Reactome | Addition of a GlcNAc on the alpha 1,4 branch by MGAT2

Addition of a GlcNAc on the alpha 1,4 branch by MGAT2

Stable Identifier

R-HSA-975829

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        Reactions specific to the complex N-glycan synthesis pathway (Homo sapiens)
        
        Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Addition of a GlcNAc on the alpha 1,4 branch by MGAT2

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The addition of a GlcNAc on the alpha-1,6 mannose on the alpha-1,4 branch is required for the synthesis of complex N-glycans (Tan et al. 1995). Defects in this gene are associated with Congenital Disorder of Glycosylation type IIa (Tan et al. 1996, Wang et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12417412	Mice with a homozygous deletion of the Mgat2 gene encoding UDP-N-acetylglucosamine:alpha-6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II: a model for congenital disorder of glycosylation type IIa Marth, JD, Wang, Y, Schachter, H	Biochim Biophys Acta	2002
8808595	Mutations in the MGAT2 gene controlling complex N-glycan synthesis cause carbohydrate-deficient glycoprotein syndrome type II, an autosomal recessive disease with defective brain development Schachter, H, Dunn, J, Tan, J, Jaeken, J	Am J Hum Genet	1996
7635144	The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein Leong, P, Squire, JA, D'Agostaro, AF, Schachter, H, Sarkar, M, Tan, J, Bendiak, B, Reck, F	Eur J Biochem	1995