Reactome | ARIH2 [cytosol]

ARIH2 [cytosol]

Stable Identifier

R-HSA-975987

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase ARIH2, ARI2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O95376 ARIH2

Gene Names

ARIH2, ARI2, TRIAD1, HT005

Chain

chain:1-493

Reference Genes

BioGPS Gene:10425 ARIH2

COSMIC (genes):ARIH2 ARIH2

CTD Gene:10425 ARIH2

dbSNP Gene:10425 ARIH2

ENSEMBL:ENSG00000177479 ARIH2

ENSEMBL_homo_sapiens_GENE:ENSG00000177479.20 ARIH2

HGNC:690 ARIH2

KEGG Gene (Homo sapiens):10425 ARIH2

Monarch:10425 ARIH2

NCBI Gene:10425 ARIH2

OMIM:605615 ARIH2

Reference Transcript

Other Identifiers

10425

11717394_at

11717395_a_at

11754979_x_at

16940557

201228_PM_s_at

201228_s_at

201229_PM_s_at

201229_s_at

201230_PM_s_at

201230_s_at

216008_PM_s_at

216008_s_at

2621828

2621831

2621832

2621836

2621837

2621846

2621847

2621848

2621850

2621851

2621855

2621858

2621862

2621864

2621866

2621868

2621869

2621872

2621873

2621874

2621875

2621876

2621877

3783118

3783119

3783123

39164_at

8079662

A_23_P61881

A_24_P94651

GE61552

GO:0000151

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006511

GO:0006886

GO:0007005

GO:0008270

GO:0016567

GO:0016740

GO:0019538

GO:0030154

GO:0030163

GO:0031466

GO:0031624

GO:0032436

GO:0036211

GO:0043226

GO:0046872

GO:0048588

GO:0048856

GO:0061630

GO:0070534

GO:0070936

GO:0071425

GO:0140096

GO:1903955

HMNXSV003046972

HMNXSV003056238

Hs.241558.2.S1_3p_a_at

ILMN_1792825

PH_hs_0012955

TC03002330.hg

g12653306_3p_a_at

g5453556_3p_a_at

Participates

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

ARIH2 [cytosol] (Bos taurus)

ARIH2 [cytosol] (Caenorhabditis elegans)

ARIH2 [cytosol] (Dictyostelium discoideum)

ARIH2 [cytosol] (Drosophila melanogaster)

ARIH2 [cytosol] (Gallus gallus)

ARIH2 [cytosol] (Mus musculus)

ARIH2 [cytosol] (Plasmodium falciparum)

ARIH2 [cytosol] (Saccharomyces cerevisiae)

ARIH2 [cytosol] (Schizosaccharomyces pombe)

ARIH2 [cytosol] (Sus scrofa)

Arih2 [cytosol] (Rattus norvegicus)

Homologues of ARIH2 [cytosol] (Dictyostelium discoideum)

arih2 [cytosol] (Danio rerio)

arih2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001304263.1, XP_016861020.1, XP_016861021.1, NP_006312.1, NP_001304262.1

OpenTargets

ENSG00000177479

HPA

ENSG00000177479-ARIH2

GeneCards

O95376

Ensembl

ENSP00000348769, ENST00000449376, ENST00000356401, ENSP00000403222, ENSG00000177479

PRO

O95376

Pharos - Targets

O95376

PDB

7ONI, 7OD1

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P68036 UBE2L3	4	Ub-C86-UBE2L3 [nucleoplasm] (R-HSA-8864226) UBE2L3 [nucleoplasm] (R-HSA-8852056) UBE2L3 [cytosol] (R-HSA-947631) Ub-C86-UBE2L3 [cytosol] (R-HSA-8864201)	0.884	12
UniProt:O14933 UBE2L6	2	UBE2L6 [cytosol] (R-HSA-936014) UBE2L6 [nucleoplasm] (R-HSA-5653666)	0.879	14
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.691	5
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.677	13
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.623	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:P51813 BMX	3	BMX(1-242) [cytosol] (R-HSA-351899) BMX [cytosol] (R-HSA-351917) BMX(243-675) [cytosol] (R-HSA-351875)	0.527	2
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.527	2
UniProt:Q9NPD8 UBE2T	3	Ub-C86-UBE2T [nucleoplasm] (R-HSA-8864217) UBE2T [nucleoplasm] (R-HSA-420942) MonoUb-K91,K182-UBE2T [nucleoplasm] (R-HSA-6785362)	0.488	2

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