SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
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Candidates for the transport of thiopurines like 6-mercaptopurine (6MP) into the cell include the sodium-dependent transporters SLC28A2 (concentrative Na(+)-nucleoside cotransporter 2, CNT2) and SLC28A3 (concentrative Na(+)-nucleoside cotransporter 3, CNT3). Down-regulation of these influx transporters may play a major role in 6MP resistance of cells (Fotoohi et al. 2006, Peng et al. 2008, Karim et al. 2011).
Literature References
PubMed ID Title Journal Year
17996297 Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine

Fu, L, Damaraju, VL, Chen, ZS, Shi, Z, Cass, CE, Wu, HC, Peng, XX, Zhou, Y, Tiwari, A, Kruh, GD, Huang, XC

Leuk Res 2008
16530731 Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines

Peterson, C, Fotoohi, AK, Albertioni, F, Lindqvist, M

Biochem Biophys Res Commun 2006
21723252 The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells

Moshfegh, A, Hashemi, J, Larsson, C, Karim, H, Albertioni, F, Fotoohi, AK

Biochem Biophys Res Commun 2011
Event Information
Catalyst Activity

nucleoside:sodium symporter activity of SLC28A2,3 [plasma membrane]

Orthologous Events
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