Reactome | KCNJ15 [plasma membrane]

KCNJ15 [plasma membrane]

Stable Identifier

R-HSA-975292

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ATP-sensitive inward rectifier potassium channel 15, IRK15_HUMAN, Kir 4.2

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Inwardly rectifying K+ channels (Homo sapiens)
    - G protein gated Potassium channels (Homo sapiens)
      - Activation of G protein gated Potassium channels (Homo sapiens)
        
        Activation of GIRK/Kir3 Channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir4.2:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ15 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir4.2:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ15 [plasma membrane] (Homo sapiens)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir4.2:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ15 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir4.2:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ15 [plasma membrane] (Homo sapiens)
- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Homo sapiens)
        
        Activation of GIRK/Kir3 Channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir4.2:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ15 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir4.2:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ15 [plasma membrane] (Homo sapiens)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir4.2:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ15 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir4.2:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ15 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99712 KCNJ15

Gene Names

KCNJ15, KCNJ14

Chain

chain:1-375

Reference Genes

BioGPS Gene:3772 KCNJ15

COSMIC (genes):KCNJ15 KCNJ15

CTD Gene:3772 KCNJ15

dbSNP Gene:3772 KCNJ15

ENSEMBL:ENSG00000157551 KCNJ15

ENSEMBL_homo_sapiens_GENE:ENSG00000157551.19 KCNJ15

HGNC:6261 KCNJ15

KEGG Gene (Homo sapiens):3772 KCNJ15

Monarch:3772 KCNJ15

NCBI Gene:3772 KCNJ15

OMIM:602106 KCNJ15

UCSC:Q99712 KCNJ15

Reference Transcript

Other Identifiers

11732454_at

11732455_at

16922759

210119_PM_at

210119_at

211806_PM_s_at

211806_s_at

230585_PM_at

230585_at

238428_PM_at

238428_at

239464_PM_at

239464_at

35472_at

3772

3920855

3920856

3920857

3920865

3920871

3920874

3920875

3920876

3920877

3920878

3920879

3920880

3920881

3920882

3920883

3920884

3920885

3920886

3920887

3920888

66397_r_at

74485_at

8068583

81474_at

A_23_P17655

A_33_P3267532

A_33_P3376140

GE493497

GE58277

GE894303

GO:0005215

GO:0005242

GO:0005515

GO:0005886

GO:0006811

GO:0006813

GO:0016020

GO:0034220

GO:0034702

GO:0034765

GO:0055085

GO:1990573

HMNXSV003006906

Hs.129583.0.A1_3p_at

Hs.157528.0.A1_3p_at

Hs.257676.0.A1_3p_at

ILMN_1659770

ILMN_1675756

ILMN_2396903

PH_hs_0001570

TC21000167.hg

TC21000717.hg

U73191_at

Y13896_at

g1765984_3p_at

g1772441_3p_a_at

Participates

as a component of

Kir4.2:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)

Inferred To

Kcnj15 [plasma membrane] (Mus musculus)

Kcnj15 [plasma membrane] (Rattus norvegicus)

irk-2 [plasma membrane] (Caenorhabditis elegans)

Homologues of KCNJ15 [plasma membrane] (Caenorhabditis elegans)

Homologues of KCNJ15 [plasma membrane] (Drosophila melanogaster)

Irk1 [plasma membrane] (Drosophila melanogaster)

irk-3 [plasma membrane] (Caenorhabditis elegans)

KCNJ15 [plasma membrane] (Bos taurus)

KCNJ15 [plasma membrane] (Canis familiaris)

KCNJ15 [plasma membrane] (Gallus gallus)

KCNJ15 [plasma membrane] (Sus scrofa)

Irk3 [plasma membrane] (Drosophila melanogaster)

irk-1 [plasma membrane] (Caenorhabditis elegans)

Irk2 [plasma membrane] (Drosophila melanogaster)

kcnj15 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001263364.1, NP_733932.1, NP_001263365.1, XP_005261032.1, NP_733933.1, XP_016883833.1, XP_011527863.1, XP_016883832.1, XP_016883834.1, NP_002234.2, NP_001263366.1, NP_001263367.1, XP_011527862.1, NP_001263368.1, XP_006724065.1

Guide to Pharmacology - Targets

439

OpenTargets

ENSG00000157551

HPA

ENSG00000157551-KCNJ15

GeneCards

Q99712

Ensembl

ENST00000398930, ENST00000398932, ENSP00000479100, ENST00000612702, ENSP00000381911, ENSP00000381905, ENST00000398938, ENSG00000157551, ENSP00000381904, ENST00000328656, ENST00000613499, ENSP00000381907, ENSP00000331698, ENSP00000484960, ENST00000398934

PRO

Q99712

Pharos - Targets

Q99712

HMDB Protein

HMDBP08739

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63252 KCNJ2	1	KCNJ2 [plasma membrane] (R-HSA-975378)	0.556	3
UniProt:O54824	4	Il16 [extracellular region] (R-MMU-447098) Il16 [cytosol] (R-MMU-449094) Il16 [cytosol] (R-MMU-449075) Il16 [cytosol] (R-MMU-449071)	0.527	2