Reactome | N-Glycan antennae elongation

N-Glycan antennae elongation

Stable Identifier

R-HSA-975577

Type

Pathway

Species

Homo sapiens

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N-glycans are further modified after the commitment to Complex or Hybrid N-glycans. The exact structure of the network of metabolic reactions involved is complex and not yet validated experimentally. Here we will show a generic reaction for each of the genes known to be involved in N-Glycosylation.
For a better annotation of the reactions and genes involved in the synthesis of Complex and Hybrid N-glycans we recommend the GlycoGene Database (Ito H. et al, 2010) (http://riodb.ibase.aist.go.jp/rcmg/ggdb/textsearch.jsp) for annotations of genes, and the Consortium for Functional Genomics (http://riodb.ibase.aist.go.jp/rcmg/ggdb/textsearch.jsp) for annotation of Glycan structures and reactions. Moreover, a computationally inferred prediction for the structure of this network is available through the software GlycoVis (Hossler P. et. al. 2006).

Literature References

PubMed ID	Title	Journal	Year
20816477	In vitro and in vivo enzymatic syntheses and mass spectrometric database for N-glycans and o-glycans Ito, H, Chiba, Y, Kameyama, A, Sato, T, Narimatsu, H	Methods Enzymol	2010
16807922	GlycoVis: visualizing glycan distribution in the protein N-glycosylation pathway in mammalian cells Hossler, P, Goh, LT, Lee, MM, Hu, WS	Biotechnol Bioeng	2006