Reactome | ZBTB16 [cytosol]

ZBTB16 [cytosol]

Stable Identifier

R-HSA-976047

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Zinc finger and BTB domain-containing protein 16, ZBT16_HUMAN, PLZF

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
      - Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
      - Polyubiquitination of substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
      - Release of E3 from polyubiquitinated substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
      - Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        ZBTB16 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
25821988	G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L Geng, J, Xu, D, Liu, M, Xia, H, Li, H, Yu, Q, Jin, Z, Zhu, H, Gao, Y, Liang, W, Cai, Y, Xiong, Y, Dong, K, Lipinski, M, Han, X, Peng, T, Xiao, J, Najafov, A, Sun, A, Pandolfi, PP, Zhang, Q, Qi, C, Zhang, T, Yuan, J, Li, Y	Elife	2015
18246121	Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation Pandolfi, PP, Costoya, JA, Hobbs, RM	Oncogene	2008
24990570	Implication of intracellular localization of transcriptional repressor PLZF in thyroid neoplasms Taniguchi, S, Ishiguro, K, Ohkura, H, Yoshida, A, Ohkura, T, Takiyama, Y, Matsuzawa, K, Shigemasa, C, Haneda, M, Yamamoto, K, Izawa, S	BMC Endocr Disord	2014

External Reference Information

External Reference

UniProt:Q05516 ZBTB16

Gene Names

ZBTB16, PLZF, ZNF145

Chain

chain:1-673

Reference Genes

BioGPS Gene:7704 ZBTB16

COSMIC (genes):ZBTB16 ZBTB16

CTD Gene:7704 ZBTB16

dbSNP Gene:7704 ZBTB16

ENSEMBL:ENSG00000109906 ZBTB16

HGNC:12930 ZBTB16

KEGG:hsa:7704 ZBTB16

Monarch:7704 ZBTB16

NCBI Gene:7704 ZBTB16

OMIM:176797 ZBTB16

UCSC:Q05516 ZBTB16

Reference Transcript

Other Identifiers

11729371_a_at

16731441

205883_PM_at

205883_at

227762_PM_at

227762_at

228854_PM_at

228854_at

231262_PM_at

231262_at

3349720

3349721

3349722

3349723

3349724

3349725

3349726

3349727

3349728

3349729

3349730

3349731

3349732

3349733

3349734

3349735

3349736

3349738

3349739

3349754

3349765

3349767

3349778

3349779

3349780

3349782

3349783

3349784

3349785

3349806

3349812

3349817

3349818

3349819

3349822

3349823

3349824

3349851

3349853

3349855

3349857

3349859

3349860

3349861

39681_at

59769_s_at

60851_r_at

7704

7943984

83008_at

87998_at

90494_at

A_14_P103711

A_23_P104804

GE60361

GE836627

GE839033

GE84030

GE86649

GO:0000122

GO:0000978

GO:0001222

GO:0001227

GO:0001228

GO:0001501

GO:0001673

GO:0001823

GO:0003677

GO:0003690

GO:0003700

GO:0005515

GO:0005634

GO:0005829

GO:0006355

GO:0006357

GO:0006915

GO:0007417

GO:0008283

GO:0008285

GO:0009880

GO:0009952

GO:0012501

GO:0016567

GO:0016604

GO:0016605

GO:0016607

GO:0017053

GO:0019904

GO:0030097

GO:0030099

GO:0030154

GO:0031703

GO:0032332

GO:0032991

GO:0034504

GO:0035116

GO:0035136

GO:0035137

GO:0042733

GO:0042802

GO:0042803

GO:0043065

GO:0043226

GO:0043931

GO:0045600

GO:0045638

GO:0045778

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0048133

GO:0048856

GO:0051138

GO:0051216

GO:0061036

GO:0140110

HMNXSV003001279

HMNXSV003033124

HMNXSV003056163

Hs.117176.2.A1_3p_at

Hs.147375.0.A1_3p_at

Hs.22971.0.A1_3p_at

ILMN_1750496

ILMN_2305407

ILMN_2402817

PH_hs_0002937

PH_hs_0021782

TC11001026.hg

Z19002_at

g5174752_3p_at

Participates

as a member of

BTB proteins [cytosol] (Homo sapiens)

Inferred To

zfp-2 [cytosol] (Caenorhabditis elegans)

ZBTB16 [cytosol] (Canis familiaris)

ZBTB16 [cytosol] (Drosophila melanogaster)

Dmel\CG17385 [cytosol] (Drosophila melanogaster)

sfc2 [cytosol] (Schizosaccharomyces pombe)

Homologues of ZBTB16 [cytosol] (Caenorhabditis elegans)

Homologues of ZBTB16 [cytosol] (Drosophila melanogaster)

Homologues of ZBTB16 [cytosol] (Schizosaccharomyces pombe)

Zbtb16 [cytosol] (Rattus norvegicus)

prz1 [cytosol] (Schizosaccharomyces pombe)

che-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_016873747.1, XP_016873748.1, NP_001018011.1, NP_005997.2, XP_016873746.1

OpenTargets

ENSG00000109906

ENSEMBL

ENSP00000506953, ENSP00000338157, ENSP00000507788, ENSP00000506794, ENSP00000506894, ENSP00000508351, ENST00000683318, ENSP00000376721, ENST00000335953, ENST00000392996, ENSP00000506924, ENST00000684295, ENST00000682971, ENST00000683554, ENST00000682278, ENST00000682697

HPA

ENSG00000109906-ZBTB16

PRO

Q05516

Pharos - Targets

Q05516

Orphanet

ZBTB16

HMDB Protein

HMDBP10907

PDB

1BUO, 1CS3

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.83	8
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.795	8
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.739	5
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.702	6
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.696	5
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.621	5
UniProt:P29590 PML	5	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.611	7
UniProt:P68104 EEF1A1	7	EEF1A1 [lysosomal membrane] (R-HSA-9626022) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) Me3K79-EEF1A1 [cytosol] (R-HSA-8932212)	0.593	4
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.57	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:Q8WY64 MYLIP	1	MYLIP [cytosol] (R-HSA-8850908)	0.556	3
UniProt:P05231 IL6	3	IL6 [extracellular region] (R-HSA-447100) IL6 [endoplasmic reticulum lumen] (R-HSA-8956764) p-IL6 [endoplasmic reticulum lumen] (R-HSA-8957044)	0.519	2

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