Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
UBOX5 [cytosol]
Stable Identifier
R-HSA-976034
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RING finger protein 37, RNF37_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBOX5 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBOX5 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBOX5 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBOX5 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBOX5 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBOX5 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBOX5 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBOX5 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBOX5 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBOX5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94941 UBOX5
Gene Names
UBOX5, KIAA0860, RNF37, UBCE7IP5, UIP5
Chain
chain:1-541
Reference Genes
BioGPS Gene:22888 UBOX5
COSMIC (genes):UBOX5 UBOX5
CTD Gene:22888 UBOX5
dbSNP Gene:22888 UBOX5
ENSEMBL:ENSG00000185019 UBOX5
HGNC:17777 UBOX5
KEGG Gene (Homo sapiens):22888 UBOX5
Monarch:22888 UBOX5
NCBI Gene:22888 UBOX5
UCSC:O94941 UBOX5
Reference Transcript
RefSeq:NM_014948.3 UBOX5
RefSeq:NM_199415.2 UBOX5
Other Identifiers
0003130647
11722985_a_at
11722986_a_at
16916644
204598_at
215544_s_at
22888
35161_at
3895230
3895231
3895233
3895234
3895235
3895236
3895237
3895238
3895239
3895240
3895241
3895243
3895246
3895247
3895248
3895249
3895250
3895251
3895252
3895271
A_24_P23067
A_24_P79241
GE53545
GO:0000209
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005925
GO:0006464
GO:0008150
GO:0016567
GO:0016604
GO:0016740
GO:0019899
GO:0031625
GO:0034450
GO:0043167
GO:0043226
GO:0046872
GO:0061630
Hs.26009.1.S1_3p_a_at
ILMN_1652872
ILMN_1774784
PH_hs_0002292
PH_hs_0033482
TC20000568.hg
g7662343_3p_at
Participant Of
hasCandidate
E3 ligases in proteasomal degradation [cytosol]
Inferred To
ubox5 [cytosol] (Danio rerio)
Ubox5 [cytosol] (Mus musculus)
Ubox5 [cytosol] (Rattus norvegicus)
UBOX5 [cytosol] (Bos taurus)
UBOX5 [cytosol] (Canis familiaris)
UBOX5 [cytosol] (Gallus gallus)
UBOX5 [cytosol] (Sus scrofa)
UBOX5 [cytosol] (Xenopus tropicalis)
UIP5 [cytosol] (Drosophila melanogaster)
Cross References
RefSeq
NP_055763.1
,
NP_955447.1
OpenTargets
ENSG00000185019
HPA
ENSG00000185019-UBOX5
GeneCards
O94941
Ensembl
ENST00000348031
,
ENSP00000217173
,
ENSP00000311726
,
ENSG00000185019
,
ENST00000217173
PRO
O94941
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40692 MLH1
3
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.8
6
UniProt:P55072 VCP
8
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [cytosol]
(R-HSA-1181251)
0.556
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text