Reactome | KEAP1 [cytosol]

KEAP1 [cytosol]

Stable Identifier

R-HSA-976038

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Kelch-like ECH-associated protein 1, KEAP1_HUMAN, KLHL19, KIAA0132

Locations in the PathwayBrowser for interactor UniProt:Q9NX09 DDIT4

Expand all

External Reference Information

External Reference

UniProt:Q14145 KEAP1

Gene Names

KEAP1, INRF2, KIAA0132, KLHL19

Chain

chain:1-624

Reference Genes

BioGPS Gene:9817 KEAP1

COSMIC (genes):KEAP1 KEAP1

CTD Gene:9817 KEAP1

dbSNP Gene:9817 KEAP1

ENSEMBL:ENSG00000079999 KEAP1

HGNC:23177 KEAP1

KEGG:hsa:9817 KEAP1

Monarch:9817 KEAP1

NCBI Gene:9817 KEAP1

OMIM:606016 KEAP1

UCSC:Q14145 KEAP1

Reference Transcript

Other Identifiers

11716444_a_at

16868743

202417_PM_at

202417_at

35322_at

3850364

3850365

3850366

3850367

3850368

3850369

3850370

3850371

3850372

3850373

3850374

3850375

3850376

3850377

3850378

3850379

3850380

3850381

3850383

3850385

8034034

9817

A_23_P119141

D50922_at

GE57257

GO:0000122

GO:0001701

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005829

GO:0005884

GO:0006355

GO:0006511

GO:0006979

GO:0010506

GO:0016234

GO:0016567

GO:0030163

GO:0030496

GO:0031463

GO:0032436

GO:0032991

GO:0034451

GO:0034599

GO:0042802

GO:0043161

GO:0045604

GO:0048856

GO:0060090

GO:0061629

GO:0070936

GO:0071353

GO:0097718

GO:0140416

GO:1902883

GO:1990756

HMNXSV003035494

ILMN_1711787

ILMN_2410771

ILMN_2410772

PH_hs_0003698

TC19001166.hg

g6912451_3p_at

Participates

as a member of

as an output of

NFE2L2 dependent KEAP1 expression (Homo sapiens)

as a component of

Other forms of this molecule

ub-KEAP1 [cytosol]

Ub-KEAP1 [cytosol]

Inferred To

Homologues of KEAP1 [cytosol] (Plasmodium falciparum)

Keap1 [cytosol] (Drosophila melanogaster)

Keap1 [cytosol] (Mus musculus)

Keap1 [cytosol] (Rattus norvegicus)

KEAP1 [cytosol] (Bos taurus)

KEAP1 [cytosol] (Canis familiaris)

KEAP1 [cytosol] (Dictyostelium discoideum)

KEAP1 [cytosol] (Plasmodium falciparum)

KEAP1 [cytosol] (Sus scrofa)

Ghost homologue of KEAP1 [cytosol] (Caenorhabditis elegans)

Ghost homologue of KEAP1 [cytosol] (Gallus gallus)

Ghost homologue of KEAP1 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of KEAP1 [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of KEAP1 [cytosol] (Xenopus tropicalis)

keap1b [cytosol] (Danio rerio)

Cross References

RefSeq

XP_011526754.1, NP_987096.1, NP_036421.2, XP_005260230.1, XP_005260231.1

Guide to Pharmacology - Targets

2757

OpenTargets

ENSG00000079999

ENSEMBL

ENST00000171111, ENST00000393623, ENSP00000377245, ENSG00000079999, ENSP00000171111

ZINC - Substances

KEAP1_HUMAN

ZINC target

Q14145

PRO

Q14145

GlyGen

Q14145

PDB

7K2N, 3VNG, 7K2I, 6WCQ, 7K2G, 8EHV, 5WIY, 4IQK, 6W69, 5WFL, 6FFM, 4CXI, 1U6D, 4XMB, 9DU7, 4L7D, 7K2D, 6SP4, 6ROG, 8PKS, 7K29, 7XOT, 7K2S, 8WFG, 5GIT, 5WHL, 7K2M, 7K2F, 4IFN, 7K2O, 3VNH, 7XM5, 5NLB, 6TYM, 3ZGC, 5WG1, 4CXJ, 4IFL, 5WFV, 7X4W, 6UF0, 2FLU, 7Q8R, 8PKX, 6T7V, 6T7Z, 7K2A, 4L7B, 8PKW, 7K2E, 6W66, 1ZGK, 8IVG, 6Z6A, 6TG8, 7Q6Q, 7K2J, 7EXI, 7K2P, 6TYP, 7XM4, 6SP1, 4CXT, 7X4X, 5WHO, 8EJS, 6LRZ, 6W68, 5DAD, 8XGV, 6V6Z, 4IN4, 8X34, 7K2B, 8PKU, 9ETX, 6HWS, 7Q6S, 7XM2, 5X54, 7K2L, 7K2H, 6FMQ, 7K2Q, 4N1B, 7K2R, 8IXS, 6FMP, 6W67, 5DAF, 7K2K, 4IFJ, 8XGK, 7Q96, 8EJR, 4L7C, 8IVR, 7K2C, 8PKV, 7K28, 9ETY, 7Q5H, 7XM3, 5F72, 3ZGD

GeneCards

KEAP1

HPA

ENSG00000079999-KEAP1

Pharos - Targets

Q14145

ZINC - Predictions - Purchasable

KEAP1_HUMAN

Interactors (79)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.98	41
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.967	21
UniProt:Q9NY33 DPP3	1	DPP3 [cytosol] (R-HSA-9795741)	0.907	13
UniProt:P62495 ETF1	3	ETF1 [cytosol] (R-HSA-54433) 4OHK63-ETF1 [cytosol] (R-HSA-9629948) Me-Q185-ETF1 [cytosol] (R-HSA-6800157)	0.831	8
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.831	8
UniProt:Q86YC2 PALB2	20	PALB2 Y28C [nucleoplasm] (R-HSA-9724169) PALB2 L35P [nucleoplasm] (R-HSA-9724168) PALB2 L24S [nucleoplasm] (R-HSA-9724172) PALB2 L21A [nucleoplasm] (R-HSA-9704339) PALB2 R37H [nucleoplasm] (R-HSA-9724178) PALB2 L21F [nucleoplasm] (R-HSA-9704347) PALB2 E12* [nucleoplasm] (R-HSA-9704349) PALB2 R37C [nucleoplasm] (R-HSA-9724188) PALB2 L35F [nucleoplasm] (R-HSA-9704338) PALB2 L947F [nucleoplasm] (R-HSA-9724554) PALB2 G1043D [nucleoplasm] (R-HSA-9724584) PALB2 T1030I [nucleoplasm] (R-HSA-9704424) PALB2 T841Qfs10 [nucleoplasm] (R-HSA-9704749) PALB2 L1119P [nucleoplasm] (R-HSA-9724589) PALB2 L947S [nucleoplasm] (R-HSA-9724557) PALB2 L1143P [nucleoplasm] (R-HSA-9704428) PALB2 L1070P [nucleoplasm] (R-HSA-9724556) PALB2 C77Vfs100 [nucleoplasm] (R-HSA-9704738) PALB2 L939W [nucleoplasm] (R-HSA-9704417) PALB2 L961P [nucleoplasm] (R-HSA-9724583)	0.8	6
UniProt:Q9BRX9 WDR83	1	WDR83 [endosome membrane] (R-HSA-5672942)	0.781	7
UniProt:P02724 GYPA	1	GYPA [plasma membrane] (R-HSA-8867204)	0.781	7
UniProt:O95198 KLHL2	1	KLHL2 [cytosol] (R-HSA-8863217)	0.77	7
UniProt:Q9Y3Q8 T22D4			0.758	5
UniProt:P62310 LSM3	2	LSM3 [nucleoplasm] (R-HSA-6806807) LSM3 [cytosol] (R-HSA-429894)	0.718	6
UniProt:P54619 PRKAG1	3	PRKAG1 [cytosol] (R-HSA-380946) PRKAG1 [nucleoplasm] (R-HSA-2151202) PRKAG1 [endoplasmic reticulum lumen] (R-HSA-9931308)	0.718	6
UniProt:Q6P1L5 F117B			0.718	6
UniProt:P06454-2 PTMA			0.718	6
UniProt:Q96TA1 NIBA2			0.718	9
UniProt:Q6P9E2 Q6P9E2			0.718	6
UniProt:Q14494 NF2L1			0.704	28
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.681	16
UniProt:Q9UH77 KLHL3	1	KLHL3 [cytosol] (R-HSA-8863198)	0.666	5
UniProt:Q9NPC3 CIP1			0.666	4
UniProt:Q13618 CUL3	3	CUL3 [cytosol] (R-HSA-975979) CUL3 [nucleoplasm] (R-HSA-5635033) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.666	5
UniProt:O14525-2 ASTN1			0.618	4
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.61	6
UniProt:P45381 ASPA	1	ASPA [cytosol] (R-HSA-5691513)	0.601	4
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.592	4
UniProt:O95166 GABARAP	3	GABARAP [cytosol] (R-HSA-975521) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [autophagosome membrane] (R-HSA-5683634)	0.59	5
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:B8Q183 B8Q183			0.556	4
UniProt:Q9NX09 DDIT4	1	DDIT4 [cytosol] (R-HSA-5632374)	0.556	3
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.556	3
UniProt:P02458-1 COL2A1			0.556	3
UniProt:Q2NKX9 CB068			0.556	3
UniProt:P05107 ITGB2	4	ITGB2 [plasma membrane] (R-HSA-198010) ITGB2 [ficolin-1-rich granule membrane] (R-HSA-6803310) ITGB2 [specific granule membrane] (R-HSA-6803284) ITGB2 [tertiary granule membrane] (R-HSA-6803342)	0.556	3
UniProt:A9UGY9 A9UGY9			0.556	3
UniProt:Q14440 Q14440			0.556	3
UniProt:P05362 ICAM1	1	ICAM1 [plasma membrane] (R-HSA-197683)	0.556	3
UniProt:P58317 ZN121			0.556	3
UniProt:Q9BYX4 IFIH1	3	IFIH1 [cytosol] (R-HSA-913536) K48polyUb-IFIH1 [cytosol] (R-HSA-3080557) PolyUb-IFIH1 [cytosol] (R-HSA-6782812)	0.556	3
UniProt:Q6P6B1 ERICH5	1	ERICH5 [plasma membrane] (R-HSA-9937601)	0.556	3
UniProt:Q9P202 WHRN	1	WHRN [cytosol] (R-HSA-204726)	0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q9UGK3 STAP2	2	p-Y250-STAP2 [plasma membrane] (R-HSA-8848079) STAP2 [cytosol] (R-HSA-8848028)	0.556	3
UniProt:O60336 MABP1			0.556	3
UniProt:Q9NX65 ZSCAN32	1	ZSCAN32 [nucleoplasm] (R-HSA-1247547)	0.556	3
UniProt:Q9P0N9 TBC1D7	1	TBC1D7 [cytosol] (R-HSA-8854154)	0.556	3
UniProt:Q9BWT7 CAR10			0.556	3
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.556	3
UniProt:Q9H1Y0 ATG5	3	ATG5 [phagocytic vesicle membrane] (R-HSA-5205636) GlyK130-ATG5 [cytosol] (R-HSA-5683582) ATG5 [cytosol] (R-HSA-936010)	0.556	3
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.556	3
UniProt:Q8N4I8 Q8N4I8			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:Q4KMZ1 IQCC			0.556	3
UniProt:P38109 ATG42			0.556	3
UniProt:P17709	7	GLK1 [ficolin-1-rich granule lumen] (R-SCE-6801527-3) GLK1 [extracellular region] (R-SCE-6806457-3) GLK1 [secretory granule lumen] (R-SCE-6801511-3) GLK1 [nucleoplasm] (R-SCE-450102-3) GLK1 [cytosol] (R-SCE-70412-3) GLK1 [cytosol] (R-SCE-450094-3) GLK1 [cytosol] (R-SCE-70395-3)	0.556	3
UniProt:Q9BTE3-2 MCMBP			0.556	3
UniProt:Q9NZJ9 NUDT4	1	NUDT4 [cytosol] (R-HSA-1604676)	0.556	3
UniProt:Q8N573-5 OXR1			0.556	3
UniProt:Q9UKX7 NUP50	1	NUP50 [nucleoplasm] (R-HSA-157740)	0.556	3
UniProt:Q8TDV0 GP151			0.556	3
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.556	3
UniProt:Q49AR9 Q49AR9			0.556	3
UniProt:Q15149 PLEC	3	PLEC(2396-4684) [cytosol] (R-HSA-350618) PLEC(1-2395) [cytosol] (R-HSA-350638) PLEC [cytosol] (R-HSA-201575)	0.544	3
UniProt:Q9GZQ8 MAP1LC3B	4	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B [extracellular exosome] (R-HSA-9959986)	0.527	2
UniProt:P33151 CDH5	2	p-S665-VE-cadherin [plasma membrane] (R-HSA-5357435) VE-cadherin [plasma membrane] (R-HSA-418992)	0.527	2
UniProt:Q8IVL6 P3H3	1	LEPREL2 [endoplasmic reticulum lumen] (R-HSA-1650821)	0.527	2
UniProt:Q9BTE3 MCMBP			0.527	2
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.527	2
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.527	2
UniProt:O95407 TNFRSF6B	1	TNFRSF6B [extracellular region] (R-HSA-5675950)	0.527	2
UniProt:Q96HS1 PGAM5			0.527	3
UniProt:Q9Y3R4 NEU2	1	NEU2 [cytosol] (R-HSA-1605759)	0.527	2
UniProt:P54274 TERF1	1	TERF1 [nucleoplasm] (R-HSA-164618)	0.508	2
UniProt:O88351	2	phospho-Ikbkb [cytosol] (R-MMU-202506) Ikbkb [cytosol] (R-MMU-168114)	0.508	2
UniProt:P15314	1	Irf1 [nucleoplasm] (R-MMU-983456)	0.499	2
UniProt:P58004 SESN2	1	SESN2 [cytosol] (R-HSA-5629143)	0.499	3
UniProt:Q5JTC6 AMER1	5	AMER1 [cytosol] (R-HSA-1504189) AMER1 R353* [cytosol] (R-HSA-9663939) AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 R497* [cytosol] (R-HSA-9663943)	0.499	2
UniProt:Q9UF56 FBXL17	1	FBXL17 [nucleoplasm] (R-HSA-9708570)	0.462	7

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