Retinoid metabolism and transport

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R-HSA-975634
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Pathway
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Homo sapiens
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Vitamin A (all-trans-retinol) must be taken up, either as carotenes from plants, or as retinyl esters from animal food. The most prominent carotenes are alpha-carotene, lycopene, lutein, beta-cryptoxanthine, and especially beta-carotene. After uptake they are mostly broken down to retinal. Retinyl esters are hydrolysed like other fats. In enterocytes, retinoids bind to retinol-binding protein (RBP). Transport from enterocytes to the liver happens via chylomicrons (Harrison & Hussain 2001, Harrison 2005).

Literature References
PubMed ID Title Journal Year
11340090 Mechanisms involved in the intestinal digestion and absorption of dietary vitamin A

Harrison, EH, Hussain, MM

J Nutr 2001
16011460 Mechanisms of digestion and absorption of dietary vitamin A

Harrison, EH

Annu Rev Nutr 2005
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