Regulation of CDH11 mRNA translation by microRNAs

Stable Identifier
R-HSA-9759811
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Regulation of CDH11 mRNA translation by microRNAs
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Several microRNAs are implicated in posttranscriptional regulation of CDH11 gene expression. The diagram only shows microRNAs reported to downregulate CDH11 mRNA and/or protein levels by at least 2 studies, with at least one study providing human evidence, and at least one study providing mechanistic evidence in the form of luciferase reporter assay and/or formation of the microRNA-mRNA complex. For a more detailed description of criteria for microRNA annotation please refer to Huntely et al. 2016.

The following CDH11-targeting microRNAs are strongly supported by experimental evidence and directly shown in the diagram:
miR-200c-3p (Luo et al. 2013; Van der Goten et al. 2014)
miR-451a (Yamada et al. 2018; Wang et al. 2020; Wang et al. 2021)

The following microRNAs probably target CDH11, but additional evidence is needed to directly represent them in the diagram:
miR-103-2-5p (Gao et al. 2020)
miR-127-3p (Dong et al. 2021)
miR-148-5p (Kawagoe et al. 2020)
Literature References
PubMed ID Title Journal Year
33271553 Downregulation of miRNA-451a Promotes the Differentiation of CD4+ T Cells towards Th2 Cells by Upregulating ETS1 in Childhood Asthma

Shang, Y, Zhou, Q, Wang, T

J Innate Immun 2021
32235846 Regulation of aberrantly expressed SERPINH1 by antitumor miR-148a-5p inhibits cancer cell aggressiveness in gastric cancer

Seki, N, Kawagoe, K, Matsushita, D, Wada, M, Natsugoe, S, Idichi, T, Kurahara, H, Okubo, K, Yamada, Y, Okada, R, Maemura, K, Arigami, T, Moriya, S

J Hum Genet 2020
32572925 Tumor-derived exosomal miR-103a-2-5p facilitates esophageal squamous cell carcinoma cell proliferation and migration

Zhou, D, Hou, B, Lu, X, Zhang, K, Dai, JG, Zhang, J, Zheng, H, Liu, QX, Gao, DC

Eur Rev Med Pharmacol Sci 2020
23497265 A systematic evaluation of miRNA:mRNA interactions involved in the migration and invasion of breast cancer cells

Liu, J, Huang, S, Wilson, JM, Pei, L, Hawthorn, L, Harvel, N, Luo, D, Shi, H

J Transl Med 2013
32234673 MiRNA-451a inhibits airway remodeling by targeting Cadherin 11 in an allergic asthma model of neonatal mice

Shang, Y, Zhou, Q, Wang, T

Int Immunopharmacol 2020
33574696 Exosome-Encapsulated microRNA-127-3p Released from Bone Marrow-Derived Mesenchymal Stem Cells Alleviates Osteoarthritis Through Regulating CDH11-Mediated Wnt/β-Catenin Pathway

Fang, X, Zang, M, Li, L, Dong, J

J Pain Res 2021
29417701 Impact of novel oncogenic pathways regulated by antitumor miR-451a in renal cell carcinoma

Ichikawa, T, Seki, N, Naya, Y, Yamada, Y, Yamazaki, K, Arai, T, Okato, A, Kojima, S, Sugawara, S, Kato, M

Cancer Sci 2018
25546151 Integrated miRNA and mRNA expression profiling in inflamed colon of patients with ulcerative colitis

Van Assche, G, Rutgeerts, P, Wollants, WJ, Vermeire, S, Schuit, F, Ferrante, M, Lemaire, K, Van der Goten, J, Arijs, I, de Hertogh, G, Vanhove, W, Van Lommel, L, Machiels, K, De Preter, V

PLoS One 2014
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miRNA-mediated post-transcriptional gene silencing (0035195)
Authored
Orlic-Milacic, M  (2022-06-02)
Reviewed
Brasch, J  (2023-04-18)
Created
Orlic-Milacic, M  (2021-12-13)
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