Reactome | Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin

Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin

Stable Identifier

R-HSA-9759549

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol

Synonyms

2 cob(I)alamin + H(+) + NAD(+) => 2 cob(II)alamin + NADH

ReviewStatus

5/5

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Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin

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Cob(I)alamin bound to MMACHC (Methylmalonic aciduria and homocystinuria type C protein, aka cblC protein) is oxidized to cob(II)alamin. Possible mechanisms for this conversion have been described (Banerjee et al. 2021). The reaction is annotated here with an unknown enzyme catalyst; its chemistry is inferred from that of the bacterial system described by Walker et al. (1969).

Literature References

PubMed ID	Title	Journal	Year
33797888	Redox-Linked Coordination Chemistry Directs Vitamin B₁₂ Trafficking Gouda, H, Pillay, S, Banerjee, R	Acc Chem Res	2021
4390543	Enzymatic conversion of vitamin B 12a to adenosyl-B 12: evidence for the existence of two separate reducing systems Walker, GA, Murphy, S, Huennekens, FM	Arch Biochem Biophys	1969