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MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
Stable Identifier
R-HSA-9757255
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Activation of claspin (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Loading of claspin onto DNA during replication origin firing (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex. (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Mcm2-7 is phosphorylated by DDK (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
p-MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Unwinding of DNA (Homo sapiens)
MCM2-7 mediated fork unwinding (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Multiple proteins are localized at replication fork (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Unwinding complex at replication fork [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex. (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Mcm2-7 is phosphorylated by DDK (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
p-MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
CDT1 binds MCM2-7 (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin or replication:MCM2-7 double hexamer [nucleoplasm] (Homo sapiens)
MCM2-7 double hexamer [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Formation of MCM2-7 complex (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Unwinding of DNA (Homo sapiens)
MCM2-7 mediated fork unwinding (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Multiple proteins are localized at replication fork (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Unwinding complex at replication fork [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Participants
components
MCM2 [nucleoplasm]
(Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm]
(Homo sapiens)
Participates
as an output of
MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Homo sapiens)
as an input of
Formation of MCM2-7 complex (Homo sapiens)
as a component of
MCM2-7 [nucleoplasm] (Homo sapiens)
Inferred To
MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
(Bos taurus)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
(Caenorhabditis elegans)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
(Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
(Danio rerio)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
(Dictyostelium discoideum)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
(Drosophila melanogaster)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
(Gallus gallus)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
(Mus musculus)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
(Plasmodium falciparum)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
(Rattus norvegicus)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
(Saccharomyces cerevisiae)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
(Schizosaccharomyces pombe)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
(Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm]
(Xenopus tropicalis)
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