
UniProt:Q9HCI5 MAGE1			0.524	2
UniProt:P23198 Cbx3	1	Cbx3 [nucleoplasm] (R-MMU-573362)	0.524	2
UniProt:P43360 MAGA6			0.524	2
UniProt:Q14684-1 RRP1B			0.512	4
IntAct:EBI-2695616 ERE			0.499	2
UniProt:Q8TF47-3 ZFP90			0.499	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2
UniProt:O15164 TRIM24	4	TRIM24-p-2Y-FGFR1 fusion [cytosol] (R-HSA-1839012) TRIM24-FGFR1 fusion [cytosol] (R-HSA-1614442) TRIM24-BRAF fusion [cytosol] (R-HSA-6802477) p-TRIM24-BRAF fusion [cytosol] (R-HSA-6802555)	0.462	2

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