ABCC5 transports TPMP substrates from cytosol to extracellular region

Stable Identifier
Reaction [transition]
Homo sapiens
ABCC5 transports thiopurine monophosphates from cytosol to extracellular region
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ABCC5 is a multidrug resistance protein (MRP5) which can transport a wide range of organic anions but especially nucleotides and nucleotide analogues. When overexpressed, ABCC5 can lower the intracellular concentration of nucleoside/nucleotide analogues such as 6-mercaptopurine (6MP), after its conversion into its respective nucleotides (Wijnholds et al. 2000, Ritter et al. 2005, Peng et al. 2008). This may lead to an impaired ability of 6MP to inhibit cell proliferation.
Literature References
PubMed ID Title Journal Year
10840050 Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

Beijnen, JH, Hatse, S, de Haas, M, Scheffer, GL, Scheper, RJ, De Clercq, E, Mol, CA, Wijnholds, J, Borst, P, van Deemter, L, Baas, F, Balzarini, J

Proc Natl Acad Sci U S A 2000
15747503 Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5)

Kroemer, HK, Köck, K, Meyer zu Schwabedissen, H, Ritter, CA, Jedlitschky, G, Grube, M

Drug Metab Rev 2005
12435799 Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells

Borst, P, Challa, EE, van Deemter, L, De Abreu, RA, Schuetz, JD, Wielinga, PR, Beijnen, JH, de Haas, M, Wijnholds, J, van der Heijden, I, Groeneveld, E, Brouwer, C, Mol, C, Kuil, AJ, Reid, G

Mol Pharmacol 2002
Event Information
Catalyst Activity

ATPase-coupled transmembrane transporter activity of ABCC5 [plasma membrane]

Orthologous Events
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