Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
RNF6 [cytosol]
Stable Identifier
R-HSA-975997
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase RNF6, RNF6_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF6 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF6 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF6 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF6 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF6 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF6 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF6 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF6 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF6 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y252 RNF6
Gene Names
RNF6, SPG2
Chain
chain:1-685
Reference Genes
BioGPS Gene:6049 RNF6
COSMIC (genes):RNF6 RNF6
CTD Gene:6049 RNF6
dbSNP Gene:6049 RNF6
ENSEMBL:ENSG00000127870 RNF6
ENSEMBL_homo_sapiens_GENE:ENSG00000127870.17 RNF6
HGNC:10069 RNF6
KEGG Gene (Homo sapiens):6049 RNF6
Monarch:6049 RNF6
NCBI Gene:6049 RNF6
OMIM:604242 RNF6
UCSC:Q9Y252 RNF6
Reference Transcript
RefSeq:NM_183044.2 RNF6
RefSeq:NM_183045.1 RNF6
RefSeq:NM_005977.3 RNF6
RefSeq:XM_011535177.2 RNF6
RefSeq:NM_183043.2 RNF6
RefSeq:XM_011535178.1 RNF6
RefSeq:XM_005266485.2 RNF6
RefSeq:XM_005266486.2 RNF6
Other Identifiers
11720198_s_at
11746183_a_at
11749977_a_at
16777579
203403_PM_s_at
203403_s_at
210932_PM_s_at
210932_s_at
3506455
3506456
3506457
3506458
3506459
3506460
3506461
3506462
3506463
3506464
3506466
3506467
3506469
3506470
3506471
3506472
3506473
3506474
35656_at
6049
7970681
A_23_P162734
A_24_P144881
GE55193
GO:0003677
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0006351
GO:0006355
GO:0006511
GO:0016567
GO:0016605
GO:0016740
GO:0023052
GO:0030154
GO:0030163
GO:0030424
GO:0030517
GO:0031965
GO:0036211
GO:0042995
GO:0043226
GO:0043231
GO:0044314
GO:0045893
GO:0046872
GO:0048675
GO:0048856
GO:0050681
GO:0060765
GO:0061630
GO:0070936
GO:0085020
GO:0140096
HMNXSV003004312
HMNXSV003042779
ILMN_1687431
ILMN_1725306
ILMN_2275455
PH_hs_0027852
PH_hs_0035215
TC13000502.hg
g5174652_3p_a_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
RNF6 [cytosol]
(Bos taurus)
RNF6 [cytosol]
(Canis familiaris)
RNF6 [cytosol]
(Dictyostelium discoideum)
RNF6 [cytosol]
(Gallus gallus)
RNF6 [cytosol]
(Plasmodium falciparum)
RNF6 [cytosol]
(Sus scrofa)
Rnf6 [cytosol]
(Mus musculus)
Rnf6 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_898864.1
,
XP_011533480.1
,
XP_005266542.1
,
NP_005968.1
,
NP_898866.1
,
XP_005266543.1
,
NP_898865.1
,
XP_011533479.1
OpenTargets
ENSG00000127870
GeneCards
Q9Y252
HPA
ENSG00000127870-RNF6
Ensembl
ENSP00000342121
,
ENST00000346166
,
ENSP00000370982
,
ENST00000381570
,
ENSP00000371000
,
ENST00000381588
,
ENSG00000127870
PRO
Q9Y252
Pharos - Targets
Q9Y252
Orphanet
25179
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.584
10
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text