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Nuclear events mediated by NFE2L2
Stable Identifier
R-HSA-9759194
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
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In response to chemical and other stressors, the constitutive degradation of NFE2L2 by the KEAP1:CUL3:26S proteasome system is disrupted, allowing NFE2L2 to accumulate. Stabilized NFE2L2 translocates to the nucleus where it binds to antioxidant response elements (AREs) in the promoters and enhancers of target genes to upregulate their expression (reviewed in Baird and Yamamoto, 2020).
Literature References
PubMed ID
Title
Journal
Year
32284348
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
Yamamoto, M
,
Baird, L
Mol Cell Biol
2020
Participants
Events
Regulation of NFE2L2 gene expression
(Homo sapiens)
AcK-NFE2L2 binds the KEAP1 gene
(Homo sapiens)
NFE2L2 dependent KEAP1 expression
(Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
(Homo sapiens)
NFE2L2 binds CREBBP,EP300
(Homo sapiens)
CREBBP, EP300 acetylates NFE2L2
(Homo sapiens)
p14ARF binds NFE2L2:CREBBP, EP300
(Homo sapiens)
NFE2L2 and MAFG bind the SQSTM1 gene
(Homo sapiens)
NFE2L2-dependent SQSTM1 gene expression
(Homo sapiens)
PRKAA2 phosphorylates nuclear NFE2L2
(Homo sapiens)
PRKAA2 regulated nuclear export of NFE2L2
(Homo sapiens)
NFE2L2 regulating ER-stress associated genes
(Homo sapiens)
NFE2L2 regulating MDR associated enzymes
(Homo sapiens)
NFE2L2 regulating TCA cycle genes
(Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes
(Homo sapiens)
NFE2L2 regulating inflammation associated genes
(Homo sapiens)
NFE2L2 regulates pentose phosphate pathway genes
(Homo sapiens)
NFE2L2 regulating tumorigenic genes
(Homo sapiens)
Participates
as an event of
KEAP1-NFE2L2 pathway (Homo sapiens)
Orthologous Events
Nuclear events mediated by NFE2L2 (Bos taurus)
Nuclear events mediated by NFE2L2 (Caenorhabditis elegans)
Nuclear events mediated by NFE2L2 (Canis familiaris)
Nuclear events mediated by NFE2L2 (Danio rerio)
Nuclear events mediated by NFE2L2 (Dictyostelium discoideum)
Nuclear events mediated by NFE2L2 (Drosophila melanogaster)
Nuclear events mediated by NFE2L2 (Gallus gallus)
Nuclear events mediated by NFE2L2 (Mus musculus)
Nuclear events mediated by NFE2L2 (Rattus norvegicus)
Nuclear events mediated by NFE2L2 (Saccharomyces cerevisiae)
Nuclear events mediated by NFE2L2 (Schizosaccharomyces pombe)
Nuclear events mediated by NFE2L2 (Sus scrofa)
Nuclear events mediated by NFE2L2 (Xenopus tropicalis)
Authored
Rothfels, K (2021-10-08)
Reviewed
Cuadrado, A (2022-02-23)
Created
Rothfels, K (2021-11-29)
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