Reactome | SPSB1 [cytosol]

SPSB1 [cytosol]

Stable Identifier

R-HSA-976024

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SPRY domain-containing SOCS box protein 1, SPSB1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB1 [cytosol] (Homo sapiens)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB1 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB1 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB1 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB1 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB1 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB1 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB1 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB1 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96BD6 SPSB1

Gene Names

SPSB1, SSB1

Chain

chain:1-273

Reference Genes

BioGPS Gene:80176 SPSB1

COSMIC (genes):SPSB1 SPSB1

CTD Gene:80176 SPSB1

dbSNP Gene:80176 SPSB1

ENSEMBL:ENSG00000171621 SPSB1

ENSEMBL_homo_sapiens_GENE:ENSG00000171621.14 SPSB1

HGNC:30628 SPSB1

KEGG Gene (Homo sapiens):80176 SPSB1

Monarch:80176 SPSB1

NCBI Gene:80176 SPSB1

OMIM:611657 SPSB1

UCSC:Q96BD6 SPSB1

Reference Transcript

RefSeq:NM_025106.3 SPSB1

Other Identifiers

11719259_s_at

16658655

219677_PM_at

219677_at

226075_PM_at

226075_at

2319253

2319275

2319277

2319278

2319279

2319282

2319283

2319284

2319285

2319286

2319287

2319288

2319289

55061_at

7897449

80176

A_23_P200096

A_24_P96961

GE54885

GO:0005515

GO:0005737

GO:0005829

GO:0006511

GO:0016567

GO:0019005

GO:0030163

GO:0036211

GO:0043161

GO:0060090

GO:1990756

HMNXSV003007978

Hs.8261.0.S1_3p_at

ILMN_1714170

PH_hs_0028533

TC01000115.hg

g13376674_3p_at

Participates

as a member of

Inferred To

SPSB1 [cytosol] (Bos taurus)

SPSB1 [cytosol] (Canis familiaris)

SPSB1 [cytosol] (Dictyostelium discoideum)

SPSB1 [cytosol] (Gallus gallus)

SPSB1 [cytosol] (Rattus norvegicus)

SPSB1 [cytosol] (Sus scrofa)

spsb-1 [cytosol] (Caenorhabditis elegans)

Spsb1 [cytosol] (Mus musculus)

fi35c01 [cytosol] (Danio rerio)

gus [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_079382.2

OpenTargets

ENSG00000171621

HPA

ENSG00000171621-SPSB1

GeneCards

Q96BD6

Ensembl

ENSP00000330221, ENSP00000366616, ENSG00000171621, ENST00000377399, ENST00000328089, ENST00000357898, ENSP00000350573

PRO

Q96BD6

Pharos - Targets

Q96BD6

PDB

2JK9, 3F2O

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13153 PAK1	5	PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) Active PAK1 [cytosol] (R-HSA-8964622) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.556	3
UniProt:P06307 CCK	1	CCK [extracellular region] (R-HSA-388539)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:P16284 PECAM1	4	PECAM1 [plasma membrane] (R-HSA-114686) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [secretory granule membrane] (R-HSA-6804778) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:Q96LA8 PRMT6	1	PRMT6 [nucleoplasm] (R-HSA-5226884)	0.508	2
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.508	2
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.508	2