Reactome | MCM2 binds MCM4:MCM6:MCM7 heterotrimer

MCM2 binds MCM4:MCM6:MCM7 heterotrimer

Stable Identifier

R-HSA-9757258

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MCM2 binds to the complex of MCM4, MCM6 and MCM7 and inhibits its DNA helicase activity (Sato et al. 2000). Association of the complex of MCM4, MCM6 and MCM7 with the complex of MCM3 and MCM5 inhibits the DNA helicase activity (Sato et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10884341	Electron microscopic observation and single-stranded DNA binding activity of the Mcm4,6,7 complex. Ishimi, Y, Gotow, T, Komamura-Kohno, Y, You, Z, Sato, M, Nojima, H, Uchiyama, Y, Yabuta, N	J Mol Biol	2000