Reactome | p-S40-18 AcK-NFE2L2 [nucleoplasm]

p-S40-18 AcK-NFE2L2 [nucleoplasm]

Stable Identifier

R-HSA-9760018

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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External Reference Information

External Reference

UniProt:Q16236 NFE2L2

Gene Names

NFE2L2, NRF2

Chain

chain:1-605

Reference Genes

BioGPS Gene:4780 NFE2L2

COSMIC (genes):NFE2L2 NFE2L2

CTD Gene:4780 NFE2L2

dbSNP Gene:4780 NFE2L2

ENSEMBL:ENSG00000116044 NFE2L2

HGNC:7782 NFE2L2

KEGG:hsa:4780 NFE2L2

Monarch:4780 NFE2L2

NCBI Gene:4780 NFE2L2

OMIM:600492 NFE2L2

UCSC:Q16236 NFE2L2

Reference Transcript

Other Identifiers

11739057_a_at

11743380_s_at

1567013_PM_at

1567013_at

16905475

201146_PM_at

201146_at

207688_PM_s_at

207688_s_at

2588820

2588822

2588824

2588825

2588826

2588828

2588829

2588831

2588832

2588833

2588834

2588835

2588836

2588837

2588838

2588839

2588840

2588841

2588842

2588843

2588844

2588845

2588846

2588847

2588863

2588864

2588865

2588866

2588867

2588868

2588870

2588871

2588890

2588896

2588905

2588906

2588908

2588909

2588910

2588913

2588915

2588916

2588924

2654549

4024236

4780

8056977

82873_at

853_at

91941_at

A_19_P00315584

A_19_P00319717

A_23_P5761

A_24_P400172

A_32_P134772

A_33_P3225600

GE81603

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001221

GO:0001228

GO:0002931

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005886

GO:0006355

GO:0006357

GO:0006954

GO:0006979

GO:0009410

GO:0010468

GO:0010499

GO:0010628

GO:0010667

GO:0010976

GO:0016567

GO:0016592

GO:0019904

GO:0030163

GO:0030194

GO:0030968

GO:0031625

GO:0032993

GO:0034599

GO:0034976

GO:0036499

GO:0042149

GO:0043161

GO:0043226

GO:0043536

GO:0043565

GO:0045088

GO:0045454

GO:0045766

GO:0045893

GO:0045944

GO:0045995

GO:0046223

GO:0046326

GO:0060090

GO:0061431

GO:0061629

GO:0070301

GO:0071280

GO:0071356

GO:0071456

GO:0071466

GO:0071498

GO:0071499

GO:0080090

GO:0090575

GO:0098754

GO:0110076

GO:0140110

GO:0140467

GO:0140693

GO:1900038

GO:1900407

GO:1902037

GO:1902176

GO:1903788

GO:1904294

GO:1904385

GO:1904753

GO:2000060

GO:2000121

GO:2000352

GO:2000379

HMNXSV003047979

ILMN_1696318

ILMN_1790909

PH_hs_0009358

S74017_at

TC02004721.hg

TC02005045.hg

TC03002972.hg

g5031794_3p_at

g5453775_3p_at

p26100

p9452

Participates

as a candidate of

p-AcK-NFE2L2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-S40-NFE2L2 [nucleoplasm]

p-S,T-NFE2L2 [nucleoplasm]

p-S40-NFE2L2 [cytosol]

p-S,T-NFE2L2 [cytosol]

NFE2L2 [cytosol]

p-S,T-18 AcK-NFE2L2 [nucleoplasm]

ub-NFE2L2 [cytosol]

ub-p-S335, S338,T-NFE2L2 [nucleoplasm]

ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]

p-S344, S347,T-NFE2L2 [nucleoplasm]

p-S40, S344, S347- NFE2L2 [nucleoplasm]

p-S,T,S558-NFE2L2 [nucleoplasm]

Inferred To

phospho-skn-1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of p-S40-18 AcK-NFE2L2 [nucleoplasm] (Caenorhabditis elegans)

phospho-nfe2l2 [nucleoplasm] (Xenopus tropicalis)

phospho-NFE2L2 [nucleoplasm] (Bos taurus)

phospho-NFE2L2 [nucleoplasm] (Canis familiaris)

phospho-NFE2L2 [nucleoplasm] (Sus scrofa)

phospho-Nfe2l2 [nucleoplasm] (Mus musculus)

phospho-Nfe2l2 [nucleoplasm] (Rattus norvegicus)

phospho-cnc [nucleoplasm] (Drosophila melanogaster)

phospho-p-S40-18 AcK-NFE2L2 [nucleoplasm] (Gallus gallus)

phospho-sknr-1 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 40

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

N6-acetyl-L-lysine at 438

Coordinate

438

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 443

Coordinate

443

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 445

Coordinate

445

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 462

Coordinate

462

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 472

Coordinate

472

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 487

Coordinate

487

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 506

Coordinate

506

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 508

Coordinate

508

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 516

Coordinate

516

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 518

Coordinate

518

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 533

Coordinate

533

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 536

Coordinate

536

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 538

Coordinate

538

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 541

Coordinate

541

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 543

Coordinate

543

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 548

Coordinate

548

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 554

Coordinate

554

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 555

Coordinate

555

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_001138884.1, NP_001138885.1, NP_006155.2, NP_001300829.1, NP_001300830.1

Guide to Pharmacology - Targets

3057

OpenTargets

ENSG00000116044

ENSEMBL

ENST00000446151, ENSP00000514370, ENST00000699330, ENST00000699434, ENST00000421929, ENST00000464747, ENSP00000400073, ENST00000397063, ENST00000397062, ENST00000699351, ENSP00000411575, ENSP00000514318, ENST00000448782, ENSP00000467401, ENSP00000380253, ENSP00000380252, ENST00000699409, ENST00000699408, ENST00000699328, ENSP00000412191, ENST00000699343, ENSP00000514386, ENSP00000514303, ENSP00000514369, ENSP00000514325, ENSP00000514304

ZINC - Substances

NF2L2_HUMAN

ZINC - Biogenic

NF2L2_HUMAN

ZINC target

Q16236

PRO

Q16236

GlyGen

Q16236

PDB

7K2A, 3ZGC, 7O7B, 7K2D, 7K2B, 2LZ1, 7X5F, 8EJR, 8EJS, 6T7V, 2FLU, 7K28, 7X5E, 7K2E, 7K2C, 7X5G, 7K2K, 5WFV, 4IFL, 7K29

HPA

ENSG00000116044-NFE2L2

Pharos - Targets

Q16236

ZINC - Predictions - Purchasable

NF2L2_HUMAN

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.978	39
UniProt:O15525 MAFG	1	MAFG [nucleoplasm] (R-HSA-1008212)	0.939	16
UniProt:O60675 MAFK	1	MAFK [nucleoplasm] (R-HSA-1008242)	0.806	7
UniProt:Q9ULX9 MAFF	1	MAFF [nucleoplasm] (R-HSA-1008261)	0.77	6
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.727	8
IntAct:EBI-4399559 UBIQ			0.667	3
UniProt:P13805 TNNT1	1	TNNT1 [cytosol] (R-HSA-390544)	0.666	4
UniProt:O60519 CRBL2			0.625	5
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.625	5
UniProt:O15144 ARPC2	1	ARPC2 [cytosol] (R-HSA-200809)	0.625	5
UniProt:P43268 ETV4	1	ETV4 [nucleoplasm] (R-HSA-5687030)	0.625	6
UniProt:P20226 TBP	1	TBP [nucleoplasm] (R-HSA-83718)	0.625	5
UniProt:Q10587 TEF			0.625	5
UniProt:P41212 ETV6	14	ETV6(1-384)-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703308) ETV6(1-154)insGSFILG-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703302) ETV6(1-336)insGCS-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703305) ETV6(1-301)-p-6Y-FLT3(574-993) fusion [cytosol] (R-HSA-9703318) ETV6(1-384)-p-3Y-FLT3(659-1620) fusion [cytosol] (R-HSA-9703313) ETV6(1-154)insGSFILG-FLT3(573-993) fusion [cytosol] (R-HSA-9703312) ETV6(1-336)insGCS-FLT3(573-993) fusion [cytosol] (R-HSA-9703320) ETV6(1-384)-FLT3(573-993) fusion [cytosol] (R-HSA-9703307) ETV6(1-301)-FLT3(574-993) fusion [cytosol] (R-HSA-9703315) ETV6(1-384)-FLT3(569-993) fusion [cytosol] (R-HSA-9697944) ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673898) ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673893) p-11Y-ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673905) p-12Y-ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673912)	0.625	5
UniProt:O75822 EIF3J	1	EIF3J [cytosol] (R-HSA-72534)	0.625	5
UniProt:Q9NS37 ZHANG			0.625	5
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.625	5
UniProt:P18847 ATF3	1	ATF3 [nucleoplasm] (R-HSA-535543)	0.625	5
UniProt:P53567 CEBPG	1	CEBPG [nucleoplasm] (R-HSA-9644320)	0.625	5
UniProt:P15408 FOSL2			0.625	6
UniProt:P53539 FOSB	1	FOSB [nucleoplasm] (R-HSA-9009922)	0.625	6
UniProt:P52564 MAP2K6	3	MAP2K6 [cytosol] (R-HSA-167998) p-S207,T211-MAP2K6 [cytosol] (R-HSA-206255) p-S207,T211-MAP2K6 [nucleoplasm] (R-HSA-450258)	0.625	5
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.625	5
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.625	5
UniProt:P41227 NAA10			0.602	4
UniProt:Q13342 SP140			0.581	4
UniProt:O94916 NFAT5			0.581	4
UniProt:P50549 ETV1			0.581	4
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.581	4
UniProt:P78545 ELF3	2	ELF3 [nucleoplasm] (R-HSA-9021353) p-S68-ELF3 [nucleoplasm] (R-HSA-9021349)	0.581	5
UniProt:Q9BTA9 WAC	1	WAC [nucleoplasm] (R-HSA-8942150)	0.556	3
UniProt:P13805-3 TNNT1			0.556	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.556	5
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.547	2
UniProt:P11416 Rara	3	Rara [nucleoplasm] (R-MMU-5618000) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-MMU-4341042) phospho-SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-MMU-5334830)	0.544	2
UniProt:Q60953	4	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-MMU-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-MMU-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-MMU-3000440) PML [nucleoplasm] (R-MMU-1031706)	0.544	2
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.524	2
UniProt:P15036 ETS2	2	ETS2 [nucleoplasm] (R-HSA-1629811) p-T72-ETS2 [nucleoplasm] (R-HSA-3132735)	0.508	2
UniProt:Q9UJU2 LEF1	2	pT155,S166-LEF1 [nucleoplasm] (R-HSA-4411389) LEF1 [nucleoplasm] (R-HSA-3214972)	0.508	3
UniProt:Q9ULD4 BRPF3	3	BRPF3 [extracellular region] (R-HSA-350700) BRPF3 [cytosol] (R-HSA-350716) BRPF3 [nucleoplasm] (R-HSA-3318471)	0.508	3
UniProt:Q96G23 CERS2	1	CERS2 [endoplasmic reticulum membrane] (R-HSA-428171)	0.508	2
UniProt:P27695 APEX1	1	APEX1 [nucleoplasm] (R-HSA-50119)	0.508	3
UniProt:P55210 CASP7	5	CASP7(24-198) [nucleoplasm] (R-HSA-351927) CASP7(207-303) [nucleoplasm] (R-HSA-351924) CASP7(2-303) [cytosol] (R-HSA-57029) CASP7(24-198) [cytosol] (R-HSA-141641) CASP7(207-303) [cytosol] (R-HSA-141642)	0.508	2
UniProt:P15976 GATA1	1	GATA1 [nucleoplasm] (R-HSA-996772)	0.508	2
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.508	2
UniProt:P19419 ELK1	2	ELK1 [nucleoplasm] (R-HSA-3009346) p-4S,T336-ELK1 [nucleoplasm] (R-HSA-3009350)	0.508	5
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.508	2
UniProt:Q6V702 CF299			0.508	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.508	2
UniProt:P10914 IRF1	2	IRF1 [nucleoplasm] (R-HSA-983456) IRF1 [cytosol] (R-HSA-1015686)	0.508	3
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.508	4
UniProt:Q77UU1 Q77UU1			0.488	2
UniProt:O95718-3 ESRRB			0.463	2

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