PNLIP:CLPS hydrolyses RPALM to atROL and PALM

Stable Identifier
R-HSA-975593
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Digestion of retinyl palmitate by extracellular PTL:colipase
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Part of nutritional vitamin A is in the form of retinyl esters (REs). The main fatty acids which can form esters with retinol are palmitate, oleate, stearate and linoleate. REs are digested together with other lipids, and by the same enzymes. Pancreatic lipase catalyses the hydrolysis of RE to all-trans-retinol (atROL) and fatty acid which are then both taken up by enterocytic cell membranes (Bennekum et al. 2000).

Literature References
PubMed ID Title Journal Year
10769148 Hydrolysis of retinyl esters by pancreatic triglyceride lipase

van Bennekum, AM, Fisher, EA, Blaner, WS, Harrison, EH

Biochemistry 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
retinyl-palmitate esterase activity of PNLIP:CLPS [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created