MyD88 dependent cascade initiated on endosome

Stable Identifier
R-HSA-975155
Type
Pathway
Species
Homo sapiens
Compartment
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Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs.

Literature References
PubMed ID Title Journal Year
18652679 Comparison of human B cell activation by TLR7 and TLR9 agonists

Hanten, JA, Vasilakos, JP, Riter, CL, Neys, L, Lipson, KE, Alkan, SS, Birmachu, W

BMC Immunol. 2008
20237413 Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance

Cherfils-Vicini, J, Platonova, S, Gillard, M, Laurans, L, Validire, P, Caliandro, R, Magdeleinat, P, Mami-Chouaib, F, Dieu-Nosjean, MC, Fridman, WH, Damotte, D, Saut├Ęs-Fridman, C, Cremer, I

J. Clin. Invest. 2010
15276183 MD-2: the Toll 'gatekeeper' in endotoxin signalling

Gangloff, M, Gay, NJ

Trends Biochem Sci 2004
Participants
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Orthologous Events
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BioModels Database
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