Reactome | ZBTB16 [cytosol]

ZBTB16 [cytosol]

Stable Identifier

R-HSA-976047

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Zinc finger and BTB domain-containing protein 16, ZBT16_HUMAN, PLZF

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
      - Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
      - Polyubiquitination of substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
      - Release of E3 from polyubiquitinated substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
      - Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
18246121	Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation Costoya, JA, Hobbs, RM, Pandolfi, PP	Oncogene	2008
25821988	G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L Zhang, T, Dong, K, Liang, W, Xu, D, Xia, H, Geng, J, Najafov, A, Liu, M, Li, Y, Han, X, Xiao, J, Jin, Z, Peng, T, Gao, Y, Cai, Y, Qi, C, Zhang, Q, Sun, A, Lipinski, M, Zhu, H, Xiong, Y, Pandolfi, PP, Li, H, Yu, Q, Yuan, J	Elife	2015
24990570	Implication of intracellular localization of transcriptional repressor PLZF in thyroid neoplasms Matsuzawa, K, Izawa, S, Ohkura, T, Ohkura, H, Ishiguro, K, Yoshida, A, Takiyama, Y, Haneda, M, Shigemasa, C, Yamamoto, K, Taniguchi, S	BMC Endocr Disord	2014

External Reference Information

External Reference

UniProt:Q05516 ZBTB16

Gene Names

ZBTB16, PLZF, ZNF145

Chain

chain:1-673

Reference Genes

BioGPS Gene:7704 ZBTB16

COSMIC (genes):ZBTB16 ZBTB16

CTD Gene:7704 ZBTB16

dbSNP Gene:7704 ZBTB16

ENSEMBL:ENSG00000109906 ZBTB16

HGNC:12930 ZBTB16

KEGG Gene (Homo sapiens):7704 ZBTB16

Monarch:7704 ZBTB16

NCBI Gene:7704 ZBTB16

OMIM:176797 ZBTB16

UCSC:Q05516 ZBTB16

Reference Transcript

Other Identifiers

0004610048

11729371_a_at

1499

16731441

1BUO

1CS3

205883_at

3349720

3349721

3349722

3349723

3349724

3349731

3349732

3349733

3349734

3349735

3349736

3349767

3349782

3349812

3349819

3349822

3349823

3349824

39681_at

4540

7704

7943984

A0A024R3C6

A_23_P104804

AAC60590

AAD03619

AAH26902

AAH29812

AF060568

ALQ33858

BC026902

BC029812

CAA79489

CAB004540

CCDS8367

CH471065

EAW67241

EAW67242

ENSG00000109906

ENSP00000338157

ENSP00000376721

ENST00000335953

ENST00000335953.8

ENST00000392996

ENST00000392996.2

EntrezGene:7704

EntrezGene:ZBTB16

F5H5Y7

F5H6C3

g5174752_3p_at

GE60361

GO:0000003

GO:0000122

GO:0000980

GO:0000981

GO:0001227

GO:0001501

GO:0001823

GO:0002376

GO:0003674

GO:0003676

GO:0003677

GO:0003690

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0006464

GO:0006915

GO:0007155

GO:0007417

GO:0008022

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0009058

GO:0009790

GO:0009880

GO:0009952

GO:0016567

GO:0016604

GO:0016605

GO:0016607

GO:0017053

GO:0019904

GO:0030097

GO:0030099

GO:0030154

GO:0032332

GO:0032991

GO:0034504

GO:0034641

GO:0035116

GO:0035136

GO:0035137

GO:0042733

GO:0042802

GO:0042803

GO:0043065

GO:0043167

GO:0043226

GO:0043565

GO:0043687

GO:0045600

GO:0045638

GO:0045778

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0048133

GO:0048856

GO:0051138

GO:0051216

GO:0051301

GO:0061036

HGNC:12930

HPA001499

ILMN_1722244

ILMN_1750496

ILMN_2305407

ILMN_2402817

IPR000210

IPR011333

IPR013087

IPR036236

KU178400

MIM:176797

MIM:612447

NM_001018011

NM_001354750

NM_001354751

NM_001354752

NM_006006

NP_001018011

NP_001341679

NP_001341680

NP_001341681

NP_005997

PF00096

PF00651

PF13912

PH_hs_0002937

S60093

SM00225

SM00355

TC11001026.hg

UPI000000018E

XM_017018259

XP_016873748

Z19002

Z19002_at

ZBTB16

ZBTB16-201

ZBTB16-202

Participant Of

hasMember

BTB proteins [cytosol]

Inferred To

ZBTB16 [cytosol] (Caenorhabditis elegans)

ZBTB16 [cytosol] (Danio rerio)

ZBTB16 [cytosol] (Drosophila melanogaster)

ZBTB16 [cytosol] (Rattus norvegicus)

Homologues of ZBTB16 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

XP_016873746.1, NP_005997.2, XP_016873748.1, NP_001018011.1, XP_016873747.1

OpenTargets

ENSG00000109906

GeneCards

Q05516

PRO

Q05516

Orphanet

22649

HMDB Protein

HMDBP10907

PDB

1BUO, 1CS3

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.781	7
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848)	0.721	4
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.666	4
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.621	5
UniProt:P29590 PML	5	SUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) SUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) SUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.611	7
UniProt:P68104 EEF1A1	7	Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.593	4
UniProt:P05231 IL6	3	IL6 [endoplasmic reticulum lumen] (R-HSA-8956764) p-IL6 [endoplasmic reticulum lumen] (R-HSA-8957044) IL6 [extracellular region] (R-HSA-447100)	0.573	2
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.57	3
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.553	2
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.488	2
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.488	2
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.488	2
UniProt:Q8WY64 MYLIP	1	MYLIP [cytosol] (R-HSA-8850908)	0.488	2