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TRIM37 [cytosol]
Stable Identifier
R-HSA-976049
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase TRIM37, TRI37_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM37 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM37 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM37 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM37 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM37 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM37 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM37 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM37 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM37 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM37 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94972 TRIM37
Gene Names
TRIM37, KIAA0898, MUL, POB1
Chain
chain:1-964
Reference Genes
BioGPS Gene:4591 TRIM37
COSMIC (genes):TRIM37 TRIM37
CTD Gene:4591 TRIM37
dbSNP Gene:4591 TRIM37
ENSEMBL:ENSG00000108395 TRIM37
HGNC:7523 TRIM37
KEGG Gene (Homo sapiens):4591 TRIM37
Monarch:4591 TRIM37
NCBI Gene:4591 TRIM37
OMIM:605073 TRIM37
UCSC:O94972 TRIM37
Reference Transcript
RefSeq:NM_015294.4 TRIM37
RefSeq:NM_001320990.1 TRIM37
RefSeq:NM_001320987.1 TRIM37
RefSeq:NM_001005207.3 TRIM37
Other Identifiers
0003870164
11721084_a_at
11721085_a_at
11730164_a_at
11748457_a_at
1554001_at
16847209
213009_s_at
33107_at
3764681
3764690
3764691
3764693
3764696
3764697
3764698
3764702
3764703
3764704
3764705
3764707
3764708
3764709
3764710
3764711
3764712
3764714
3764716
3764718
3764719
3764720
3764722
3764724
3764726
3764728
3764731
3764732
3764733
4591
8017106
A_23_P21230
A_24_P153853
GE53570
GO:0000122
GO:0003674
GO:0003682
GO:0004842
GO:0005164
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005777
GO:0005829
GO:0006464
GO:0007010
GO:0007049
GO:0008150
GO:0008270
GO:0009058
GO:0016235
GO:0016567
GO:0016740
GO:0019899
GO:0022607
GO:0031625
GO:0032088
GO:0032991
GO:0034641
GO:0035098
GO:0035518
GO:0036353
GO:0042803
GO:0043167
GO:0043226
GO:0046600
GO:0046872
GO:0048471
GO:0051091
GO:0051092
GO:0051276
GO:0051865
GO:0061630
GO:0070842
Hs.8164.0.S1_3p_a_at
Hs2.8164.2.S1_3p_at
ILMN_1671513
ILMN_1687703
ILMN_1704383
ILMN_1711327
PH_hs_0040431
TC17001743.hg
Participant Of
hasCandidate
E3 ligases in proteasomal degradation [cytosol]
Inferred To
TRIM37 [cytosol] (Canis familiaris)
TRIM37 [cytosol] (Gallus gallus)
TRIM37 [cytosol] (Sus scrofa)
Trim37 [cytosol] (Mus musculus)
Trim37 [cytosol] (Rattus norvegicus)
trim37 [cytosol] (Danio rerio)
trim37 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_001307916.1
,
NP_056109.1
,
NP_001005207.1
,
NP_001307919.1
Target Pathogen
5b354852be737e166372ee0a
OpenTargets
ENSG00000108395
GeneCards
O94972
HPA
ENSG00000108395-TRIM37
Ensembl
ENST00000393066
,
ENST00000393065
,
ENSP00000376784
,
ENST00000262294
,
ENSP00000376785
,
ENSP00000262294
,
ENSG00000108395
PRO
O94972
Orphanet
15663
PDB
3LRQ
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13895 BYSL
2
BYSL [cytosol]
(R-HSA-6791518)
BYSL [nucleoplasm]
(R-HSA-6791526)
0.781
9
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.666
4
UniProt:O43663 PRC1
1
PRC1 [cytosol]
(R-HSA-264441)
0.635
3
UniProt:O15169 AXIN1
11
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
AXIN1 [cytosol]
(R-HSA-195249)
p-T519,S524,S531-AXIN1 [cytosol]
(R-HSA-206040)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:P39009
2
phospho-DUN1 [nucleoplasm]
(R-SCE-113825)
phospho-DUN1 [nucleoplasm]
(R-SCE-5683784)
0.556
3
UniProt:O00311 CDC7
1
CDC7 [nucleoplasm]
(R-HSA-51781)
0.556
3
UniProt:Q7L590 MCM10
1
MCM10 [nucleoplasm]
(R-HSA-68403)
0.553
2
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