TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

Stable Identifier
R-HSA-975138
Type
Pathway
Species
Homo sapiens
Compartment
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TRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.

Literature References
PubMed ID Title Journal Year
18794297 The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation

Fraczek, J, Kim, TW, Xiao, H, Yao, J, Wen, Q, Li, Y, Casanova, JL, Pryjma, J, Li, X

J. Biol. Chem. 2008
22511786 Essential role for IKK? in production of type 1 interferons by plasmacytoid dendritic cells

Pauls, E, Shpiro, N, Peggie, M, Young, ER, Sorcek, RJ, Tan, L, Choi, HG, Cohen, P

J. Biol. Chem. 2012
Participants
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Orthologous Events
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BioModels Database
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