Reactome | Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation

Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation

Stable Identifier

R-HSA-9758090

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation

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The complex of VCP/p97 with cofactors UFD1, NPLOC4 and UBXN7 extract ubiquitinated NFE2L2 from the KEAP1-CUL3 ubiquitin ligase complex prior to its 26S proteasome-mediated degradation (Tao et al, 2017; Di Gregorio et al, 2021; reviewed in van den Boom and Meyer, 2020).

Literature References

PubMed ID	Title	Journal	Year
29153394	VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling van den Boom, J, Meyer, H	Mol Cell	2018
33444648	UBXN7 cofactor of CRL3^KEAP1 and CRL2^VHL ubiquitin ligase complexes mediates reciprocal regulation of NRF2 and HIF-1α proteins Di Gregorio, J, Zervos, AS, Liao, R, Andl, T, Ambivero, CT, Cilenti, L	Biochim Biophys Acta Mol Cell Res	2021
28115426	p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex Rojo de la Vega, M, Chen, H, Zhang, DD, Luo, G, Tao, S, Chapman, E, Wu, T, Tillotson, J, Liu, P	Mol Cell Biol	2017