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p-IRAK2 [endosome membrane]
Stable Identifier
R-HSA-975187
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
Interleukin-1 receptor-associated kinase-like 2, IRAK2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
hp-IRAK1/p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
hp-IRAK1/p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
hp-IRAK1/p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
hp-IRAK1/or p-IRAK2 :TRAF6 [endosome membrane] (Homo sapiens)
hp-IRAK1/p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [endosome membrane] (Homo sapiens)
TRAF6:p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)
TRAF6:p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [endosome membrane] (Homo sapiens)
TRAF6:p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
hp-IRAK1/p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
hp-IRAK1/p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
hp-IRAK1/p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
hp-IRAK1/or p-IRAK2 :TRAF6 [endosome membrane] (Homo sapiens)
hp-IRAK1/p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [endosome membrane] (Homo sapiens)
TRAF6:p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)
TRAF6:p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [endosome membrane] (Homo sapiens)
TRAF6:p-IRAK2 [endosome membrane] (Homo sapiens)
p-IRAK2 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43187 IRAK2
Gene Names
IRAK2
Chain
chain:1-625
Reference Genes
BioGPS Gene:3656 IRAK2
COSMIC (genes):IRAK2 IRAK2
CTD Gene:3656 IRAK2
dbSNP Gene:3656 IRAK2
ENSEMBL:ENSG00000134070 IRAK2
HGNC:6113 IRAK2
KEGG Gene (Homo sapiens):3656 IRAK2
Monarch:3656 IRAK2
NCBI Gene:3656 IRAK2
OMIM:603304 IRAK2
UCSC:O43187 IRAK2
Reference Transcript
RefSeq:NM_001570.3 IRAK2
Other Identifiers
0003170082
11733240_at
11733241_at
1553740_a_at
16937579
231779_at
2610360
2610361
2610365
2610367
2610368
2610369
2610370
2610371
2610373
2610375
2610376
2610377
2610380
2610383
2610385
2610386
2610387
2610388
2610390
2610391
3656
76762_at
8077786
A_23_P80635
A_33_P3352970
GE62955
GO:0000166
GO:0000187
GO:0001959
GO:0002224
GO:0002755
GO:0003674
GO:0004672
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006950
GO:0006954
GO:0007165
GO:0007249
GO:0007254
GO:0008150
GO:0009058
GO:0010008
GO:0016301
GO:0019221
GO:0031410
GO:0031663
GO:0032088
GO:0034162
GO:0034641
GO:0035556
GO:0042803
GO:0043167
GO:0043226
GO:0043433
GO:0046982
GO:0051092
GO:0070423
GO:0070498
GO:0070555
HMNXSV003031884
HMNXSV003036195
Hs.249175.0.S2_3p_at
ILMN_1745964
PH_hs_0019808
TC03000056.hg
Participates
as a component of
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
TRAF6:p-IRAK2 [endosome membrane] (Homo sapiens)
as a member of
hp-IRAK1/p-IRAK2 [endosome membrane] (Homo sapiens)
Other forms of this molecule
IRAK2 [endosome membrane]
IRAK2 [plasma membrane]
IRAK2 [cytosol]
p-IRAK2 [plasma membrane]
p-IRAK2 [cytosol]
Inferred To
phospho-Irak2 [endosome membrane]
(Mus musculus)
phospho-Irak2 [endosome membrane]
(Rattus norvegicus)
phospho-irak1 [endosome membrane]
(Danio rerio)
phospho-p-IRAK2 [endosome membrane]
(Dictyostelium discoideum)
phospho-IRAK2 [endosome membrane]
(Canis familiaris)
phospho-IRAK2 [endosome membrane]
(Gallus gallus)
phospho-IRAK2 [endosome membrane]
(Sus scrofa)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_001561.3
OpenTargets
ENSG00000134070
HPA
ENSG00000134070-IRAK2
GeneCards
O43187
Ensembl
ENSG00000134070
,
ENST00000256458
,
ENSP00000256458
PRO
O43187
HMDB Protein
HMDBP09473
PDB
3MOP
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
0.752
4
UniProt:Q9NWZ3 IRAK4
9
IRAK4 Q293TER [cytosol]
(R-HSA-5602426)
IRAK4 R12C [cytosol]
(R-HSA-5602511)
IRAK4 E402TER [cytosol]
(R-HSA-5602517)
p-T342,T345,S346-IRAK4 [cytosol]
(R-HSA-446649)
IRAK4 [endosome membrane]
(R-HSA-975167)
p-T342,T345,S346-IRAK4 [endosome membrane]
(R-HSA-975149)
IRAK4 [plasma membrane]
(R-HSA-937051)
p-T342,T345,S346-IRAK4 [plasma membrane]
(R-HSA-936957)
IRAK4 [cytosol]
(R-HSA-166081)
0.711
6
UniProt:Q99836-1 MYD88
0.576
3
UniProt:Q9Y616 IRAK3
1
IRAK3 [cytosol]
(R-HSA-166103)
0.564
3
UniProt:P58753 TIRAP
2
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
TIRAP [cytosol]
(R-HSA-166141)
0.564
2
UniProt:P51617 IRAK1
14
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
IRAK1 [plasma membrane]
(R-HSA-937045)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
IRAK1 [cytosol]
(R-HSA-446639)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
0.564
3
UniProt:Q86VW0 SESD1
0.527
2
UniProt:P68467 K7
0.524
2
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S576 ARAF [plasma membrane]
(R-HSA-5672648)
p-S299,S302,T452,T455,S576 ARAF [cytosol]
(R-HSA-5672646)
p-S576 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S576 ARAF [cytosol]
(R-HSA-5672639)
0.499
2
UniProt:P46977 STT3A
1
STT3A [endoplasmic reticulum membrane]
(R-HSA-265023)
0.499
2
UniProt:Q5D1E8 ZC12A
0.499
2
UniProt:Q13148 TADBP
0.499
2
UniProt:Q9H0E2 TOLLIP
4
TOLLIP [azurophil granule lumen]
(R-HSA-6799709)
TOLLIP [cytosol]
(R-HSA-446885)
TOLLIP [extracellular region]
(R-HSA-6800448)
TOLLIP [specific granule lumen]
(R-HSA-6799719)
0.499
2
UniProt:Q6PDS3
1
Sarm1 [cytosol]
(R-MMU-2559572)
0.499
2
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