Reactome | AMFR [endoplasmic reticulum membrane]

AMFR [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-975999

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

E3 ubiquitin-protein ligase AMFR, AMFR2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UKV5 AMFR

Gene Names

AMFR, RNF45

Chain

chain:1-643

Reference Genes

BioGPS Gene:267 AMFR

COSMIC (genes):AMFR AMFR

CTD Gene:267 AMFR

dbSNP Gene:267 AMFR

ENSEMBL:ENSG00000159461 AMFR

ENSEMBL_homo_sapiens_GENE:ENSG00000159461.15 AMFR

HGNC:463 AMFR

KEGG Gene (Homo sapiens):267 AMFR

Monarch:267 AMFR

NCBI Gene:267 AMFR

OMIM:603243 AMFR

UCSC:Q9UKV5 AMFR

Reference Transcript

Other Identifiers

11717261_a_at

11756087_a_at

16826692

202203_PM_s_at

202203_s_at

202204_PM_s_at

202204_s_at

267

3692857

3692858

3692859

3692860

3692861

3692862

3692863

3692864

3692866

3692870

3692871

3692876

3692877

3692878

3692879

3692881

3692883

3692884

3692885

3692886

3692892

3692893

3692894

38068_at

8001477

87138_at

A_23_P141005

A_24_P135444

GE58024

GO:0000151

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006511

GO:0007165

GO:0007611

GO:0016020

GO:0016055

GO:0016567

GO:0016740

GO:0023052

GO:0030163

GO:0030425

GO:0030426

GO:0030433

GO:0030674

GO:0030968

GO:0032092

GO:0032991

GO:0034450

GO:0036211

GO:0036513

GO:0038023

GO:0038061

GO:0042802

GO:0043025

GO:0043130

GO:0043226

GO:0044314

GO:0046872

GO:0048471

GO:0050877

GO:0051087

GO:0051865

GO:0060089

GO:0060090

GO:0061630

GO:0070936

GO:0090090

GO:0140096

GO:1904288

GO:1990381

GO:2000638

HMNXSV003008026

ILMN_1666258

ILMN_1723116

M63175_at

PH_hs_0023564

TC16001132.hg

g5931954_3p_a_at

Participates

as a component of

Deglycosylation complex [endoplasmic reticulum membrane] (Homo sapiens)

as a member of

ERAD E3 ligases [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

Ghost homologue of AMFR [endoplasmic reticulum membrane] (Drosophila melanogaster)

hrdl-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Amfr [endoplasmic reticulum membrane] (Mus musculus)

Amfr [endoplasmic reticulum membrane] (Rattus norvegicus)

amfr [endoplasmic reticulum membrane] (Danio rerio)

amfr [endoplasmic reticulum membrane] (Xenopus tropicalis)

AMFR [endoplasmic reticulum membrane] (Bos taurus)

AMFR [endoplasmic reticulum membrane] (Canis familiaris)

AMFR [endoplasmic reticulum membrane] (Gallus gallus)

AMFR [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_001135.3, NP_001310441.1

OpenTargets

ENSG00000159461

IntEnz

2.3.2.36

GeneCards

Q9UKV5

HPA

ENSG00000159461-AMFR

Ensembl

ENST00000290649, ENSP00000290649, ENSG00000159461

PRO

Q9UKV5

Pharos - Targets

Q9UKV5

HMDB Protein

HMDBP09276

PDB

2EJS, 2LXP, 3H8K, 3TIW, 3FSH, 2LXH, 2LVP, 4G3O, 2LVO, 4LAD, 2LVN, 2LVQ

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.874	12
UniProt:P51668 UBE2D1	3	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160)	0.553	2
UniProt:P61077 UBE2D3	3	Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191) UBE2D3 [cytosol] (R-HSA-934630) UBE2D3 [nucleoplasm] (R-HSA-205341)	0.553	2
UniProt:P61088 UBE2N	5	Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013) Ub-C87-UBE2N [cytosol] (R-HSA-8864210) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) UBE2N [nucleoplasm] (R-HSA-5682541) UBE2N [cytosol] (R-HSA-206072)	0.553	2