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APAP translocates from extracellular region to cytosol
Stable Identifier
R-HSA-9754180
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Drug ADME (Homo sapiens)
Paracetamol ADME (Homo sapiens)
APAP translocates from extracellular region to cytosol (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Paracetamol (APAP) is a weak acid (pKa ~9.5) so at physiological pH it is mostly neutral and can be rapidly absorbed from the duodenum into the bloodstream and from there into hepatocytes. The rate of gastric emptying can be used as a measure of plasma APAP levels (Nimmo et al. 1973, Heading et al. 1983). In humans, the half-life of APAP in blood after a therapeutic dose is 1.5hrs to 3hrs (Cummings et al. 1967).
Literature References
PubMed ID
Title
Journal
Year
4694406
Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption
Nimmo, J
,
Prescott, LF
,
Heading, RC
,
Tothill, P
Br Med J
1973
6032053
A kinetic study of drug elimination: the excretion of paracetamol and its metabolites in man
Martin, BK
,
Cummings, AJ
,
King, ML
Br J Pharmacol Chemother
1967
4722050
The dependence of paracetamol absorption on the rate of gastric emptying
Nimmo, J
,
Prescott, LF
,
Heading, RC
,
Tothill, P
Br J Pharmacol
1973
Participants
Input
APAP [extracellular region]
Output
APAP [cytosol]
Participates
as an event of
Paracetamol ADME (Homo sapiens)
Authored
Jassal, B (2021-09-21)
Reviewed
Huddart, R (2021-10-13)
Created
Jassal, B (2021-09-21)
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