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CBLB [cytosol]
Stable Identifier
R-HSA-976009
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase CBL-B, CBLB_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13191 CBLB
Gene Names
CBLB, RNF56, Nbla00127
Chain
chain:1-982
Reference Genes
BioGPS Gene:868 CBLB
COSMIC (genes):CBLB CBLB
CTD Gene:868 CBLB
dbSNP Gene:868 CBLB
ENSEMBL:ENSG00000114423 CBLB
ENSEMBL_homo_sapiens_GENE:ENSG00000114423.23 CBLB
HGNC:1542 CBLB
Monarch:868 CBLB
NCBI Gene:868 CBLB
OMIM:604491 CBLB
UCSC:Q13191 CBLB
Reference Transcript
RefSeq:NM_170662.4 CBLB
RefSeq:NM_001321788.1 CBLB
RefSeq:XM_011513257.1 CBLB
Other Identifiers
11751090_a_at
11753986_a_at
11761083_a_at
11763212_at
16956983
208348_PM_s_at
208348_s_at
209682_PM_at
209682_at
227900_PM_at
227900_at
2687252
2687254
2687256
2687257
2687258
2687263
2687267
2687268
2687269
2687270
2687271
2687275
2687277
2687280
2687281
2687282
2687283
2687285
2687286
2687292
2687293
2687294
2687295
2687296
2687297
2687306
2687332
2687334
2687335
2687336
2687337
35632_at
514_at
515_s_at
56247_i_at
56250_r_at
61071_at
62255_at
79308_at
8089261
868
A_23_P212715
A_23_P29830
GE59036
GO:0001784
GO:0002376
GO:0002669
GO:0002870
GO:0003824
GO:0004842
GO:0005509
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006607
GO:0006886
GO:0006913
GO:0006955
GO:0007155
GO:0007165
GO:0007166
GO:0008270
GO:0016567
GO:0016740
GO:0017124
GO:0023051
GO:0023052
GO:0030155
GO:0030163
GO:0030971
GO:0031398
GO:0035556
GO:0035739
GO:0036211
GO:0042110
GO:0043226
GO:0045121
GO:0045732
GO:0046872
GO:0048856
GO:0050852
GO:0050860
GO:0061630
GO:0140096
GO:2000562
GO:2000583
HMNXSV003000769
HMNXSV003044872
Hs.144139.0.A1_3p_at
ILMN_1685580
PH_hs_0025558
TC03001624.hg
U26710_at
U26712_at
g4757919_3p_a_at
g862406_3p_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
sli-1 [cytosol]
(Caenorhabditis elegans)
Cbl [cytosol]
(Drosophila melanogaster)
CBLB [cytosol]
(Bos taurus)
CBLB [cytosol]
(Canis familiaris)
CBLB [cytosol]
(Gallus gallus)
CBLB [cytosol]
(Mus musculus)
CBLB [cytosol]
(Plasmodium falciparum)
CBLB [cytosol]
(Rattus norvegicus)
CBLB [cytosol]
(Sus scrofa)
CBLB [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
XP_011511559.1
,
NP_001308717.1
,
NP_733762.2
Guide to Pharmacology - Targets
3234
OpenTargets
ENSG00000114423
GeneCards
Q13191
HPA
ENSG00000114423-CBLB
Ensembl
ENST00000394030
,
ENST00000405772
,
ENSP00000377598
,
ENST00000403724
,
ENSG00000114423
,
ENSP00000384816
,
ENSP00000384938
PRO
Q13191
Pharos - Targets
Q13191
HMDB Protein
HMDBP07559
PDB
2DO6
,
2J6F
,
2OOB
,
2AK5
,
2BZ8
,
8GCY
,
2LDR
,
3PFV
,
2JNH
,
3VGO
,
3ZNI
,
2OOA
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.965
29
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.939
25
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.831
8
UniProt:Q9Y5K6 CD2AP
1
CD2AP [cytosol]
(R-HSA-373620)
0.747
11
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.683
4
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.621
4
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.621
4
UniProt:Q9UKW4 VAV3
2
VAV3 [cytosol]
(R-HSA-430152)
p-Y173-VAV3 [cytosol]
(R-HSA-442287)
0.556
3
UniProt:P07947 YES1
2
MyrG-p-Y426-YES1 [plasma membrane]
(R-HSA-1810411)
YES1 [cytosol]
(R-HSA-373640)
0.556
3
UniProt:Q01658 DR1
1
DR1 [nucleoplasm]
(R-HSA-3662280)
0.556
3
UniProt:O76003 GLRX3
1
GLRX3 [cytosol]
(R-HSA-5691202)
0.556
3
UniProt:Q13882 PTK6
5
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
PTK6 [cytosol]
(R-HSA-8848000)
0.556
3
UniProt:P00441 SOD1
5
SOD1 [extracellular region]
(R-HSA-350705)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
0.556
3
UniProt:Q00403 GTF2B
1
GTF2B [nucleoplasm]
(R-HSA-65888)
0.556
3
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.508
2
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.488
2
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