MYC binds the NFE2L2 promoter

Stable Identifier
R-HSA-9762097
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MYC binds the NFE2L2 promoter
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MYC binds to its cognate binding site in the promoter of the NFE2L2 gene to drive its expression in head and neck cancers (Tang et al, 2021). NFE2L2 upregulation downstream of MYC stimulates transcription of NFE2L2 target genes in the pentose phosphate pathway such as glucose-6-phosphate dehydrogenase (G6PD) and transaldolase (TALDO1) and contributes to metabolic reprogramming and oncogenic progression (Tang et al, 2021; reviewed in He et al, 2020; Kitamura et al, 2020).
Literature References
PubMed ID Title Journal Year
29450944 NRF2 addiction in cancer cells

Motohashi, H, Kitamura, H

Cancer Sci 2018
33859744 c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation

Chu, PY, Chen, HH, Lin, LM, Chang, JY, Lin, SF, Chen, YT, Liu, KJ, Huang, YW, Chuang, YJ, Kuo, CC, Tsai, FY, Fang, HL, Hsiao, JR, Jiang, SS, Tang, YC

Theranostics 2021
32640524 NRF2, a Transcription Factor for Stress Response and Beyond

He, F, Wen, T, Ru, X

Int J Mol Sci 2020
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Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2022-01-17)
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