Reactome | RBCK1 [cytosol]

RBCK1 [cytosol]

Stable Identifier

R-HSA-976018

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RanBP-type and C3HC4-type zinc finger-containing protein 1, UB7I3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BYM8 RBCK1

Gene Names

RBCK1, C20orf18, RNF54, UBCE7IP3, XAP3, XAP4

Chain

chain:1-510

Reference Genes

BioGPS Gene:10616 RBCK1

COSMIC (genes):RBCK1 RBCK1

CTD Gene:10616 RBCK1

dbSNP Gene:10616 RBCK1

ENSEMBL:ENSG00000125826 RBCK1

HGNC:15864 RBCK1

KEGG Gene (Homo sapiens):10616 RBCK1

Monarch:10616 RBCK1

NCBI Gene:10616 RBCK1

OMIM:610924 RBCK1

UCSC:Q9BYM8 RBCK1

Reference Transcript

Other Identifiers

0002810717

10616

11735723_s_at

11752690_a_at

11756449_x_at

11761110_x_at

16910618

207713_s_at

229920_at

32202_at

3873184

3873186

3873187

3873188

3873191

3873192

3873200

3873201

3873202

3873203

3873208

3873209

3873212

3873213

3873215

3873217

3873218

3873220

3873222

3873223

3873224

3873225

3873230

3873232

50146_at

8060353

A_23_P166051

A_33_P3238315

A_33_P3238323

GE549071

GE62827

GO:0000151

GO:0000209

GO:0002376

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0006464

GO:0007165

GO:0007249

GO:0008150

GO:0008219

GO:0009056

GO:0009058

GO:0010803

GO:0016032

GO:0016740

GO:0032088

GO:0032182

GO:0032991

GO:0034641

GO:0042802

GO:0043065

GO:0043123

GO:0043130

GO:0043161

GO:0043167

GO:0044403

GO:0046872

GO:0050852

GO:0051092

GO:0060546

GO:0071797

GO:0097039

GO:1901224

GO:2001238

Hs.247280.3.A1_3p_a_at

Hs.247280.3.A1_3p_x_at

Hs.29546.0.S1_3p_at

ILMN_1751330

ILMN_2406313

PH_hs_0013094

TC20000010.hg

g5454167_3p_a_at

Participant Of

hasMember

E3 ligases in proteasomal degradation [cytosol]

hasComponent

LUBAC [cytosol]

Inferred To

rbck1 [cytosol] (Danio rerio)

Ghost homologue of RBCK1 [cytosol] (Xenopus tropicalis)

RBCK1 [cytosol] (Bos taurus)

RBCK1 [cytosol] (Caenorhabditis elegans)

RBCK1 [cytosol] (Canis familiaris)

RBCK1 [cytosol] (Sus scrofa)

Rbck1 [cytosol] (Mus musculus)

Rbck1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_006453.1, NP_112506.2

OpenTargets

ENSG00000125826

GeneCards

Q9BYM8

HPA

ENSG00000125826-RBCK1

Ensembl

ENSP00000348632, ENSG00000125826, ENST00000353660, ENST00000356286, ENSP00000254960

PRO

Q9BYM8

Orphanet

22007

PDB

4DBG, 2CRC, 2LGY

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-NEMO [cytosol] (R-HSA-202530) IKBKG [cytosol] (R-HSA-168108)	0.858	9
UniProt:Q9H0F6 SHARPIN	1	SHARPIN [cytosol] (R-HSA-5212666)	0.829	26
UniProt:O14933 UBE2L6	2	UBE2L6 [cytosol] (R-HSA-936014) UBE2L6 [nucleoplasm] (R-HSA-5653666)	0.781	7
UniProt:P01375 TNF	5	TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.725	6
UniProt:P68036 UBE2L3	4	UBE2L3 [nucleoplasm] (R-HSA-8852056) Ub-C86-UBE2L3 [nucleoplasm] (R-HSA-8864226) Ub-C86-UBE2L3 [cytosol] (R-HSA-8864201) UBE2L3 [cytosol] (R-HSA-947631)	0.666	4
UniProt:P61088 UBE2N	5	Ub-C87-UBE2N [cytosol] (R-HSA-8864210) Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) UBE2N [nucleoplasm] (R-HSA-5682541) UBE2N [cytosol] (R-HSA-206072)	0.592	2
UniProt:Q9JLY0 Socs6	2	Socs6 [cytosol] (R-MMU-1469969) Socs6 [cytosol] (R-MMU-1469973)	0.581	5
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.57	3
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.556	3
UniProt:Q9BU61 NDUFAF3	1	NDUFAF3 [mitochondrial inner membrane] (R-HSA-5689126)	0.556	3
UniProt:Q8IVS8 GLYCTK	1	GLYCTK [cytosol] (R-HSA-6799244)	0.556	3