N-Glycan antennae elongation

Stable Identifier
R-HSA-975577
Type
Pathway
Species
Homo sapiens
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N-glycans are further modified after the commitment to Complex or Hybrid N-glycans. The exact structure of the network of metabolic reactions involved is complex and not yet validated experimentally. Here we will show a generic reaction for each of the genes known to be involved in N-Glycosylation.
For a better annotation of the reactions and genes involved in the synthesis of Complex and Hybrid N-glycans we recommend the GlycoGene Database (Ito H. et al, 2010) (http://riodb.ibase.aist.go.jp/rcmg/ggdb/textsearch.jsp) for annotations of genes, and the Consortium for Functional Genomics (http://riodb.ibase.aist.go.jp/rcmg/ggdb/textsearch.jsp) for annotation of Glycan structures and reactions. Moreover, a computationally inferred prediction for the structure of this network is available through the software GlycoVis (Hossler P. et. al. 2006).

Literature References
PubMed ID Title Journal Year
20816477 In vitro and in vivo enzymatic syntheses and mass spectrometric database for N-glycans and o-glycans

Ito, H, Chiba, Y, Kameyama, A, Sato, T, Narimatsu, H

Methods Enzymol 2010
16807922 GlycoVis: visualizing glycan distribution in the protein N-glycosylation pathway in mammalian cells

Hossler, P, Goh, LT, Lee, MM, Hu, WS

Biotechnol Bioeng 2006
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