Reactome | RNF5 [endoplasmic reticulum membrane]

RNF5 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-975990

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

E3 ubiquitin-protein ligase RNF5, RNF5_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99942 RNF5

Gene Names

RNF5, G16, NG2, RMA1

Chain

initiator methionine:1, chain:2-180

Reference Genes

BioGPS Gene:6048 RNF5

COSMIC (genes):RNF5 RNF5

CTD Gene:6048 RNF5

dbSNP Gene:6048 RNF5

ENSEMBL:ENSG00000183574 RNF5

ENSEMBL:ENSG00000204308 RNF5

ENSEMBL:ENSG00000223767 RNF5

ENSEMBL:ENSG00000225452 RNF5

ENSEMBL:ENSG00000227277 RNF5

ENSEMBL:ENSG00000228405 RNF5

ENSEMBL:ENSG00000228907 RNF5

HGNC:10068 RNF5

KEGG Gene (Homo sapiens):6048 RNF5

Monarch:6048 RNF5

NCBI Gene:6048 RNF5

OMIM:602677 RNF5

UCSC:Q99942 RNF5

Reference Transcript

RefSeq:NM_006913.3 RNF5

Other Identifiers

0001410168

11757623_s_at

17007237

17026393

17028297

17033588

17035866

17038580

17041209

209111_at

2903131

2903132

2903133

2903135

2903137

2903139

2903140

2903141

3132181

3132182

3132183

3132184

3132186

3132187

3132188

3132189

3132191

3132192

3132193

3132194

33347_at

6048

8118535

8150356

8178188

8179472

A_23_P320200

A_23_P8095

A_32_P185149

GE62145

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005783

GO:0005789

GO:0006464

GO:0006511

GO:0006810

GO:0006914

GO:0006950

GO:0008150

GO:0008270

GO:0009056

GO:0009617

GO:0010507

GO:0016020

GO:0016021

GO:0016567

GO:0016740

GO:0019899

GO:0022607

GO:0030433

GO:0031648

GO:0031966

GO:0036503

GO:0042802

GO:0043167

GO:0043226

GO:0044257

GO:0044322

GO:0044390

GO:0044877

GO:0046872

GO:0055085

GO:0061630

GO:0070534

GO:0070936

GO:0071712

GO:1904380

GO:2000785

ILMN_1674943

ILMN_2044927

PH_hs_0030665

PH_hs_0039561

TC06000395.hg

TC06002724.hg

TC08002294.hg

TC6_apd_hap1000044.hg

TC6_cox_hap2000087.hg

TC6_mann_hap4000071.hg

TC6_mcf_hap5000073.hg

TC6_qbl_hap6000078.hg

TC6_ssto_hap7000073.hg

U89336_cds4_at

g13278761_3p_at

Participant Of

hasMember

Inferred To

RNF5 [endoplasmic reticulum membrane] (Canis familiaris)

RNF5 [endoplasmic reticulum membrane] (Sus scrofa)

Rnf5 [endoplasmic reticulum membrane] (Mus musculus)

Rnf5 [endoplasmic reticulum membrane] (Rattus norvegicus)

rnf-5 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Dmel\CG8974 [endoplasmic reticulum membrane] (Drosophila melanogaster)

rnf5 [endoplasmic reticulum membrane] (Danio rerio)

rnf5 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_008844.1

OpenTargets

ENSG00000204308

IntEnz

2.3.2.27

HPA

ENSG00000204308-RNF5

GeneCards

Q99942

Ensembl

ENSG00000228405, ENSP00000401172, ENST00000445885, ENST00000453473, ENSP00000388795, ENST00000375094, ENST00000449794, ENST00000432616, ENSP00000413131, ENST00000456167, ENST00000413786, ENSG00000204308, ENSG00000223767, ENSP00000387879, ENSP00000415784, ENSP00000415127, ENSG00000228907, ENSG00000183574, ENSG00000227277, ENSG00000225452, ENSP00000364235

PRO

Q99942

HMDB Protein

HMDBP09302

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.591	6
UniProt:Q96QD8 SLC38A2	1	SLC38A2 [plasma membrane] (R-HSA-352093)	0.576	3
UniProt:Q15758 SLC1A5	1	SLC1A5 [plasma membrane] (R-HSA-352376)	0.576	4
UniProt:Q8IY26 PLPP6	1	PLPP6 [plasma membrane] (R-HSA-8952144)	0.556	3
UniProt:Q5VVQ6 YOD1	1	YOD1 [cytosol] (R-HSA-6781909)	0.556	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3
UniProt:Q96CV9 OPTN	4	OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525)	0.556	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.537	3