Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9

Stable Identifier
R-HSA-975160
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1, Influenza A virus, Human SARS coronavirus, Severe acute respiratory syndrome coronavirus 2
Compartment
ReviewStatus
5/5
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IRAK4 deficient macrophages fail to induce IRAK2 phosphorylation (Kawagoe et al. 2008), suggesting that activated IRAK4 phosphorylates IRAK2 as it does IRAK1.

Phosphorylation sites of IRAK2 remain to be characterized.

Literature References
PubMed ID Title Journal Year
18438411 Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2

Kumagai, Y, Kawai, T, Takeuchi, O, Saitoh, T, Matsushita, K, Sato, S, Akira, S, Matsui, K, Kato, H, Kawagoe, T

Nat Immunol 2008
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane]

Orthologous Events
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