Trimming of mannoses on the alpha1,6 arm by MAN2A1

Stable Identifier
R-HSA-975814
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The removal of mannoses on the alpha,1,6 arm by MAN2A1 or MAN2A2 is required for efficient formation of complex-type N-glycans (Misago M et al, 1995; Crispin M et al, 2007). These two enzymes carry out the same function and the disruption of both inhibits the formation of complex N-glycans in vivo (Akama TO et al, 2006).

Literature References
PubMed ID Title Journal Year
8524845 Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme

Misago, M, Liao, YF, Kudo, S, Eto, S, Mattéi, MG, Moremen, KW, Fukuda, MN

Proc Natl Acad Sci U S A 1995
16754854 Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice

Akama, TO, Nakagawa, H, Wong, NK, Sutton-Smith, M, Dell, A, Morris, HR, Nakayama, J, Nishimura, S, Pai, A, Moremen, KW, Marth, JD, Fukuda, MN

Proc Natl Acad Sci U S A 2006
17466984 Disruption of alpha-mannosidase processing induces non-canonical hybrid-type glycosylation

Crispin, M, Aricescu, AR, Chang, VT, Jones, EY, Stuart, DI, Dwek, RA, Davis, SJ, Harvey, DJ

FEBS Lett 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity of MAN2:Zn2+ [Golgi membrane]
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Activity
Orthologous Events
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