The canonical isoform of human CDH11, but not the variant isoform, is cleaved to produce an 80 kDa secreted fragment (Kawaguchi et al 1999). The exact cleavage site is not known but based on the size of the secreted fragment is predicted to occur close to the boundary of ectodomains EC3 and EC4. In Xenopus laevis, the orthologues cleavage, which occurs during the migration of cranial neural crest cells, can be performed by either ADAM13 or ADAM9 metalloproteinases, but not ADAM19 (McCusker et al. 2009). The cleavage of Xenopus cadherin-11 by ADAM13 appears to be biologically relevant (Abbruzzese et al. 2014). The closest human orthologues of Xenopus ADAM13 are ADAM19 and ADAM33, which are annotated as candidate metalloproteinases.