Reactome | ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]

ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]

Stable Identifier

R-HSA-9762058

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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External Reference Information

External Reference

UniProt:Q16236 NFE2L2

Gene Names

NFE2L2, NRF2

Chain

chain:1-605

Reference Genes

BioGPS Gene:4780 NFE2L2

COSMIC (genes):NFE2L2 NFE2L2

CTD Gene:4780 NFE2L2

dbSNP Gene:4780 NFE2L2

ENSEMBL:ENSG00000116044 NFE2L2

ENSEMBL_homo_sapiens_GENE:ENSG00000116044.17 NFE2L2

HGNC:7782 NFE2L2

KEGG Gene (Homo sapiens):4780 NFE2L2

Monarch:4780 NFE2L2

NCBI Gene:4780 NFE2L2

OMIM:600492 NFE2L2

UCSC:Q16236 NFE2L2

Reference Transcript

Other Identifiers

11739057_a_at

11743380_s_at

1567013_PM_at

1567013_at

16905475

201146_PM_at

201146_at

2588833

2588834

2588835

2588836

2588837

2588838

2588839

2588841

2588843

2588844

2588845

2588846

2588847

2588863

2588864

2588865

2588866

2588867

2588868

2588896

2588909

2588910

2588913

2588915

2588916

2588924

4780

8056977

853_at

A_23_P5761

A_33_P3225600

GE81603

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001221

GO:0001228

GO:0002376

GO:0002931

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006351

GO:0006355

GO:0006357

GO:0006575

GO:0006790

GO:0006954

GO:0006979

GO:0009410

GO:0010033

GO:0010468

GO:0010499

GO:0010628

GO:0010667

GO:0010976

GO:0012501

GO:0016567

GO:0019904

GO:0023052

GO:0030154

GO:0030163

GO:0030194

GO:0030968

GO:0031625

GO:0032993

GO:0034599

GO:0034976

GO:0036211

GO:0036499

GO:0042060

GO:0042149

GO:0043161

GO:0043226

GO:0043536

GO:0043565

GO:0045088

GO:0045454

GO:0045766

GO:0045893

GO:0045944

GO:0045995

GO:0046223

GO:0046326

GO:0048856

GO:0048870

GO:0051171

GO:0055085

GO:0061629

GO:0070301

GO:0071280

GO:0071356

GO:0071456

GO:0071466

GO:0071498

GO:0071499

GO:0080090

GO:0090575

GO:0098542

GO:0098754

GO:0140110

GO:0140467

GO:1900038

GO:1900407

GO:1902037

GO:1902176

GO:1903788

GO:1904294

GO:1904385

GO:1904753

GO:2000060

GO:2000121

GO:2000352

GO:2000379

HMNXSV003047979

ILMN_1790909

PH_hs_0009358

S74017_at

TC02004721.hg

TC02005045.hg

g5453775_3p_at

Participates

as a candidate of

ub,p-S335, 338 NFE2L2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-S,T,S558-NFE2L2 [nucleoplasm]

p-S40, S344, S347- NFE2L2 [nucleoplasm]

p-S344, S347,T-NFE2L2 [nucleoplasm]

ub-p-S335, S338,T-NFE2L2 [nucleoplasm]

ub-NFE2L2 [cytosol]

p-S40-18 AcK-NFE2L2 [nucleoplasm]

p-S,T-18 AcK-NFE2L2 [nucleoplasm]

NFE2L2 [cytosol]

p-S,T-NFE2L2 [cytosol]

p-S40-NFE2L2 [cytosol]

p-S,T-NFE2L2 [nucleoplasm]

p-S40-NFE2L2 [nucleoplasm]

Inferred To

phospho-skn-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-nfe2l2 [nucleoplasm] (Xenopus tropicalis)

phospho-NFE2L2 [nucleoplasm] (Bos taurus)

phospho-NFE2L2 [nucleoplasm] (Canis familiaris)

phospho-NFE2L2 [nucleoplasm] (Sus scrofa)

phospho-Nfe2l2 [nucleoplasm] (Mus musculus)

phospho-Nfe2l2 [nucleoplasm] (Rattus norvegicus)

Homologues of ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (Caenorhabditis elegans)

phospho-cnc [nucleoplasm] (Drosophila melanogaster)

phospho-ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (Gallus gallus)

phospho-nfe2l2a [nucleoplasm] (Danio rerio)

phospho-sknr-1 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 40

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 344

Coordinate

344

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 347

Coordinate

347

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine (K48polyUb [nucleoplasm]) at unknown position

Modification

K48polyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001138885.1, NP_001300829.1, NP_006155.2, NP_001138884.1, NP_001300830.1

Guide to Pharmacology - Targets

3057

OpenTargets

ENSG00000116044

ZINC - Substances

NF2L2_HUMAN

ZINC - Biogenic

NF2L2_HUMAN

ZINC target

Q16236

PRO

Q16236

PDB

7K2B, 7X5F, 7X5G, 7O7B, 7K2K, 2LZ1, 7K28, 3ZGC, 7K29, 7K2C, 7K2D, 5WFV, 4IFL, 8EJR, 7X5E, 8EJS, 7K2E, 6T7V, 7K2A, 2FLU

HPA

ENSG00000116044-NFE2L2

GeneCards

Q16236

Ensembl

ENST00000699351, ENST00000699330, ENSP00000412191, ENST00000699408, ENST00000699409, ENSP00000380253, ENSP00000380252, ENST00000421929, ENST00000397063, ENSP00000514386, ENSP00000400073, ENSP00000514369, ENST00000699328, ENST00000699343, ENST00000397062, ENST00000446151, ENSP00000514318, ENSP00000411575, ENST00000464747, ENSP00000514304, ENSP00000514303, ENSP00000514325, ENSP00000467401, ENSG00000116044, ENSP00000514370, ENST00000448782, ENST00000699434

Pharos - Targets

Q16236

ZINC - Predictions - Purchasable

NF2L2_HUMAN

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.978	39
UniProt:O15525 MAFG	1	MAFG [nucleoplasm] (R-HSA-1008212)	0.939	16
UniProt:O60675 MAFK	1	MAFK [nucleoplasm] (R-HSA-1008242)	0.806	7
UniProt:Q9ULX9 MAFF	1	MAFF [nucleoplasm] (R-HSA-1008261)	0.77	6
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.727	8
IntAct:EBI-4399559 UBIQ			0.667	3
UniProt:P13805 TNNT1	1	TNNT1 [cytosol] (R-HSA-390544)	0.666	4
UniProt:O60519 CRBL2			0.625	5
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.625	5
UniProt:O15144 ARPC2	1	ARPC2 [cytosol] (R-HSA-200809)	0.625	5
UniProt:Q10587 TEF			0.625	5
UniProt:P41212 ETV6	14	p-12Y-ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673912) p-11Y-ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673905) ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673893) ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673898) ETV6(1-384)-FLT3(569-993) fusion [cytosol] (R-HSA-9697944) ETV6(1-301)-FLT3(574-993) fusion [cytosol] (R-HSA-9703315) ETV6(1-384)-FLT3(573-993) fusion [cytosol] (R-HSA-9703307) ETV6(1-336)insGCS-FLT3(573-993) fusion [cytosol] (R-HSA-9703320) ETV6(1-154)insGSFILG-FLT3(573-993) fusion [cytosol] (R-HSA-9703312) ETV6(1-384)-p-3Y-FLT3(659-1620) fusion [cytosol] (R-HSA-9703313) ETV6(1-301)-p-6Y-FLT3(574-993) fusion [cytosol] (R-HSA-9703318) ETV6(1-336)insGCS-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703305) ETV6(1-154)insGSFILG-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703302) ETV6(1-384)-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703308)	0.625	5
UniProt:O75822 EIF3J	1	EIF3J [cytosol] (R-HSA-72534)	0.625	5
UniProt:Q9NS37 ZHANG			0.625	5
UniProt:P53567 CEBPG	1	CEBPG [nucleoplasm] (R-HSA-9644320)	0.625	5
UniProt:P15408 FOSL2			0.625	6
UniProt:P53539 FOSB	1	FOSB [nucleoplasm] (R-HSA-9009922)	0.625	6
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.625	5
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.625	5
UniProt:P20226 TBP	1	TBP [nucleoplasm] (R-HSA-83718)	0.625	5
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.625	5
UniProt:P52564 MAP2K6	3	MAP2K6 [cytosol] (R-HSA-167998) p-S207,T211-MAP2K6 [cytosol] (R-HSA-206255) p-S207,T211-MAP2K6 [nucleoplasm] (R-HSA-450258)	0.625	5
UniProt:P43268 ETV4	1	ETV4 [nucleoplasm] (R-HSA-5687030)	0.625	6
UniProt:P18847 ATF3	1	ATF3 [nucleoplasm] (R-HSA-535543)	0.625	5
UniProt:P41227 NAA10			0.602	4
UniProt:Q13342 SP140			0.581	4
UniProt:O94916 NFAT5			0.581	4
UniProt:P50549 ETV1			0.581	4
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.581	4
UniProt:P78545 ELF3	2	ELF3 [nucleoplasm] (R-HSA-9021353) p-S68-ELF3 [nucleoplasm] (R-HSA-9021349)	0.581	5
UniProt:Q9BTA9 WAC	1	WAC [nucleoplasm] (R-HSA-8942150)	0.556	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.556	5
UniProt:P13805-3 TNNT1			0.556	3
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.547	2
UniProt:Q60953	4	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-MMU-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-MMU-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-MMU-3000440) PML [nucleoplasm] (R-MMU-1031706)	0.544	2
UniProt:P11416 Rara	3	phospho-SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-MMU-5334830) Rara [nucleoplasm] (R-MMU-5618000) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-MMU-4341042)	0.544	2
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.524	2
UniProt:Q9ULD4 BRPF3	3	BRPF3 [extracellular region] (R-HSA-350700) BRPF3 [cytosol] (R-HSA-350716) BRPF3 [nucleoplasm] (R-HSA-3318471)	0.508	3
UniProt:Q96G23 CERS2	1	CERS2 [endoplasmic reticulum membrane] (R-HSA-428171)	0.508	2
UniProt:P55210 CASP7	5	CASP7(24-198) [nucleoplasm] (R-HSA-351927) CASP7(207-303) [nucleoplasm] (R-HSA-351924) CASP7(2-303) [cytosol] (R-HSA-57029) CASP7(24-198) [cytosol] (R-HSA-141641) CASP7(207-303) [cytosol] (R-HSA-141642)	0.508	2
UniProt:P15976 GATA1	1	GATA1 [nucleoplasm] (R-HSA-996772)	0.508	2
UniProt:Q6V702 CF299			0.508	3
UniProt:Q9UJU2 LEF1	2	LEF1 [nucleoplasm] (R-HSA-3214972) pT155,S166-LEF1 [nucleoplasm] (R-HSA-4411389)	0.508	3
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.508	4
UniProt:P10914 IRF1	2	IRF1 [nucleoplasm] (R-HSA-983456) IRF1 [cytosol] (R-HSA-1015686)	0.508	3
UniProt:P27695 APEX1	1	APEX1 [nucleoplasm] (R-HSA-50119)	0.508	3
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.508	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.508	2
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.508	2
UniProt:P15036 ETS2	2	p-T72-ETS2 [nucleoplasm] (R-HSA-3132735) ETS2 [nucleoplasm] (R-HSA-1629811)	0.508	2
UniProt:P19419 ELK1	2	ELK1 [nucleoplasm] (R-HSA-3009346) p-4S,T336-ELK1 [nucleoplasm] (R-HSA-3009350)	0.508	5
UniProt:Q77UU1 Q77UU1			0.488	2
UniProt:O95718-3 ESRRB			0.463	2

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