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TRIM28 [nucleoplasm]
Stable Identifier
R-HSA-974998
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription intermediary factor 1-beta, TIF1B_HUMAN, KAP1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Early Events (Homo sapiens)
Latent Transcriptinally Repressed HCMV Genome (Homo sapiens)
TRIM28 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
KRAB-ZNF / KAP Interaction (Homo sapiens)
KAP (KRAB-Domain Associated Protein) [nucleoplasm] (Homo sapiens)
TRIM28 [nucleoplasm] (Homo sapiens)
KRAB-ZNF / KAP Complex [nucleoplasm] (Homo sapiens)
KAP (KRAB-Domain Associated Protein) [nucleoplasm] (Homo sapiens)
TRIM28 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Homo sapiens)
TRIM28 [nucleoplasm] (Homo sapiens)
TRIM28:ZNF350 [nucleoplasm] (Homo sapiens)
TRIM28 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13263 TRIM28
Gene Names
TRIM28, KAP1, RNF96, TIF1B
Chain
initiator methionine:1, chain:2-835
Reference Genes
BioGPS Gene:10155 TRIM28
COSMIC (genes):TRIM28 TRIM28
CTD Gene:10155 TRIM28
dbSNP Gene:10155 TRIM28
ENSEMBL:ENSG00000130726 TRIM28
HGNC:16384 TRIM28
KEGG Gene (Homo sapiens):10155 TRIM28
Monarch:10155 TRIM28
NCBI Gene:10155 TRIM28
OMIM:601742 TRIM28
UCSC:Q13263 TRIM28
Reference Transcript
RefSeq:NM_005762.2 TRIM28
Other Identifiers
0006450373
10155
11715373_a_at
16866337
200990_at
33425_at
3844240
3844241
3844242
3844243
3844244
3844245
3844249
3844250
3844253
3844254
3844255
3844256
3844257
3844258
3844259
3844261
3844262
3844263
3844264
3844266
3844268
3844269
3844271
3844272
3844273
3844274
3844275
8031913
A_14_P116219
A_23_P89884
GE61192
GO:0000003
GO:0000122
GO:0000228
GO:0000785
GO:0001701
GO:0001837
GO:0002376
GO:0003674
GO:0003677
GO:0003682
GO:0003713
GO:0003714
GO:0003723
GO:0004672
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005719
GO:0005720
GO:0006259
GO:0006281
GO:0006325
GO:0006367
GO:0006464
GO:0006468
GO:0006810
GO:0006913
GO:0006950
GO:0007165
GO:0007265
GO:0007566
GO:0008150
GO:0008270
GO:0009058
GO:0009790
GO:0015031
GO:0016032
GO:0016301
GO:0016567
GO:0016740
GO:0016925
GO:0019789
GO:0019899
GO:0030154
GO:0031625
GO:0032991
GO:0034641
GO:0035851
GO:0040007
GO:0040011
GO:0042307
GO:0043045
GO:0043167
GO:0043226
GO:0043388
GO:0043565
GO:0044403
GO:0045087
GO:0045739
GO:0045869
GO:0045892
GO:0045893
GO:0046777
GO:0046872
GO:0048856
GO:0051276
GO:0060028
GO:0060669
GO:0070087
GO:0090309
GO:0090575
GO:1901536
GO:1902187
GO:1990841
GO:2000653
ILMN_1736575
PH_hs_0025287
TC19000971.hg
U95040_at
g5032178_3p_at
g5032178_3p_x_at
Participant Of
hasComponent
TRIM28:ZNF350 [nucleoplasm]
hasMember
KAP (KRAB-Domain Associated Protein) [nucleoplasm]
This entity regulates
Negatively
Latent Transcriptinally Repressed HCMV Genome
Other forms of this molecule
SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm]
Inferred To
trim33l [nucleoplasm] (Danio rerio)
Dmel\CG8419 [nucleoplasm] (Drosophila melanogaster)
nhl-2 [nucleoplasm] (Caenorhabditis elegans)
TRIM28 [nucleoplasm] (Bos taurus)
TRIM28 [nucleoplasm] (Canis familiaris)
TRIM28 [nucleoplasm] (Dictyostelium discoideum)
TRIM28 [nucleoplasm] (Sus scrofa)
mei-P26 [nucleoplasm] (Drosophila melanogaster)
LOC107050474 [nucleoplasm] (Gallus gallus)
trim28 [nucleoplasm] (Xenopus tropicalis)
Homologues of TRIM28 [nucleoplasm] (Drosophila melanogaster)
Trim28 [nucleoplasm] (Mus musculus)
Trim28 [nucleoplasm] (Rattus norvegicus)
Cross References
RefSeq
NP_005753.1
Target Pathogen
5b354852be737e166372e77d
OpenTargets
ENSG00000130726
GeneCards
Q13263
HPA
ENSG00000130726-TRIM28
Ensembl
ENSP00000342232
,
ENSP00000253024
,
ENST00000341753
,
ENST00000253024
,
ENSG00000130726
PRO
Q13263
Orphanet
27308
PDB
6QU1
,
2YVR
,
6I9H
,
1FP0
,
6QAJ
,
2RO1
,
6H3A
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P45973 CBX5
2
SUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
CBX5 [nucleoplasm]
(R-HSA-994093)
0.869
11
UniProt:Q9UBF1 MAGC2
0.792
14
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.752
4
UniProt:P43356 MAGA2
0.668
6
UniProt:P43357 MAGA3
0.646
3
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.643
3
UniProt:Q12873 CHD3
2
SUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
CHD3 [nucleoplasm]
(R-HSA-4657012)
0.573
4
UniProt:Q9BQF6 SENP7
0.564
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.564
2
UniProt:P83917 CBX1
0.564
2
UniProt:O75376 NCOR1
2
NCOR1 [cytosol]
(R-HSA-1253310)
NCOR1 [nucleoplasm]
(R-HSA-442501)
0.556
4
IntAct:EBI-16203811 H3(1027)
0.544
2
UniProt:Q77M19 Q77M19
0.527
3
UniProt:Q14684 RRP1B
0.527
2
UniProt:Q5T7N2 LITD1
0.527
4
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q9HCI5 MAGE1
0.524
2
UniProt:P23198 Cbx3
1
Cbx3 [nucleoplasm]
(R-MMU-573362)
0.524
2
UniProt:P43360 MAGA6
0.524
2
UniProt:Q14684-1 RRP1B
0.512
4
IntAct:EBI-2695616 ERE
0.499
2
UniProt:Q8TF47-3 ZFP90
0.499
2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]
6
PI(4,5)P2 [Golgi membrane]
(R-ALL-1806165)
PI(4,5)P2 [plasma membrane]
(R-ALL-179856)
PI(4,5)P2 [endoplasmic reticulum membrane]
(R-ALL-2023856)
PI(4,5)P2 [nucleoplasm]
(R-ALL-6810412)
PI(4,5)P2 [cytoplasmic vesicle membrane]
(R-ALL-8874467)
PI(4,5)P2 [early endosome membrane]
(R-ALL-8849966)
0.462
2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]
7
PI(3,5)P2 [plasma membrane]
(R-ALL-1806224)
PI(3,5)P2 [phagophore assembly site membrane]
(R-ALL-5692959)
PI(3,5)P2 [Golgi membrane]
(R-ALL-1806290)
PI(3,5)P2 [early endosome membrane]
(R-ALL-1806205)
PI(3,5)P2 [late endosome membrane]
(R-ALL-1806289)
PI(3,5)P2 [endoplasmic reticulum membrane]
(R-ALL-6809774)
PI(3,5)P2 [lysosomal membrane]
(R-ALL-5334668)
0.462
2
UniProt:O15164 TRIM24
4
TRIM24-p-2Y-FGFR1 fusion [cytosol]
(R-HSA-1839012)
TRIM24-FGFR1 fusion [cytosol]
(R-HSA-1614442)
TRIM24-BRAF fusion [cytosol]
(R-HSA-6802477)
p-TRIM24-BRAF fusion [cytosol]
(R-HSA-6802555)
0.462
2
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