Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs.
Hanten, JA, Vasilakos, JP, Riter, CL, Neys, L, Lipson, KE, Alkan, SS, Birmachu, W
Cherfils-Vicini, J, Platonova, S, Gillard, M, Laurans, L, Validire, P, Caliandro, R, Magdeleinat, P, Mami-Chouaib, F, Dieu-Nosjean, MC, Fridman, WH, Damotte, D, Sautès-Fridman, C, Cremer, I
Gangloff, M, Gay, NJ
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