ABCC4 transports TPMP substrates from cytosol to extracellular region

Stable Identifier
Reaction [transition]
Homo sapiens
ABCC4 transports thiopurine monophosphates from cytosol to extracellular region
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ABCC4 is a multidrug resistance protein (MRP4) which can transport a wide range of organic anions but especially nucleotides and nucleotide analogues. When overexpressed, ABCC4 can lower the intracellular concentration of nucleoside/nucleotide analogues such as 6-mercaptopurine (6MP), after its conversion into its respective nucleotides (Wielinga et al. 2002, Ritter et al. 2005, Peng et al. 2008). This may lead to an impaired ability of 6MP to inhibit cell proliferation.
Literature References
PubMed ID Title Journal Year
17996297 Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine

Fu, L, Damaraju, VL, Chen, ZS, Shi, Z, Cass, CE, Wu, HC, Peng, XX, Zhou, Y, Tiwari, A, Kruh, GD, Huang, XC

Leuk Res 2008
15747503 Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5)

Kroemer, HK, Köck, K, Meyer zu Schwabedissen, H, Ritter, CA, Jedlitschky, G, Grube, M

Drug Metab Rev 2005
12435799 Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells

Borst, P, Challa, EE, van Deemter, L, De Abreu, RA, Schuetz, JD, Wielinga, PR, Beijnen, JH, de Haas, M, Wijnholds, J, van der Heijden, I, Groeneveld, E, Brouwer, C, Mol, C, Kuil, AJ, Reid, G

Mol Pharmacol 2002
Event Information
Catalyst Activity

ATPase-coupled transmembrane transporter activity of ABCC4 [plasma membrane]

Orthologous Events
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