Reactome | TRIM37 [cytosol]

TRIM37 [cytosol]

Stable Identifier

R-HSA-976049

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase TRIM37, TRI37_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O94972 TRIM37

Gene Names

TRIM37, KIAA0898, MUL, POB1

Chain

chain:1-964

Reference Genes

BioGPS Gene:4591 TRIM37

COSMIC (genes):TRIM37 TRIM37

CTD Gene:4591 TRIM37

dbSNP Gene:4591 TRIM37

ENSEMBL:ENSG00000108395 TRIM37

HGNC:7523 TRIM37

KEGG Gene (Homo sapiens):4591 TRIM37

Monarch:4591 TRIM37

NCBI Gene:4591 TRIM37

OMIM:605073 TRIM37

UCSC:O94972 TRIM37

Reference Transcript

Other Identifiers

0003870164

11721084_a_at

11721085_a_at

11730164_a_at

11748457_a_at

1554001_at

16847209

213009_s_at

33107_at

3764681

3764690

3764691

3764693

3764696

3764697

3764698

3764702

3764703

3764704

3764705

3764707

3764708

3764709

3764710

3764711

3764712

3764714

3764716

3764718

3764719

3764720

3764722

3764724

3764726

3764728

3764731

3764732

3764733

4591

8017106

A_23_P21230

A_24_P153853

GE53570

GO:0000122

GO:0003674

GO:0003682

GO:0004842

GO:0005164

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005777

GO:0005829

GO:0006464

GO:0007010

GO:0007049

GO:0008150

GO:0008270

GO:0009058

GO:0016235

GO:0016567

GO:0016740

GO:0019899

GO:0022607

GO:0031625

GO:0032088

GO:0032991

GO:0034641

GO:0035098

GO:0035518

GO:0036353

GO:0042803

GO:0043167

GO:0043226

GO:0046600

GO:0046872

GO:0048471

GO:0051091

GO:0051092

GO:0051276

GO:0051865

GO:0061630

GO:0070842

Hs.8164.0.S1_3p_a_at

Hs2.8164.2.S1_3p_at

ILMN_1671513

ILMN_1687703

ILMN_1704383

ILMN_1711327

PH_hs_0040431

TC17001743.hg

Participant Of

hasCandidate

E3 ligases in proteasomal degradation [cytosol]

Inferred To

TRIM37 [cytosol] (Canis familiaris)

TRIM37 [cytosol] (Gallus gallus)

TRIM37 [cytosol] (Sus scrofa)

Trim37 [cytosol] (Mus musculus)

Trim37 [cytosol] (Rattus norvegicus)

trim37 [cytosol] (Danio rerio)

trim37 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001307916.1, NP_056109.1, NP_001005207.1, NP_001307919.1

Target Pathogen

5b354852be737e166372ee0a

OpenTargets

ENSG00000108395

GeneCards

O94972

HPA

ENSG00000108395-TRIM37

Ensembl

ENST00000393066, ENST00000393065, ENSP00000376784, ENST00000262294, ENSP00000376785, ENSP00000262294, ENSG00000108395

PRO

O94972

Orphanet

15663

PDB

3LRQ

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13895 BYSL	2	BYSL [cytosol] (R-HSA-6791518) BYSL [nucleoplasm] (R-HSA-6791526)	0.781	9
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.666	4
UniProt:O43663 PRC1	1	PRC1 [cytosol] (R-HSA-264441)	0.635	3
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P39009	2	phospho-DUN1 [nucleoplasm] (R-SCE-113825) phospho-DUN1 [nucleoplasm] (R-SCE-5683784)	0.556	3
UniProt:O00311 CDC7	1	CDC7 [nucleoplasm] (R-HSA-51781)	0.556	3
UniProt:Q7L590 MCM10	1	MCM10 [nucleoplasm] (R-HSA-68403)	0.553	2