Reactome | Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex

Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex

Stable Identifier

R-HSA-975861

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Escherichia coli

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex

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IRAK4 deficient macrophages fail to induce IRAK2 phosphorylation (Kawagoe et al. 2008), suggesting that activated IRAK4 phosphorylates IRAK2 as it does IRAK1.

Phosphorylation sites of IRAK2 remain to be characterized.

Literature References

PubMed ID	Title	Journal	Year
18438411	Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 Kumagai, Y, Kawai, T, Takeuchi, O, Saitoh, T, Matsushita, K, Sato, S, Akira, S, Matsui, K, Kato, H, Kawagoe, T	Nat Immunol	2008