Reactome | FBXW11 [cytosol]

FBXW11 [cytosol]

Stable Identifier

R-HSA-976035

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

F-box/WD repeat-containing protein 11, FBW1B_HUMAN

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G2-G2/M phases (Homo sapiens)
    - G2/M Transition (Homo sapiens)
      - Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
        
        Phosphorylated BORA binds SCF-beta-TrCp1/2 (Homo sapiens)
        
        (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
        
        CUL1:FBXW11:SKP1 [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
        
        p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] (Homo sapiens)
        
        (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
        
        CUL1:FBXW11:SKP1 [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
        
        SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Homo sapiens)
        
        (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
        
        CUL1:FBXW11:SKP1 [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
        
        p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] (Homo sapiens)
        
        (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
        
        CUL1:FBXW11:SKP1 [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UKB1 FBXW11

Gene Names

FBXW11, BTRCP2, FBW1B, FBXW1B, KIAA0696

Chain

chain:1-542

Reference Genes

BioGPS Gene:23291 FBXW11

COSMIC (genes):FBXW11 FBXW11

CTD Gene:23291 FBXW11

dbSNP Gene:23291 FBXW11

ENSEMBL:ENSG00000072803 FBXW11

HGNC:13607 FBXW11

KEGG:hsa:23291 FBXW11

Monarch:23291 FBXW11

NCBI Gene:23291 FBXW11

OMIM:605651 FBXW11

UCSC:Q9UKB1 FBXW11

Reference Transcript

Participates

as a member of

as a component of

CUL1:FBXW11:SKP1 [cytosol] (Homo sapiens)

Other forms of this molecule

FBXW11 [nucleoplasm]

Inferred To

Lis-1 [cytosol] (Drosophila melanogaster)

agtA [cytosol] (Dictyostelium discoideum)

wdr-5.3 [cytosol] (Caenorhabditis elegans)

lis-1 [cytosol] (Caenorhabditis elegans)

Fbxw11 [cytosol] (Mus musculus)

Fbxw11 [cytosol] (Rattus norvegicus)

Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)

Homologues of FBXW11 [cytosol] (Dictyostelium discoideum)

pop1 [cytosol] (Schizosaccharomyces pombe)

PAC1 [cytosol] (Saccharomyces cerevisiae)

pafah1b1 [cytosol] (Xenopus tropicalis)

pafah1b1a [cytosol] (Danio rerio)

FBXW11 [cytosol] (Canis familiaris)

FBXW11 [cytosol] (Dictyostelium discoideum)

FBXW11 [cytosol] (Gallus gallus)

wdr-5.2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_387449.2, NP_387448.2, NP_036432.2, NP_001365909.1

OpenTargets

ENSG00000072803

ENSEMBL

ENSP00000377391, ENST00000296933, ENST00000393802, ENST00000265094, ENSG00000072803, ENSP00000296933, ENSP00000265094

GeneCards

FBXW11

HPA

ENSG00000072803-FBXW11

PRO

Q9UKB1

Pharos - Targets

Q9UKB1

Orphanet

FBXW11

PDB

6WNX

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.939	15
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.928	14
UniProt:P30304 CDC25A	20	CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) PolyUb-p-S76,S79,T80,S82-CDC25A [nucleoplasm] (R-HSA-9944031) PolyUb-p-S76,S79,S82,S124-CDC25A [nucleoplasm] (R-HSA-9944025) PolyUb-p-S76,S79,S82,S124,S178,S279,S293-CDC25A [nucleoplasm] (R-HSA-9944029) PolyUb-p-S76,S79,T80,S82,S88-CDC25A [nucleoplasm] (R-HSA-9944023) PolyUb-p-S76,S79,S82,S88,S124-CDC25A [nucleoplasm] (R-HSA-9944028) PolyUb-p-S76,S79,S82,S88,S124,S178,S279,S293-CDC25A [nucleoplasm] (R-HSA-9944027) p-S76,S79,S82,S124-CDC25A [nucleoplasm] (R-HSA-9944026) p-S76,S79,T80,S82-CDC25A [nucleoplasm] (R-HSA-9944024) p-S76,S79,S82,S124,S178,S279,S293-CDC25A [nucleoplasm] (R-HSA-9944032) p-S76,S79,T80,S82,S88-CDC25A [nucleoplasm] (R-HSA-9943707) p-S76,S79,S82,S88,S124-CDC25A [nucleoplasm] (R-HSA-9943704) p-S76,S79,S82,S88,S124,S178,S279,S293-CDC25A [nucleoplasm] (R-HSA-9943711) p-S76,S124-CDC25A [nucleoplasm] (R-HSA-9942581) p-S76,T80-CDC25A [nucleoplasm] (R-HSA-9943698) p-S76,S124,S178,S279,S293-CDC25A [nucleoplasm] (R-HSA-143488) p-S124,S178,S293-CDC25A [nucleoplasm] (R-HSA-9941808) p-T80-CDC25A [nucleoplasm] (R-HSA-9943689) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634)	0.816	7
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.744	7
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926)	0.723	4
UniProt:Q5JTC6 AMER1	5	AMER1 [cytosol] (R-HSA-1504189) AMER1 R353* [cytosol] (R-HSA-9663939) AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 R497* [cytosol] (R-HSA-9663943)	0.708	6
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.69	6
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.669	3
UniProt:Q15653 NFKBIB	3	NFKBIB [cytosol] (R-HSA-168132) p-S19,S23-NFKBIB [cytosol] (R-HSA-177670) p-S19,S23-Ub-NFKBIB [cytosol] (R-HSA-1168571)	0.65	3
UniProt:O60285 NUAK1	2	p-T211-NUAK1 [nucleoplasm] (R-HSA-3222011) NUAK1 [nucleoplasm] (R-HSA-3222004)	0.643	3
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.643	5
UniProt:Q9Y4X5 ARIH1	1	ARIH1 [cytosol] (R-HSA-1678825)	0.643	3
UniProt:P30305 CDC25B	4	CDC25B [nucleoplasm] (R-HSA-69734) CDC25B [cytosol] (R-HSA-157412) p-S-CDC25B [nucleoplasm] (R-HSA-9929936) p-S50,T69,S160,S321,S470-CDC25B [cytosol] (R-HSA-8863644)	0.643	4
UniProt:Q9Y266 NUDC	4	NUDC [cytosol] (R-HSA-377731) NUDC [nucleoplasm] (R-HSA-156716) p-S274,S326-NUDC [cytosol] (R-HSA-156702) p-S274,S326-NUDC [spindle] (R-HSA-9648125)	0.643	4
UniProt:O00418 EEF2K	2	EEF2K [cytosol] (R-HSA-165745) p-S366-EEF2K [cytosol] (R-HSA-165755)	0.643	3
UniProt:Q13127 REST	1	REST [nucleoplasm] (R-HSA-480506)	0.623	3
UniProt:P30291 WEE1	4	WEE1 [nucleoplasm] (R-HSA-69253) p-WEE1 [nucleoplasm] (R-HSA-156491) p-S53-WEE1 [nucleoplasm] (R-HSA-156694) p-T187,T190-WEE1 [nucleoplasm] (R-HSA-9929669)	0.604	3
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.558	4
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.527	2
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.527	3
UniProt:Q53EL6 PDCD4	1	PDCD4 [cytosol] (R-HSA-5432887)	0.527	2
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.527	2
UniProt:Q13188 STK3	4	STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) STK3(323-491) [cytosol] (R-HSA-2028684) p-T180-STK3(1-322) [cytosol] (R-HSA-2028696)	0.527	2
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.527	3
UniProt:Q96HN2 AHCYL2	1	AHCYL2 [cytosol] (R-HSA-8878665)	0.527	3
UniProt:Q8IX03 WWC1	1	WWC1 [cytosol] (R-HSA-2038400)	0.527	2
UniProt:Q96MU7 YTHDC1	1	YTHDC1 [nucleoplasm] (R-HSA-9935812)	0.527	2
UniProt:O95235 KIF20A	3	KIF20A [cytosol] (R-HSA-1015868) p-S528-KIF20A [nucleoplasm] (R-HSA-156685) KIF20A [nucleoplasm] (R-HSA-156721)	0.527	2
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) STK4(327-487) [cytosol] (R-HSA-2028668) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682)	0.527	2
UniProt:Q9HD67 MYO10	1	MYO10 [cytosol] (R-HSA-593679)	0.527	2
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.524	4
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	4

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