Reactome | SQSTM1 oligomerizes

SQSTM1 oligomerizes

Stable Identifier

R-HSA-9759158

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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SQSTM1 oligomerizes by virtue of its PB1 domain. Oligomerization is required for formation of inclusion bodies with ubiquitinated proteins destined for autophagic degradation, and may contribute to phagophore membrane development (Bjorkoy et al, 2005; Ciuffa et al, 2015; Itakura and Mizushima, 2011; reviewed in Lamark et al, 2017).

Literature References

PubMed ID	Title	Journal	Year
21220506	p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding Itakura, E, Mizushima, N	J Cell Biol	2011
29233872	Regulation of selective autophagy: the p62/SQSTM1 paradigm Svenning, S, Lamark, T, Johansen, T	Essays Biochem	2017
25921531	The selective autophagy receptor p62 forms a flexible filamentous helical scaffold Ciuffa, R, Guesdon, A, Sachse, C, Rybina, S, Lamark, T, Johansen, T, Tarafder, AK, Hagen, WJ	Cell Rep	2015
16286508	p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death Lamark, T, Overvatn, A, Brech, A, Johansen, T, Perander, M, Bjørkøy, G, Stenmark, H, Outzen, H	J Cell Biol	2005