IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Human immunodeficiency virus 1, Influenza A virus, Human SARS coronavirus, Severe acute respiratory syndrome coronavirus 2
Locations in the PathwayBrowser
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IRAK4 is the mammalian homolog of Drosophila melanogaster Tube [Towb P et al 2009; Moncrieffe MC et al 2008]. Like Tube, IRAK4 possesses a conserved N-terminal death domain (DD), which mediates interactions with MyD88 at one binding site and a downstream IRAK kinase at the other, thereby bridging MyD88 and IRAK1/2 association [Towb P et al 2009; Lin SC e al 2010]. IRAK-4 plays a critical role in Toll receptor signaling - any interference with IRAK-4's kinase activity virtually abolishes downstream events. This is not the case with other members of the IRAK family [Suzuki N et al 2002; Li S et al 2002].
Literature References
PubMed ID Title Journal Year
12297423 IRAK-4 as the central TIR signaling mediator in innate immunity

Suzuki, S, Yeh, WC, Suzuki, N

Trends Immunol 2002
16286015 Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses

Ozinsky, A, Casrouge, A, Li, X, von Bernuth, H, Lebon, P, Davidson, D, Al-Hajjar, S, Roifman, C, Plancoulaine, S, Barrat, FJ, Sénéchal, B, Miller, RL, Geissmann, F, Speert, D, Ku, CL, Rodriguez-Gallego, C, Yang, K, Jouanguy, E, Zhang, S, Garty, BZ, Puel, A, Al-Ghonaium, A, Picard, C, Eidenschenk, C, Maródi, L, Chapel, H, Coffman, RL, Casanova, JL

Immunity 2005
18794297 The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation

Kim, TW, Li, X, Wen, Q, Li, Y, Xiao, H, Yao, J, Casanova, JL, Fraczek, J, Pryjma, J

J. Biol. Chem. 2008
11960013 IRAK-4: a novel member of the IRAK family with the properties of an

Wesche, H, Li, S, Fontana, EJ, Strelow, A

Proc Natl Acad Sci U S A 2002
Orthologous Events
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