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RBCK1 [cytosol]
Stable Identifier
R-HSA-976018
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RanBP-type and C3HC4-type zinc finger-containing protein 1, UB7I3_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
LUBAC comlex binds OTULIN (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
LUBAC:OTULIN [cytosol] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
TNFR1-induced NFkappaB signaling pathway (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
TNFalpha:TNF-R1:TRADD:K63polyUb-RIP1:BIRC2/3:IKKA:IKKB:NEMO [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RBCK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BYM8 RBCK1
Gene Names
RBCK1, C20orf18, RNF54, UBCE7IP3, XAP3, XAP4
Chain
chain:1-510
Reference Genes
BioGPS Gene:10616 RBCK1
COSMIC (genes):RBCK1 RBCK1
CTD Gene:10616 RBCK1
dbSNP Gene:10616 RBCK1
ENSEMBL:ENSG00000125826 RBCK1
HGNC:15864 RBCK1
KEGG Gene (Homo sapiens):10616 RBCK1
Monarch:10616 RBCK1
NCBI Gene:10616 RBCK1
OMIM:610924 RBCK1
UCSC:Q9BYM8 RBCK1
Reference Transcript
RefSeq:NM_006462.5 RBCK1
RefSeq:NM_031229.3 RBCK1
Other Identifiers
0002810717
10616
11735723_s_at
11752690_a_at
11756449_x_at
11761110_x_at
16910618
207713_s_at
229920_at
32202_at
3873184
3873186
3873187
3873188
3873191
3873192
3873200
3873201
3873202
3873203
3873208
3873209
3873212
3873213
3873215
3873217
3873218
3873220
3873222
3873223
3873224
3873225
3873230
3873232
50146_at
8060353
A_23_P166051
A_33_P3238315
A_33_P3238323
GE549071
GE62827
GO:0000151
GO:0000209
GO:0002376
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0006464
GO:0007165
GO:0007249
GO:0008150
GO:0008219
GO:0009056
GO:0009058
GO:0010803
GO:0016032
GO:0016740
GO:0032088
GO:0032182
GO:0032991
GO:0034641
GO:0042802
GO:0043065
GO:0043123
GO:0043130
GO:0043161
GO:0043167
GO:0044403
GO:0046872
GO:0050852
GO:0051092
GO:0060546
GO:0071797
GO:0097039
GO:1901224
GO:2001238
Hs.247280.3.A1_3p_a_at
Hs.247280.3.A1_3p_x_at
Hs.29546.0.S1_3p_at
ILMN_1751330
ILMN_2406313
PH_hs_0013094
TC20000010.hg
g5454167_3p_a_at
Participant Of
hasMember
E3 ligases in proteasomal degradation [cytosol]
hasComponent
LUBAC [cytosol]
Inferred To
rbck1 [cytosol] (Danio rerio)
Ghost homologue of RBCK1 [cytosol] (Xenopus tropicalis)
RBCK1 [cytosol] (Bos taurus)
RBCK1 [cytosol] (Caenorhabditis elegans)
RBCK1 [cytosol] (Canis familiaris)
RBCK1 [cytosol] (Sus scrofa)
Rbck1 [cytosol] (Mus musculus)
Rbck1 [cytosol] (Rattus norvegicus)
Cross References
RefSeq
NP_006453.1
,
NP_112506.2
OpenTargets
ENSG00000125826
HPA
ENSG00000125826-RBCK1
GeneCards
Q9BYM8
Ensembl
ENST00000353660
,
ENSP00000254960
,
ENSG00000125826
,
ENST00000356286
,
ENSP00000348632
PRO
Q9BYM8
Orphanet
22007
PDB
2LGY
,
2CRC
,
4DBG
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6K9 IKBKG
12
IKBKG [nucleoplasm]
(R-HSA-4755413)
SUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
IKBKG [cytosol]
(R-HSA-168108)
0.858
9
UniProt:Q9H0F6 SHARPIN
1
SHARPIN [cytosol]
(R-HSA-5212666)
0.829
26
UniProt:O14933 UBE2L6
2
UBE2L6 [cytosol]
(R-HSA-936014)
UBE2L6 [nucleoplasm]
(R-HSA-5653666)
0.781
7
UniProt:P01375 TNF
5
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.725
6
UniProt:P68036 UBE2L3
4
UBE2L3 [nucleoplasm]
(R-HSA-8852056)
Ub-C86-UBE2L3 [nucleoplasm]
(R-HSA-8864226)
Ub-C86-UBE2L3 [cytosol]
(R-HSA-8864201)
UBE2L3 [cytosol]
(R-HSA-947631)
0.666
4
UniProt:P61088 UBE2N
5
Ub-C87-UBE2N [cytosol]
(R-HSA-8864210)
Ub-C87-UBE2N [nucleoplasm]
(R-HSA-8943013)
K63polyUb-C87-UBE2N [nucleoplasm]
(R-HSA-6790511)
UBE2N [nucleoplasm]
(R-HSA-5682541)
UBE2N [cytosol]
(R-HSA-206072)
0.592
2
UniProt:Q9JLY0 Socs6
2
Socs6 [cytosol]
(R-MMU-1469969)
Socs6 [cytosol]
(R-MMU-1469973)
0.581
5
UniProt:P09022 Hoxa1
1
Hoxa1 [nucleoplasm]
(R-MMU-5617924)
0.57
3
UniProt:Q8N0S2 SYCE1
1
SYCE1 [nucleoplasm]
(R-HSA-912456)
0.556
3
UniProt:Q9BU61 NDUFAF3
1
NDUFAF3 [mitochondrial inner membrane]
(R-HSA-5689126)
0.556
3
UniProt:Q8IVS8 GLYCTK
1
GLYCTK [cytosol]
(R-HSA-6799244)
0.556
3
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