Reactome | SKP2 [nucleoplasm]

SKP2 [nucleoplasm]

Stable Identifier

R-HSA-975554

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

S-phase kinase-associated protein 2, SKP2_HUMAN

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP13 binds UFD1L:SKP2 (Homo sapiens)
        
        UFD1L:SKP2 [nucleoplasm] (Homo sapiens)
        
        SKP2 [nucleoplasm] (Homo sapiens)
        
        USP13:UFD1L:SKP2 [nucleoplasm] (Homo sapiens)
        
        UFD1L:SKP2 [nucleoplasm] (Homo sapiens)
        
        SKP2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13309 SKP2

Gene Names

SKP2, FBXL1

Chain

chain:1-424

Reference Genes

COSMIC (genes):SKP2 SKP2

dbSNP Gene:6502 SKP2

ENSEMBL:ENSG00000145604 SKP2

Participates

as a component of

as an input of

Other forms of this molecule

PolyUb-SKP2 [nucleoplasm]

SKP2 [cytosol]

Inferred To

Skp2 [nucleoplasm] (Drosophila melanogaster)

Skp2 [nucleoplasm] (Mus musculus)

Skp2 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of SKP2 [nucleoplasm] (Canis familiaris)

Ghost homologue of SKP2 [nucleoplasm] (Danio rerio)

Ghost homologue of SKP2 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of SKP2 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of SKP2 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of SKP2 [nucleoplasm] (Xenopus tropicalis)

SKP2 [nucleoplasm] (Bos taurus)

SKP2 [nucleoplasm] (Gallus gallus)

SKP2 [nucleoplasm] (Sus scrofa)

skpt-1 [nucleoplasm] (Caenorhabditis elegans)

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.952	18
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.892	12
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.858	9
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.823	15
UniProt:P46527 CDKN1B	8	p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.75	4
UniProt:P38936 CDKN1A	5	p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.731	4
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.725	6
UniProt:P20248 CCNA2	3	CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.725	6
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.725	7
UniProt:Q00526 CDK3			0.643	4
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.623	4
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.623	4
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.591	3
UniProt:Q9NTG7 SIRT3	2	SIRT3(?-399) [mitochondrial matrix] (R-HSA-1605416) SIRT3 [nucleoplasm] (R-HSA-9622879)	0.576	5
UniProt:P28562 DUSP1	1	DUSP1 [nucleoplasm] (R-HSA-203796)	0.576	3
UniProt:Q9UM11 FZR1	4	FZR1 [cytosol] (R-HSA-174249) FZR1 [nucleoplasm] (R-HSA-174099) p-FZR1 [nucleoplasm] (R-HSA-174257) p-FZR1 [cytosol] (R-HSA-174193)	0.564	4
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.527	3
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.527	2
UniProt:Q9H211 CDT1	1	CDT1 [nucleoplasm] (R-HSA-68536)	0.527	2
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	2
UniProt:Q13188 STK3	4	STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) STK3(323-491) [cytosol] (R-HSA-2028684) p-T180-STK3(1-322) [cytosol] (R-HSA-2028696)	0.527	2
UniProt:Q6SPF0 SAMD1			0.527	3
UniProt:Q6PJI9 WDR59	1	WDR59 [lysosomal membrane] (R-HSA-9638236)	0.527	3
UniProt:Q9BV68 RNF126	1	RNF126 [cytosol] (R-HSA-8851642)	0.527	2
UniProt:Q8N5M4 TTC9C			0.527	4
UniProt:Q6ZRV2 FA83H			0.527	3
UniProt:Q9BZL6 PRKD2	1	PRKD2 [cytosol] (R-HSA-58214)	0.527	2
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.527	3
UniProt:Q96BY7 ATG2B			0.527	2
UniProt:O14531 DPYSL4	3	p-S544-DPYSL4 [cytosol] (R-HSA-399808) p-Y-DPYSL4 [cytosol] (R-HSA-399794) DPYSL4 [cytosol] (R-HSA-398126)	0.527	2
UniProt:P0CI25 TRI49			0.527	2
UniProt:Q9H1A4 ANAPC1	2	ANAPC1 [cytosol] (R-HSA-174189) ANAPC1 [nucleoplasm] (R-HSA-174217)	0.527	3
UniProt:Q5VUJ6 LRCH2			0.527	2
UniProt:Q2VPB7 AP5B1			0.527	3
UniProt:Q9Y2Z0 SUGT1	1	SUGT1 [cytosol] (R-HSA-874107)	0.527	3
UniProt:P31321 PRKAR1B	2	PRKAR1B [cytosol] (R-HSA-57838) PRKAR1B [ciliary base] (R-HSA-5610409)	0.527	2
UniProt:Q9H9A6 LRC40			0.527	3
UniProt:P12268 IMPDH2	4	IMPDH2 [secretory granule lumen] (R-HSA-6803323) IMPDH2 [extracellular region] (R-HSA-6806455) IMPDH2 [ficolin-1-rich granule lumen] (R-HSA-6803330) IMPDH2 [cytosol] (R-HSA-57350)	0.527	2
UniProt:Q9UBW8 COPS7A	2	COPS7A [nucleoplasm] (R-HSA-5697011) COPS7A [cytosol] (R-HSA-416964)	0.527	2
UniProt:Q6DN90 IQEC1			0.527	3
UniProt:Q4AE16 Q4AE16			0.524	3
UniProt:Q13415 ORC1	5	ORC1 [nucleoplasm] (R-HSA-68522) ORC1 [cytosol] (R-HSA-113840) p-S,T-ORC1 [nucleoplasm] (R-HSA-68943) PolyUb,p-S,T-ORC1 [nucleoplasm] (R-HSA-9032189) PolyUb,p-S,T-ORC1 [cytosol] (R-HSA-9032195)	0.524	2
UniProt:P09803 Cdh1	6	CDH1(155-700) [plasma membrane] (R-MMU-2534244) CDH1(701-882) [extracellular region] (R-MMU-2534158) Cdh1(157-884) [plasma membrane] (R-MMU-199081) CDH1(155-750) [plasma membrane] (R-MMU-202940) CDH1(751-882) [plasma membrane] (R-MMU-202929) CDH1(155-882) [plasma membrane] (R-MMU-198003)	0.524	2
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.524	3

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