Drug-induced formation of DNA interstrand crosslinks

Stable Identifier
R-HSA-9750126
DOI
10.3180/R-HSA-9750126.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Drug-induced formation of DNA interstrand crosslinks
Click the image above or here to open this pathway in the Pathway Browser
This pathway describes how drugs commonly used in the treatment of cancer, psoriasis and severe atopic dermatitis produce DNA interstrand crosslinks that are repaired through the Fanconi anemia pathway. For review, please refer to Deans and West 2011, Fu et al. 2012, and Rycenga and Long 2018.
Literature References
PubMed ID Title Journal Year
21701511 DNA interstrand crosslink repair and cancer

West, SC, Deans, AJ

Nat. Rev. Cancer 2011
29679802 The evolving role of DNA inter-strand crosslinks in chemotherapy

Rycenga, HB, Long, DT

Curr Opin Pharmacol 2018
22237395 Balancing repair and tolerance of DNA damage caused by alkylating agents

Fu, D, Samson, LD, Calvo, JA

Nat. Rev. Cancer 2012
Participants
Events
Participates
as an event of
Authored
Orlic-Milacic, M  (2021-02-01)
Reviewed
Kadambat Nair, S  (2021-07-28)
Created
Orlic-Milacic, M  (2021-08-09)
Cite Us!