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ASB7 [cytosol]
Stable Identifier
R-HSA-975425
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ankyrin repeat and SOCS box protein 7, ASB7_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H672 ASB7
Gene Names
ASB7
Chain
chain:1-318
Reference Genes
BioGPS Gene:140460 ASB7
COSMIC (genes):ASB7 ASB7
CTD Gene:140460 ASB7
dbSNP Gene:140460 ASB7
ENSEMBL:ENSG00000183475 ASB7
HGNC:17182 ASB7
KEGG:hsa:140460 ASB7
Monarch:140460 ASB7
NCBI Gene:140460 ASB7
OMIM:615052 ASB7
UCSC:Q9H672 ASB7
Reference Transcript
RefSeq:NM_198243.2 ASB7
RefSeq:NM_024708.3 ASB7
Other Identifiers
11723869_s_at
11723870_at
11730679_a_at
140460
16805663
219996_PM_at
219996_at
226513_PM_at
226513_at
3611507
3611508
3611509
3611510
3611511
3611512
3611513
3611514
3611515
3611516
3611517
3611518
3611519
3611520
3611521
3611524
3611525
3611526
3611527
44671_at
57293_at
57296_g_at
59151_at
61475_at
64775_at
7986433
A_14_P133973
A_23_P117743
A_24_P155791
A_24_P920979
GE82906
GO:0005515
GO:0005829
GO:0016567
GO:0035556
HMNXSV003037159
HMNXSV003047669
Hs.31845.0.A1_3p_at
ILMN_1680419
ILMN_1744050
ILMN_1753040
PH_hs_0035834
TC15000967.hg
g13376002_3p_at
Participates
as a member of
CUL5-box protein [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
Inferred To
ANKRD44 [cytosol]
(Canis familiaris)
Charon [cytosol]
(Drosophila melanogaster)
ASB7 [cytosol]
(Bos taurus)
ASB7 [cytosol]
(Dictyostelium discoideum)
ASB7 [cytosol]
(Gallus gallus)
ASB7 [cytosol]
(Schizosaccharomyces pombe)
ASB7 [cytosol]
(Sus scrofa)
ikb-1 [cytosol]
(Caenorhabditis elegans)
Asb7 [cytosol]
(Mus musculus)
Asb7 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_078984.2
,
NP_937886.1
ENSEMBL
ENST00000332783
,
ENSP00000339819
,
ENST00000343276
,
ENSP00000328327
OpenTargets
ENSG00000183475
HPA
ENSG00000183475-ASB7
PRO
Q9H672
Pharos - Targets
Q9H672
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.744
5
UniProt:Q9UBF6 RNF7
1
RNF7 (RBX2) [cytosol]
(R-HSA-8863132)
0.564
4
UniProt:Q15643 TRIP11
4
TRIP11 [transport vesicle]
(R-HSA-8847847)
TRIP11 [Golgi membrane]
(R-HSA-5617602)
TRIP11(2-1724)-FLT3(594-993) fusion [cytosol]
(R-HSA-9703323)
TRIP11(2-1724)-p-4Y-FLT3(594-993) fusion [cytosol]
(R-HSA-9703304)
0.527
3
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.527
2
UniProt:O00253 AGRP
1
AGRP [nucleoplasm]
(R-HSA-9623016)
0.527
2
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