Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
RNF5 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-975990
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
E3 ubiquitin-protein ligase RNF5, RNF5_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
ABC transporter disorders (Homo sapiens)
Defective CFTR causes cystic fibrosis (Homo sapiens)
CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)
CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
RNF5,RNF185 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
RNF5,RNF185 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 and RNF185 ubiquitinate CFTR F508del (Homo sapiens)
CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
RNF5,RNF185 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
RNF5,RNF185 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
RNF5,RNF185 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
RNF5,RNF185 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Homo sapiens)
Calnexin/calreticulin cycle (Homo sapiens)
ER Quality Control Compartment (ERQC) (Homo sapiens)
OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5 (Homo sapiens)
ERAD E3 ligases [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
OS9:SEL1:ERAD E3 ligases:DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
ERAD E3 ligases [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
RNF5,RNF185 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
RNF5,RNF185 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Homo sapiens)
RNF5,RNF185 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
RNF5,RNF185 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
RNF5,RNF185 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
RNF5,RNF185 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
RNF5,RNF185 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99942 RNF5
Gene Names
RNF5, G16, NG2, RMA1
Chain
initiator methionine:1, chain:2-180
Reference Genes
BioGPS Gene:6048 RNF5
COSMIC (genes):RNF5 RNF5
CTD Gene:6048 RNF5
dbSNP Gene:6048 RNF5
ENSEMBL:ENSG00000183574 RNF5
ENSEMBL:ENSG00000204308 RNF5
ENSEMBL:ENSG00000223767 RNF5
ENSEMBL:ENSG00000225452 RNF5
ENSEMBL:ENSG00000227277 RNF5
ENSEMBL:ENSG00000228405 RNF5
ENSEMBL:ENSG00000228907 RNF5
HGNC:10068 RNF5
KEGG Gene (Homo sapiens):6048 RNF5
Monarch:6048 RNF5
NCBI Gene:6048 RNF5
OMIM:602677 RNF5
UCSC:Q99942 RNF5
Reference Transcript
RefSeq:NM_006913.3 RNF5
Other Identifiers
0001410168
11757623_s_at
17007237
17026393
17028297
17033588
17035866
17038580
17041209
209111_at
2903131
2903132
2903133
2903135
2903137
2903139
2903140
2903141
3132181
3132182
3132183
3132184
3132186
3132187
3132188
3132189
3132191
3132192
3132193
3132194
33347_at
6048
8118535
8150356
8178188
8179472
A_23_P320200
A_23_P8095
A_32_P185149
GE62145
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005783
GO:0005789
GO:0006464
GO:0006511
GO:0006810
GO:0006914
GO:0006950
GO:0008150
GO:0008270
GO:0009056
GO:0009617
GO:0010507
GO:0016020
GO:0016021
GO:0016567
GO:0016740
GO:0019899
GO:0022607
GO:0030433
GO:0031648
GO:0031966
GO:0036503
GO:0042802
GO:0043167
GO:0043226
GO:0044257
GO:0044322
GO:0044390
GO:0044877
GO:0046872
GO:0055085
GO:0061630
GO:0070534
GO:0070936
GO:0071712
GO:1904380
GO:2000785
ILMN_1674943
ILMN_2044927
PH_hs_0030665
PH_hs_0039561
TC06000395.hg
TC06002724.hg
TC08002294.hg
TC6_apd_hap1000044.hg
TC6_cox_hap2000087.hg
TC6_mann_hap4000071.hg
TC6_mcf_hap5000073.hg
TC6_qbl_hap6000078.hg
TC6_ssto_hap7000073.hg
U89336_cds4_at
g13278761_3p_at
Participant Of
hasMember
ERAD E3 ligases [endoplasmic reticulum membrane]
RNF5,RNF185 [endoplasmic reticulum membrane]
Inferred To
RNF5 [endoplasmic reticulum membrane] (Canis familiaris)
RNF5 [endoplasmic reticulum membrane] (Sus scrofa)
Rnf5 [endoplasmic reticulum membrane] (Mus musculus)
Rnf5 [endoplasmic reticulum membrane] (Rattus norvegicus)
rnf-5 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
Dmel\CG8974 [endoplasmic reticulum membrane] (Drosophila melanogaster)
rnf5 [endoplasmic reticulum membrane] (Danio rerio)
rnf5 [endoplasmic reticulum membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_008844.1
OpenTargets
ENSG00000204308
IntEnz
2.3.2.27
HPA
ENSG00000204308-RNF5
GeneCards
Q99942
Ensembl
ENSG00000228405
,
ENSP00000401172
,
ENST00000445885
,
ENST00000453473
,
ENSP00000388795
,
ENST00000375094
,
ENST00000449794
,
ENST00000432616
,
ENSP00000413131
,
ENST00000456167
,
ENST00000413786
,
ENSG00000204308
,
ENSG00000223767
,
ENSP00000387879
,
ENSP00000415784
,
ENSP00000415127
,
ENSG00000228907
,
ENSG00000183574
,
ENSG00000227277
,
ENSG00000225452
,
ENSP00000364235
PRO
Q99942
HMDB Protein
HMDBP09302
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49023 PXN
4
PXN [plasma membrane]
(R-HSA-180493)
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.591
6
UniProt:Q96QD8 SLC38A2
1
SLC38A2 [plasma membrane]
(R-HSA-352093)
0.576
3
UniProt:Q15758 SLC1A5
1
SLC1A5 [plasma membrane]
(R-HSA-352376)
0.576
4
UniProt:Q8IY26 PLPP6
1
PLPP6 [plasma membrane]
(R-HSA-8952144)
0.556
3
UniProt:Q5VVQ6 YOD1
1
YOD1 [cytosol]
(R-HSA-6781909)
0.556
3
UniProt:O00767 SCD
1
SCD [endoplasmic reticulum membrane]
(R-HSA-400117)
0.556
3
UniProt:Q96CV9 OPTN
4
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
0.556
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.537
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text