Reactome | UHRF2 [nucleoplasm]

UHRF2 [nucleoplasm]

Stable Identifier

R-HSA-976050

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase UHRF2, UHRF2_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of transcription cofactors (Homo sapiens)
        
        CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Homo sapiens)
        
        CBX4, UHRF2 [nucleoplasm] (Homo sapiens)
        
        UHRF2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96PU4 UHRF2

Gene Names

UHRF2, NIRF, RNF107

Chain

chain:1-802

Reference Genes

BioGPS Gene:115426 UHRF2

COSMIC (genes):UHRF2 UHRF2

CTD Gene:115426 UHRF2

dbSNP Gene:115426 UHRF2

ENSEMBL:ENSG00000147854 UHRF2

ENSEMBL_homo_sapiens_GENE:ENSG00000147854.17 UHRF2

HGNC:12557 UHRF2

KEGG Gene (Homo sapiens):115426 UHRF2

Monarch:115426 UHRF2

NCBI Gene:115426 UHRF2

OMIM:615211 UHRF2

UCSC:Q96PU4 UHRF2

Reference Transcript

RefSeq:NM_152896.2 UHRF2

Other Identifiers

115426

11718186_a_at

17083452

225610_PM_at

225610_at

3161399

3161400

3161401

3161402

3161406

3161409

3161419

3161423

3161424

3161425

3161426

3161427

3161429

3161431

3161432

3161436

3161437

3161439

3161441

3161442

3161445

3161447

3161448

3981838

3981861

53732_at

8154316

A_23_P9144

A_24_P303815

A_33_P3279715

GE482538

GO:0000792

GO:0003677

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005721

GO:0007049

GO:0016567

GO:0016740

GO:0016925

GO:0019789

GO:0030154

GO:0036211

GO:0042393

GO:0043226

GO:0046872

GO:0051726

GO:0051865

GO:0061629

GO:0061630

GO:0140096

HMNXSV003033558

HMNXSV003050641

Hs.12258.0.S1_3p_at

ILMN_1691444

PH_hs_0024552

PH_hs_0033103

TC09000047.hg

Participates

as a member of

CBX4, UHRF2 [nucleoplasm] (Homo sapiens)

Inferred To

Uhrf2 [nucleoplasm] (Mus musculus)

Uhrf2 [nucleoplasm] (Rattus norvegicus)

UHRF2 [nucleoplasm] (Bos taurus)

UHRF2 [nucleoplasm] (Gallus gallus)

uhrf2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_690856.1

OpenTargets

ENSG00000147854

HPA

ENSG00000147854-UHRF2

GeneCards

Q96PU4

Ensembl

ENSG00000147854, ENSP00000434182, ENSP00000276893, ENST00000276893, ENST00000468435

PRO

Q96PU4

Pharos - Targets

Q96PU4

PDB

5YCO, 1Z6U, 4PW7, 3OLN, 2E6S, 4TVR, 1WY8, 4PW5, 4PW6

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.729	5
UniProt:P24864 CCNE1	3	CCNE1 [nucleoplasm] (R-HSA-68363) CCNE1 [cytosol] (R-HSA-157443) Unfolded CCNE1 [cytosol] (R-HSA-6813836)	0.602	4
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) p-T286-CCND1 [cytosol] (R-HSA-75813)	0.602	4
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.591	4
UniProt:P09429 HMGB1	5	HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291) HMGB1 [extracellular region] (R-HSA-879382) HMGB1 [nucleoplasm] (R-HSA-266221) HC23,45-HMGB1 [extracellular region] (R-HSA-6797422)	0.553	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.524	3

Cite Us!