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CUL4A [nucleoplasm]
Stable Identifier
R-HSA-976006
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cullin-4A, CUL4A_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
DNA Damage Recognition in GG-NER (Homo sapiens)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
PARP1 or PARP2 binds DDB2 at GG-NER site (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
UV-DDB ubiquitinates XPC (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
UV-DDB:COP9 Signalosome [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Dual Incision in GG-NER (Homo sapiens)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Homo sapiens)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Formation of Incision Complex in GG-NER (Homo sapiens)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Homo sapiens)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Homo sapiens)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
CHD1L is recruited to GG-NER site (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Formation of the pre-incision complex in GG-NER (Homo sapiens)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Recruitment of XPA and release of CAK (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
SUMOylation of XPC (Homo sapiens)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
TFIIH binds GG-NER site to form a verification complex (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
ERCC5 and RPA bind TC-NER site (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
Assembly of the pre-incision complex in TC-NER (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4A [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
10585395
Cullin 4A associates with the UV-damaged DNA-binding protein DDB
Nag, A
,
Shiyanov, P
,
Raychaudhuri, P
J. Biol. Chem.
1999
External Reference Information
External Reference
UniProt:Q13619 CUL4A
Gene Names
CUL4A
Chain
chain:1-759
Reference Genes
BioGPS Gene:8451 CUL4A
COSMIC (genes):CUL4A CUL4A
CTD Gene:8451 CUL4A
dbSNP Gene:8451 CUL4A
ENSEMBL:ENSG00000139842 CUL4A
ENSEMBL_homo_sapiens_GENE:ENSG00000139842.15 CUL4A
HGNC:2554 CUL4A
KEGG Gene (Homo sapiens):8451 CUL4A
Monarch:8451 CUL4A
NCBI Gene:8451 CUL4A
OMIM:603137 CUL4A
UCSC:Q13619 CUL4A
Reference Transcript
RefSeq:NM_001008895.2 CUL4A
RefSeq:NM_001278513.1 CUL4A
RefSeq:NM_003589.2 CUL4A
RefSeq:XM_011537523.2 CUL4A
Other Identifiers
11743766_a_at
11748671_a_at
11752001_a_at
16776827
201423_PM_s_at
201423_s_at
201424_PM_s_at
201424_s_at
3502499
3502500
3502501
3502503
3502504
3502506
3502507
3502510
3502511
3502512
3502515
3502517
3502521
3502523
3502527
3502534
3502537
3502538
3502543
3502545
3502546
3502547
3502549
3502550
3502552
3502557
3502558
3502559
3502560
3502561
3502563
3502564
40908_r_at
7970262
8451
A_23_P151471
A_24_P61467
A_33_P3322909
GE873867
GO:0000082
GO:0000278
GO:0001701
GO:0002376
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0006281
GO:0006511
GO:0006974
GO:0007283
GO:0008283
GO:0008284
GO:0012501
GO:0016567
GO:0016740
GO:0022414
GO:0023052
GO:0030097
GO:0030154
GO:0030163
GO:0030853
GO:0031461
GO:0031464
GO:0031625
GO:0034644
GO:0035019
GO:0036211
GO:0042110
GO:0042254
GO:0043161
GO:0043226
GO:0045732
GO:0048511
GO:0048856
GO:0051246
GO:0061630
GO:0080008
GO:0097193
GO:0140096
GO:0140627
GO:0160072
GO:1900087
GO:2000001
GO:2000819
HMNXSV003006474
Hs.183874.0.A1_3p_a_at
ILMN_1686156
ILMN_1695792
ILMN_2331163
PH_hs_0023344
TC13000419.hg
U58090_at
g11140810_3p_a_at
Participates
as a member of
CUL4 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
G76-NEDD8-K705-CUL4A [nucleoplasm]
Inferred To
pcu4 [nucleoplasm]
(Schizosaccharomyces pombe)
cul-4 [nucleoplasm]
(Caenorhabditis elegans)
CUL4A [nucleoplasm]
(Bos taurus)
CUL4A [nucleoplasm]
(Canis familiaris)
CUL4A [nucleoplasm]
(Gallus gallus)
CUL4A [nucleoplasm]
(Plasmodium falciparum)
CUL4A [nucleoplasm]
(Sus scrofa)
cul4a [nucleoplasm]
(Danio rerio)
cul4a [nucleoplasm]
(Xenopus tropicalis)
culD [nucleoplasm]
(Dictyostelium discoideum)
Cul4 [nucleoplasm]
(Drosophila melanogaster)
Cul4a [nucleoplasm]
(Mus musculus)
Cul4a [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_003580.1
,
NP_001008895.1
,
XP_011535825.1
,
NP_001265442.1
OpenTargets
ENSG00000139842
GeneCards
Q13619
HPA
ENSG00000139842-CUL4A
Ensembl
ENST00000375441
,
ENSP00000389118
,
ENST00000451881
,
ENSP00000481782
,
ENSP00000364589
,
ENST00000375440
,
ENSG00000139842
,
ENSP00000364590
,
ENST00000617546
PRO
Q13619
Pharos - Targets
Q13619
PDB
7OPC
,
7OKQ
,
7OPD
,
4A0K
,
8B3I
,
2HYE
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92466 DDB2
3
PolyUb-DDB2 [nucleoplasm]
(R-HSA-6783035)
DDB2 [nucleoplasm]
(R-HSA-53491)
PAR-DDB2 [nucleoplasm]
(R-HSA-5696654)
0.886
12
UniProt:Q86VP6 CAND1
5
CAND1 [cytosol]
(R-HSA-5691146)
CAND1 [ficolin-1-rich granule lumen]
(R-HSA-6801399)
CAND1 [extracellular region]
(R-HSA-6806498)
CAND1 [secretory granule lumen]
(R-HSA-6801390)
CAND1 [nucleoplasm]
(R-HSA-8955089)
0.723
6
UniProt:Q96SW2 CRBN
1
CRBN [cytosol]
(R-HSA-8863300)
0.648
6
UniProt:P62877 RBX1
2
RBX1 [nucleoplasm]
(R-HSA-1234142)
RBX1 [cytosol]
(R-HSA-180582)
0.643
4
UniProt:O94888 WIPF1
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.623
7
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:P51959 CCNG1
1
CCNG1 [nucleoplasm]
(R-HSA-6792489)
0.527
3
UniProt:P19838 NFKB1
8
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.527
2
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.527
8
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [cytosol]
(R-HSA-1181251)
0.499
2
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