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KCNJ4 [plasma membrane]
Stable Identifier
R-HSA-975336
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Inward rectifier potassium channel 4, IRK4_HUMAN
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Phase 4 - resting membrane potential (Homo sapiens)
KCNJs transport K+ from the extracellular region to cytosol (Homo sapiens)
KCNJ tetramer [plasma membrane] (Homo sapiens)
KCNJs [plasma membrane] (Homo sapiens)
KCNJ4 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Potassium Channels (Homo sapiens)
Inwardly rectifying K+ channels (Homo sapiens)
Classical Kir channels (Homo sapiens)
KCNJs transport K+ from the extracellular region to cytosol (Homo sapiens)
KCNJ tetramer [plasma membrane] (Homo sapiens)
KCNJs [plasma membrane] (Homo sapiens)
KCNJ4 [plasma membrane] (Homo sapiens)
G protein gated Potassium channels (Homo sapiens)
Activation of G protein gated Potassium channels (Homo sapiens)
Activation of GIRK/Kir3 Channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ4 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ4 [plasma membrane] (Homo sapiens)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ4 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ4 [plasma membrane] (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
GABA receptor activation (Homo sapiens)
GABA B receptor activation (Homo sapiens)
Activation of GABAB receptors (Homo sapiens)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Homo sapiens)
Activation of GIRK/Kir3 Channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ4 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ4 [plasma membrane] (Homo sapiens)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ4 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48050 KCNJ4
Gene Names
KCNJ4, IRK3
Chain
chain:1-445
Reference Genes
BioGPS Gene:3761 KCNJ4
COSMIC (genes):KCNJ4 KCNJ4
CTD Gene:3761 KCNJ4
dbSNP Gene:3761 KCNJ4
ENSEMBL:ENSG00000168135 KCNJ4
HGNC:6265 KCNJ4
KEGG:hsa:3761 KCNJ4
Monarch:3761 KCNJ4
NCBI Gene:3761 KCNJ4
OMIM:600504 KCNJ4
UCSC:P48050 KCNJ4
Reference Transcript
RefSeq:NM_004981.1 KCNJ4
RefSeq:NM_152868.2 KCNJ4
Other Identifiers
11740185_at
16935036
208359_PM_s_at
208359_s_at
211451_3p_s_at
211451_PM_s_at
211451_s_at
36285_at
3761
3960606
3960607
3960608
3960609
3960610
3960611
3960612
3960616
75181_f_at
8076072
A_24_P6125
GE62702
GO:0005215
GO:0005242
GO:0005515
GO:0005886
GO:0006813
GO:0008076
GO:0016020
GO:0016323
GO:0030165
GO:0030659
GO:0031410
GO:0034220
GO:0034702
GO:0034765
GO:0043226
GO:0045202
GO:0045211
GO:0055085
GO:1990573
HMNXSV003029881
ILMN_1697620
ILMN_1800179
PH_hs_0002747
S72503_s_at
TC22000790.hg
U24056_s_at
g4826797_3p_s_at
g775226_3p_s_at
Participates
as a member of
KCNJs [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
Inferred To
Kcnj4 [plasma membrane]
(Mus musculus)
Kcnj4 [plasma membrane]
(Rattus norvegicus)
KCNJ4 [plasma membrane]
(Bos taurus)
KCNJ4 [plasma membrane]
(Gallus gallus)
KCNJ4 [plasma membrane]
(Sus scrofa)
irk-2 [plasma membrane]
(Caenorhabditis elegans)
Irk1 [plasma membrane]
(Drosophila melanogaster)
kcnj4 [plasma membrane]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
432
ENSEMBL
ENSP00000306497
,
ENST00000303592
OpenTargets
ENSG00000168135
HPA
ENSG00000168135-KCNJ4
ZINC - Substances
KCNJ4_HUMAN
ZINC target
P48050
PRO
P48050
Pharos - Targets
P48050
HMDB Protein
HMDBP08742
PDB
3GJ9
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.609
2
UniProt:Q62696 Dlg1
4
Dlg1 [plasma membrane]
(R-RNO-9617427)
Dlg1 [endoplasmic reticulum membrane]
(R-RNO-9610616)
Dlg1 [cytosol]
(R-RNO-416332)
Dlg1 [plasma membrane]
(R-RNO-375977)
0.564
2
UniProt:Q9HAP6 LIN7B
2
LIN7B [plasma membrane]
(R-HSA-5216107)
LIN7B [transport vesicle membrane]
(R-HSA-9610415)
0.508
3
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